IT1318687B1 - Multi-layer controlled-release tablet comprises an active layer and at least one barrier layer, useful for the treatment of e.g. Parkinson's disease - Google Patents
Multi-layer controlled-release tablet comprises an active layer and at least one barrier layer, useful for the treatment of e.g. Parkinson's diseaseInfo
- Publication number
- IT1318687B1 IT1318687B1 IT2000MI001963A ITMI20001963A IT1318687B1 IT 1318687 B1 IT1318687 B1 IT 1318687B1 IT 2000MI001963 A IT2000MI001963 A IT 2000MI001963A IT MI20001963 A ITMI20001963 A IT MI20001963A IT 1318687 B1 IT1318687 B1 IT 1318687B1
- Authority
- IT
- Italy
- Prior art keywords
- layer
- release tablet
- parkinson
- tablet comprises
- disease
- Prior art date
Links
- 230000004888 barrier function Effects 0.000 title abstract 2
- 238000013270 controlled release Methods 0.000 title abstract 2
- 208000018737 Parkinson disease Diseases 0.000 title 1
- 239000000126 substance Substances 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 230000006835 compression Effects 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
Abstract
A multi-layer controlled-release tablet comprises: (A) an active layer containing (a) an active substance; (b) hydrophilic polymeric substance which swell and/or gel and/or erode upon contact with aqueous liquids; (c) lipophilic substance; and (d) adjuvant substance; and (B) at least one barrier layer containing at least one of (b), (c) and (d). A weight ratio of (b) to (c) in (A) is 10:1 - 0.5:1. An Independent claim is included for the preparation of the tablet involving compression of the powder or granular mixture and working between 1000 - 5000 kg/cm2.
Priority Applications (39)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2000MI001963A IT1318687B1 (en) | 2000-09-07 | 2000-09-07 | Multi-layer controlled-release tablet comprises an active layer and at least one barrier layer, useful for the treatment of e.g. Parkinson's disease |
ARP010101750A AR030557A1 (en) | 2000-04-14 | 2001-04-11 | A TABLET IN MULTI-MAP OF CONTROLLED RELEASE AND TREATMENT METHOD |
MXPA02010151A MXPA02010151A (en) | 2000-04-14 | 2001-04-12 | Hydrophilic lipophilic polymeric matrix dosage formulation. |
DE60134964T DE60134964D1 (en) | 2000-04-14 | 2001-04-12 | Ropinirole-containing dosage form with a hydrophilic / lipophilic matrix |
PL365837A PL202689B1 (en) | 2000-04-14 | 2001-04-12 | Hydrophilic/lipophilic polymeric matrix dosage formulation |
ES01921605T ES2307608T3 (en) | 2000-04-14 | 2001-04-12 | DOSAGE FORMULATION CONTAINING ROPINIROL IN A HYDROPHYL / LIPOFILA POLYMERIC MATRIX. |
KR1020097017509A KR101158968B1 (en) | 2000-04-14 | 2001-04-12 | Hydrophilic/lipophilic polymeric matrix dosage formulation |
ES06075502.2T ES2580043T3 (en) | 2000-04-14 | 2001-04-12 | Multilayer controlled release tablet comprising an active layer and one or more barrier layers |
CNB018091164A CN1198598C (en) | 2000-04-14 | 2001-04-12 | Hydrophilic/lipophilic polymeric matrix dosage for mulation |
PT01921605T PT1272167E (en) | 2000-04-14 | 2001-04-12 | Ropinirole-containing hydrophilic/liphilic polymeric matrix dosage formulation |
KR1020087011476A KR20080047630A (en) | 2000-04-14 | 2001-04-12 | Hydrophilic/lipophilic polymeric matrix dosage formulation |
AU48576/01A AU779623B2 (en) | 2000-04-14 | 2001-04-12 | Hydrophilic/lipophilic polymeric matrix dosage formulation |
CA2405508A CA2405508C (en) | 2000-04-14 | 2001-04-12 | Hydrophilic/lipophilic polymeric matrix dosage formulation |
PCT/GB2001/001726 WO2001078688A1 (en) | 2000-04-14 | 2001-04-12 | Hydrophilic/lipophilic polymeric matrix dosage formulation |
KR1020077013182A KR20070065922A (en) | 2000-04-14 | 2001-04-12 | Hydrophilic/lipophilic polymeric matrix dosage formulation |
DK01921605T DK1272167T3 (en) | 2000-04-14 | 2001-04-12 | Ropinirole-containing hydrophilic / lipophilic polymer matrix dosing formulation |
HU0300530A HU228269B1 (en) | 2000-04-14 | 2001-04-12 | Hydrophilic/lipophilic polymeric matrix dosage formulation |
IL15218401A IL152184A0 (en) | 2000-04-14 | 2001-04-12 | Hydrophilic/lipophilic polymeric matrix dosage formulation |
US10/257,709 US20030180359A1 (en) | 2000-04-14 | 2001-04-12 | Hydrophilic/ lipophilic polymeric matrix dosage formulation |
EP06075502.2A EP1681051B1 (en) | 2000-04-14 | 2001-04-12 | Multi-layer controlled-release tablet comprising an active layer and one or more barrier layers |
AT01921605T ATE401867T1 (en) | 2000-04-14 | 2001-04-12 | DOSAGE FORM CONTAINING ROPINIROL WITH A HYDROPHILIC/LIPOPHILIC MATRIX |
SI200130871T SI1272167T1 (en) | 2000-04-14 | 2001-04-12 | Ropinirole-containing hydrophilic/liphilic polymeric matrix dosage formulation |
EP01921605A EP1272167B1 (en) | 2000-04-14 | 2001-04-12 | Ropinirole-containing hydrophilic/liphilic polymeric matrix dosage formulation |
NZ521902A NZ521902A (en) | 2000-04-14 | 2001-04-12 | Hydrophilic/lipophilic polymeric matrix dosage formulation |
BRPI0110038A BRPI0110038C1 (en) | 2000-04-14 | 2001-04-12 | multilayer controlled release tablet containing ropinirole, and use of ropinirole |
EP10176790A EP2343060A1 (en) | 2000-04-14 | 2001-04-12 | Multi-layer controlled-release tablet comprising an active layer and one or more barrier layers |
KR1020027013768A KR100823392B1 (en) | 2000-04-14 | 2001-04-12 | Hydrophilic/lipophilic polymeric matrix dosage formulation |
JP2001575989A JP5073907B2 (en) | 2000-04-14 | 2001-04-12 | Hydrophilic / lipophilic polymeric matrix dosage formulation |
CZ20023415A CZ303943B6 (en) | 2000-04-14 | 2001-04-12 | Multi-layer tablet with controlled release of active substance |
EP16192165.5A EP3175848A1 (en) | 2000-04-14 | 2001-04-12 | Multi-layer controlled-release tablet comprising an active layer and one or more barrier layers |
IL152184A IL152184A (en) | 2000-04-14 | 2002-10-08 | Multi-layer hydrophilic/lipophilic release tablet |
NO20024919A NO333572B1 (en) | 2000-04-14 | 2002-10-11 | Ropinirole-containing hydrophilic / lipophilic polymer matrix dosage formulation |
HK03104356A HK1053602A1 (en) | 2000-04-14 | 2003-06-17 | Ropinirole-containing hydrophilic/liphilic polymeric matrix dosage formulation |
AU2005201805A AU2005201805B2 (en) | 2000-04-14 | 2005-04-29 | Hydrophilic / lipophilic polymeric matrix dosage formulation |
US11/717,502 US7927624B2 (en) | 2000-04-14 | 2007-03-12 | Hydrophilic/lipophilic polymeric matrix dosage formulation |
JP2008199847A JP5420207B2 (en) | 2000-04-14 | 2008-08-01 | Hydrophilic / lipophilic polymeric matrix dosage formulation |
US12/478,946 US8303986B2 (en) | 2000-04-14 | 2009-06-05 | Hydrophilic/lipophilic polymeric matrix dosage formulation |
AU2009230759A AU2009230759A1 (en) | 2000-04-14 | 2009-10-26 | Hydrophilic / lipophilic polymeric matrix dosage formulation |
US13/022,281 US8460706B2 (en) | 2000-04-14 | 2011-02-07 | Hydrophilic/lipophilic polymeric matrix dosage formulation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2000MI001963A IT1318687B1 (en) | 2000-09-07 | 2000-09-07 | Multi-layer controlled-release tablet comprises an active layer and at least one barrier layer, useful for the treatment of e.g. Parkinson's disease |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI20001963A0 ITMI20001963A0 (en) | 2000-09-07 |
ITMI20001963A1 ITMI20001963A1 (en) | 2002-03-07 |
IT1318687B1 true IT1318687B1 (en) | 2003-08-27 |
Family
ID=11445764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT2000MI001963A IT1318687B1 (en) | 2000-04-14 | 2000-09-07 | Multi-layer controlled-release tablet comprises an active layer and at least one barrier layer, useful for the treatment of e.g. Parkinson's disease |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1318687B1 (en) |
-
2000
- 2000-09-07 IT IT2000MI001963A patent/IT1318687B1/en active
Also Published As
Publication number | Publication date |
---|---|
ITMI20001963A1 (en) | 2002-03-07 |
ITMI20001963A0 (en) | 2000-09-07 |
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