IT1313607B1 - New non-human transgenic animal, being transgenic for an antibody e.g. anti-nerve growth factor antibody, useful for the study of neurodegenerative, muscular and/or immune disorders - Google Patents
New non-human transgenic animal, being transgenic for an antibody e.g. anti-nerve growth factor antibody, useful for the study of neurodegenerative, muscular and/or immune disordersInfo
- Publication number
- IT1313607B1 IT1313607B1 ITMI991783A IT1313607B1 IT 1313607 B1 IT1313607 B1 IT 1313607B1 IT MI991783 A ITMI991783 A IT MI991783A IT 1313607 B1 IT1313607 B1 IT 1313607B1
- Authority
- IT
- Italy
- Prior art keywords
- antibody
- transgenic
- muscular
- neurodegenerative
- study
- Prior art date
Links
- 230000009261 transgenic effect Effects 0.000 title abstract 7
- 241001465754 Metazoa Species 0.000 title abstract 5
- 230000003387 muscular Effects 0.000 title abstract 2
- 208000021642 Muscular disease Diseases 0.000 title 1
- 208000026278 immune system disease Diseases 0.000 title 1
- 229940053128 nerve growth factor Drugs 0.000 title 1
- 208000015122 neurodegenerative disease Diseases 0.000 title 1
- 230000000626 neurodegenerative effect Effects 0.000 title 1
- 238000009395 breeding Methods 0.000 abstract 1
- 230000001488 breeding effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Non-human transgenic animal (I), being transgenic for an antibody (II) or its fragments and with a phenotype reminiscent of a human pathology, is new. Independent claims are also included for the following: (1) cells (III) derivable from (I) and secreting (II); and (2) preparation of (I) comprising: (a) preparing a first non-human transgenic parent animal for the light chain of an antibody and a second non-human transgenic parent animal for the heavy chain of the same antibody; (b) breeding the 2 transgenic parent animals; and (c) selecting the progeny expressing both the light and the heavy chain; ACTIVITY : Muscular active. No supporting data is given. MECHANISM OF ACTION : None given.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI001783 IT1313607B1 (en) | 1999-08-06 | 1999-08-06 | New non-human transgenic animal, being transgenic for an antibody e.g. anti-nerve growth factor antibody, useful for the study of neurodegenerative, muscular and/or immune disorders |
US10/049,306 US7273964B1 (en) | 1999-08-06 | 2000-07-28 | Non-human transgenic animals for the study of neurodegenerative syndromes |
EP00951857A EP1255824B1 (en) | 1999-08-06 | 2000-07-28 | Transgenic mice for the study of neurodegenerative syndromes |
JP2001514752A JP2003518922A (en) | 1999-08-06 | 2000-07-28 | Non-human transgenic animals for studying neurodegenerative syndrome |
CA002388341A CA2388341A1 (en) | 1999-08-06 | 2000-07-28 | Non-human transgenic animals for the study of neurodegenerative syndromes |
PCT/IT2000/000321 WO2001010203A2 (en) | 1999-08-06 | 2000-07-28 | Non-human transgenic animals for the study of neurodegenerative syndromes |
AU64700/00A AU783964B2 (en) | 1999-08-06 | 2000-07-28 | Non-human transgenic animals for the study of neurodegenerative syndromes |
AT00951857T ATE463567T1 (en) | 1999-08-06 | 2000-07-28 | TRANSGENIC MICE FOR STUDYING NEURODEGENERATIVE SYNDROME |
DK00951857.2T DK1255824T3 (en) | 1999-08-06 | 2000-07-28 | Transgenic mice for the study of neurodegenerative syndromes |
DE60044149T DE60044149D1 (en) | 1999-08-06 | 2000-07-28 | TRANSGENIC MICE FOR STUDYING NEURODEEGENERATIVE SYNDROMES |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI001783 IT1313607B1 (en) | 1999-08-06 | 1999-08-06 | New non-human transgenic animal, being transgenic for an antibody e.g. anti-nerve growth factor antibody, useful for the study of neurodegenerative, muscular and/or immune disorders |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI991783A0 ITMI991783A0 (en) | 1999-08-06 |
ITMI991783A1 ITMI991783A1 (en) | 2001-02-06 |
IT1313607B1 true IT1313607B1 (en) | 2002-09-09 |
Family
ID=11383528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT1999MI001783 IT1313607B1 (en) | 1999-08-06 | 1999-08-06 | New non-human transgenic animal, being transgenic for an antibody e.g. anti-nerve growth factor antibody, useful for the study of neurodegenerative, muscular and/or immune disorders |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1313607B1 (en) |
-
1999
- 1999-08-06 IT IT1999MI001783 patent/IT1313607B1/en active
Also Published As
Publication number | Publication date |
---|---|
ITMI991783A0 (en) | 1999-08-06 |
ITMI991783A1 (en) | 2001-02-06 |
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