IT1307330B1 - New quinoline-4-carboxamide derivatives - are neurokinin-2 and -3 receptor antagonists which are useful for treating e.g. respiratory diseases, inflammatory diseases, allergies etc. - Google Patents

New quinoline-4-carboxamide derivatives - are neurokinin-2 and -3 receptor antagonists which are useful for treating e.g. respiratory diseases, inflammatory diseases, allergies etc.

Info

Publication number
IT1307330B1
IT1307330B1 ITMI961688A IT1307330B1 IT 1307330 B1 IT1307330 B1 IT 1307330B1 IT MI961688 A ITMI961688 A IT MI961688A IT 1307330 B1 IT1307330 B1 IT 1307330B1
Authority
IT
Italy
Prior art keywords
neurokinin
treating
useful
carboxamide derivatives
receptor antagonists
Prior art date
Application number
Other languages
Italian (it)
Inventor
Giuseppe Arnaldo Mari Giardina
Luca Francesco Raveglia
Mario Grugni
Carlo Farina
Original Assignee
Smithkline Beecham Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Publication of ITMI961688A0 publication Critical patent/ITMI961688A0/it
Priority to IT96MI001688 priority Critical patent/IT1307330B1/en
Priority to ARP960105282A priority patent/AR004735A1/en
Priority to NZ323388A priority patent/NZ323388A/en
Priority to EA199800538A priority patent/EA001771B1/en
Priority to TR1998/00883T priority patent/TR199800883T2/en
Priority to KR1019980703874A priority patent/KR19990071598A/en
Priority to PCT/EP1996/005207 priority patent/WO1997019926A1/en
Priority to PL96326928A priority patent/PL326928A1/en
Priority to EP96941025A priority patent/EP1019377A1/en
Priority to HU9901016A priority patent/HUP9901016A3/en
Priority to IL12441896A priority patent/IL124418A0/en
Priority to SK668-98A priority patent/SK66898A3/en
Priority to UY24375A priority patent/UY24375A1/en
Priority to CA002238328A priority patent/CA2238328A1/en
Priority to JP09520158A priority patent/JP2000513325A/en
Priority to CN96199747A priority patent/CN1207729A/en
Priority to MA24399A priority patent/MA24011A1/en
Priority to AU10318/97A priority patent/AU1031897A/en
Priority to APAP/P/1998/001238A priority patent/AP9801238A0/en
Priority to BR9611757A priority patent/BR9611757A/en
Priority to CZ981580A priority patent/CZ158098A3/en
Priority to TW085114501A priority patent/TW409123B/en
Priority to DZ960173A priority patent/DZ2128A1/en
Priority to IDP963513A priority patent/ID16747A/en
Priority to PE00084096A priority patent/PE23098A1/en
Priority to UY24555A priority patent/UY24555A1/en
Publication of ITMI961688A1 publication Critical patent/ITMI961688A1/en
Priority to OA9800062A priority patent/OA11011A/en
Priority to MX9804108A priority patent/MX9804108A/en
Priority to NO19982333A priority patent/NO311213B1/en
Priority to BG102557A priority patent/BG102557A/en
Application granted granted Critical
Publication of IT1307330B1 publication Critical patent/IT1307330B1/en
Priority to US09/994,402 priority patent/US20020068827A1/en

Links

Abstract

Quinoline-4-carboxamide derivatives of formula (I), their salts and solvates, are new. In (I), Ar = e.g. optionally substituted aryl, 5-7C cycloalkdienyl; R = 1-6C alkyl; 3-7C cycloalkyl; 3-7C cycloalkylalkyl; optionally substituted phenyl etc.; R1 = e.g. H, 1-6C alkyl, 1-6C alkenyl, aryl, 1-6C alkoxy, OH, halo, NO2, CN, carboxy etc.; n = 1-4; R2 = e.g. H, 1-6C alkyl, OH, halo, CN, NH2, mono- or di-alkylamino, alkylsulphonylamino etc.; R3 = e.g. 1-6C alkyl, 3-7C cycloalkyl, 4-7C cycloalkylalkyl etc.; and R4 = H or 1-6C alkyl.
IT96MI001688 1995-11-24 1996-08-02 New quinoline-4-carboxamide derivatives - are neurokinin-2 and -3 receptor antagonists which are useful for treating e.g. respiratory diseases, inflammatory diseases, allergies etc. IT1307330B1 (en)

Priority Applications (31)

Application Number Priority Date Filing Date Title
IT96MI001688 IT1307330B1 (en) 1996-08-02 1996-08-02 New quinoline-4-carboxamide derivatives - are neurokinin-2 and -3 receptor antagonists which are useful for treating e.g. respiratory diseases, inflammatory diseases, allergies etc.
ARP960105282A AR004735A1 (en) 1995-11-24 1996-11-21 CHINOLEIN 4-AMIDO SUBSTITUTED, A PROCEDURE FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND THE USE OF THE SAME FOR THE PREPARATION OF A MEDICINAL PRODUCT.
MA24399A MA24011A1 (en) 1995-11-24 1996-11-22 PROCESS FOR THE PREPARATION OF NEW COMPOUNDS
AU10318/97A AU1031897A (en) 1995-11-24 1996-11-22 Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (nk-3)- and neurokinin 2 (nk-2) receptor antagonists.
TR1998/00883T TR199800883T2 (en) 1995-11-24 1996-11-22 Quinoline-4-Carboxamide derivatives, their preparation, and their use as neurokinin 3 (NK-3)- and neurokinin 2 (NK-2) receptor antagonists.
KR1019980703874A KR19990071598A (en) 1995-11-24 1996-11-22 Quinoline-4-carboxamide derivative, its preparation method and its use as neurokinin 3 (NK-3) and neurokinin 2 (NK-2) receptor antagonist
PCT/EP1996/005207 WO1997019926A1 (en) 1995-11-24 1996-11-22 Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (nk-3)- and neurokinin 2 (nk-2) receptor antagonists.
PL96326928A PL326928A1 (en) 1995-11-24 1996-11-22 Quinolin-4-carboxyamidic derivatives, their production and their application as antagonists ofneurokinin-3 (nk-3) and neurokinin-2 (nk-2)
EP96941025A EP1019377A1 (en) 1995-11-24 1996-11-22 Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (nk-3)- and neurokinin 2 (nk-2) receptor antagonists.
HU9901016A HUP9901016A3 (en) 1995-11-24 1996-11-22 Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3(nk-3)-and neurokinin 2(nk-2) receptor antagonists
IL12441896A IL124418A0 (en) 1995-11-24 1996-11-22 Quinoline-4-carboxamide derivatives their preparation and their use as neurokinin 3 (NK-3)- and neurokinin 2 (NK-2) receptor antagonists
SK668-98A SK66898A3 (en) 1995-11-24 1996-11-22 Quinoline-4-carboxamide derivatives, their preparation and their use
UY24375A UY24375A1 (en) 1995-11-24 1996-11-22 PROCEDURE FOR THE PREPARATION OF QUINOLIN-4-CARBOXAMIDE DERIVATIVES
CA002238328A CA2238328A1 (en) 1995-11-24 1996-11-22 Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (nk-3)- and neurokinin 2 (nk-2) receptor antagonists.
JP09520158A JP2000513325A (en) 1995-11-24 1996-11-22 Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (NK-3) and neurokinin 2 (NK-2) receptor antagonists
CN96199747A CN1207729A (en) 1995-11-24 1996-11-22 Quinoline-4-carboxamide derivs., their preparation and their use as neurokinin 3 (NK-3)- and neurokinin 2 (NK-2) receptor antagonists
NZ323388A NZ323388A (en) 1995-11-24 1996-11-22 Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (NK-3) and neurokinin 2 (NK-2) receptor antagonists
EA199800538A EA001771B1 (en) 1995-11-24 1996-11-22 Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin-3 (-k-3) and neurokinin-2 (-k-2) receptor antagonists
APAP/P/1998/001238A AP9801238A0 (en) 1995-11-24 1996-11-22 Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (NK-3)- and neurokinin 2 (NK-2) receptor antagonists.
BR9611757A BR9611757A (en) 1995-11-24 1996-11-22 Quinoline-4-carboxamide derivatives their preparation and use as neurokinin 3 (nk-3) -and neuroquinin 2 (nk-2) receptor antagonites
CZ981580A CZ158098A3 (en) 1995-11-24 1996-11-22 Quiinoline-4-carboxamide derivatives, process of their preparation pharmaceutical preparation and their use as antagonists of neurokinin 3(nk-3) and 2(nk-2) receptors
TW085114501A TW409123B (en) 1995-11-24 1996-11-23 Quinoline derivatives and pharmaceutical composition containing the same
DZ960173A DZ2128A1 (en) 1995-11-24 1996-11-23 New compounds, process for their preparation and pharmaceutical compositions containing them.
IDP963513A ID16747A (en) 1996-08-02 1996-11-29 QUINOLINA'S DEMONS
PE00084096A PE23098A1 (en) 1996-08-02 1996-12-03 NEW QUINOLINE-4-CARBOXAMIDE DERIVATIVES
UY24555A UY24555A1 (en) 1995-11-24 1997-05-16 NEW COMPOUNDS
NO19982333A NO311213B1 (en) 1995-11-24 1998-05-22 Quinoline carboxamide derivatives, their preparation and their use as Neurokinin 3 (NK-3) and Neurokinin 2 (NK-2) receptor antagonists, as well as pharmaceutical preparations containing them
OA9800062A OA11011A (en) 1995-11-24 1998-05-22 Quinoline-4-carboxamide derivatives their preparation and their use as neurokin 3 (nk-3)-and neurokin 2 (nk-2)receptor antagonists
MX9804108A MX9804108A (en) 1995-11-24 1998-05-22 Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (nk-3)- and neurokinin 2 (nk-2) receptor antagonists.
BG102557A BG102557A (en) 1995-11-24 1998-06-18 Derivatives of quinoline-4-carboxamides, method for their preparation and application as neurokinin 3(nk-3) and neurokinin 2(nk-2) receptor antagonists
US09/994,402 US20020068827A1 (en) 1995-11-24 2001-11-26 Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 ( NK-3 ) - and neurokinin 2 ( NK-3 ) receptor antagonists

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI001688 IT1307330B1 (en) 1996-08-02 1996-08-02 New quinoline-4-carboxamide derivatives - are neurokinin-2 and -3 receptor antagonists which are useful for treating e.g. respiratory diseases, inflammatory diseases, allergies etc.

Publications (3)

Publication Number Publication Date
ITMI961688A0 ITMI961688A0 (en) 1996-08-02
ITMI961688A1 ITMI961688A1 (en) 1998-02-02
IT1307330B1 true IT1307330B1 (en) 2001-10-30

Family

ID=11374758

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96MI001688 IT1307330B1 (en) 1995-11-24 1996-08-02 New quinoline-4-carboxamide derivatives - are neurokinin-2 and -3 receptor antagonists which are useful for treating e.g. respiratory diseases, inflammatory diseases, allergies etc.

Country Status (3)

Country Link
ID (1) ID16747A (en)
IT (1) IT1307330B1 (en)
PE (1) PE23098A1 (en)

Also Published As

Publication number Publication date
ITMI961688A0 (en) 1996-08-02
ITMI961688A1 (en) 1998-02-02
ID16747A (en) 1997-11-06
PE23098A1 (en) 1998-05-08

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