IT1313607B1 - New non-human transgenic animal, being transgenic for an antibody e.g. anti-nerve growth factor antibody, useful for the study of neurodegenerative, muscular and/or immune disorders - Google Patents

New non-human transgenic animal, being transgenic for an antibody e.g. anti-nerve growth factor antibody, useful for the study of neurodegenerative, muscular and/or immune disorders

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Publication number
IT1313607B1
IT1313607B1 ITMI991783A IT1313607B1 IT 1313607 B1 IT1313607 B1 IT 1313607B1 IT MI991783 A ITMI991783 A IT MI991783A IT 1313607 B1 IT1313607 B1 IT 1313607B1
Authority
IT
Italy
Prior art keywords
antibody
transgenic
muscular
neurodegenerative
study
Prior art date
Application number
Other languages
Italian (it)
Inventor
Antonino Cattaneo
Simona Capsoni
Francesca Ruberti
Original Assignee
S I S S A Scuola Internaz Supe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S I S S A Scuola Internaz Supe filed Critical S I S S A Scuola Internaz Supe
Publication of ITMI991783A0 publication Critical patent/ITMI991783A0/en
Priority to IT1999MI001783 priority Critical patent/IT1313607B1/en
Priority to CA002388341A priority patent/CA2388341A1/en
Priority to EP00951857A priority patent/EP1255824B1/en
Priority to JP2001514752A priority patent/JP2003518922A/en
Priority to US10/049,306 priority patent/US7273964B1/en
Priority to PCT/IT2000/000321 priority patent/WO2001010203A2/en
Priority to AU64700/00A priority patent/AU783964B2/en
Priority to AT00951857T priority patent/ATE463567T1/en
Priority to DK00951857.2T priority patent/DK1255824T3/en
Priority to DE60044149T priority patent/DE60044149D1/en
Publication of ITMI991783A1 publication Critical patent/ITMI991783A1/en
Application granted granted Critical
Publication of IT1313607B1 publication Critical patent/IT1313607B1/en

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Non-human transgenic animal (I), being transgenic for an antibody (II) or its fragments and with a phenotype reminiscent of a human pathology, is new. Independent claims are also included for the following: (1) cells (III) derivable from (I) and secreting (II); and (2) preparation of (I) comprising: (a) preparing a first non-human transgenic parent animal for the light chain of an antibody and a second non-human transgenic parent animal for the heavy chain of the same antibody; (b) breeding the 2 transgenic parent animals; and (c) selecting the progeny expressing both the light and the heavy chain; ACTIVITY : Muscular active. No supporting data is given. MECHANISM OF ACTION : None given.
IT1999MI001783 1999-08-06 1999-08-06 New non-human transgenic animal, being transgenic for an antibody e.g. anti-nerve growth factor antibody, useful for the study of neurodegenerative, muscular and/or immune disorders IT1313607B1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT1999MI001783 IT1313607B1 (en) 1999-08-06 1999-08-06 New non-human transgenic animal, being transgenic for an antibody e.g. anti-nerve growth factor antibody, useful for the study of neurodegenerative, muscular and/or immune disorders
US10/049,306 US7273964B1 (en) 1999-08-06 2000-07-28 Non-human transgenic animals for the study of neurodegenerative syndromes
EP00951857A EP1255824B1 (en) 1999-08-06 2000-07-28 Transgenic mice for the study of neurodegenerative syndromes
JP2001514752A JP2003518922A (en) 1999-08-06 2000-07-28 Non-human transgenic animals for studying neurodegenerative syndrome
CA002388341A CA2388341A1 (en) 1999-08-06 2000-07-28 Non-human transgenic animals for the study of neurodegenerative syndromes
PCT/IT2000/000321 WO2001010203A2 (en) 1999-08-06 2000-07-28 Non-human transgenic animals for the study of neurodegenerative syndromes
AU64700/00A AU783964B2 (en) 1999-08-06 2000-07-28 Non-human transgenic animals for the study of neurodegenerative syndromes
AT00951857T ATE463567T1 (en) 1999-08-06 2000-07-28 TRANSGENIC MICE FOR STUDYING NEURODEGENERATIVE SYNDROME
DK00951857.2T DK1255824T3 (en) 1999-08-06 2000-07-28 Transgenic mice for the study of neurodegenerative syndromes
DE60044149T DE60044149D1 (en) 1999-08-06 2000-07-28 TRANSGENIC MICE FOR STUDYING NEURODEEGENERATIVE SYNDROMES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI001783 IT1313607B1 (en) 1999-08-06 1999-08-06 New non-human transgenic animal, being transgenic for an antibody e.g. anti-nerve growth factor antibody, useful for the study of neurodegenerative, muscular and/or immune disorders

Publications (3)

Publication Number Publication Date
ITMI991783A0 ITMI991783A0 (en) 1999-08-06
ITMI991783A1 ITMI991783A1 (en) 2001-02-06
IT1313607B1 true IT1313607B1 (en) 2002-09-09

Family

ID=11383528

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1999MI001783 IT1313607B1 (en) 1999-08-06 1999-08-06 New non-human transgenic animal, being transgenic for an antibody e.g. anti-nerve growth factor antibody, useful for the study of neurodegenerative, muscular and/or immune disorders

Country Status (1)

Country Link
IT (1) IT1313607B1 (en)

Also Published As

Publication number Publication date
ITMI991783A0 (en) 1999-08-06
ITMI991783A1 (en) 2001-02-06

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