IT1307330B1 - New quinoline-4-carboxamide derivatives - are neurokinin-2 and -3 receptor antagonists which are useful for treating e.g. respiratory diseases, inflammatory diseases, allergies etc. - Google Patents
New quinoline-4-carboxamide derivatives - are neurokinin-2 and -3 receptor antagonists which are useful for treating e.g. respiratory diseases, inflammatory diseases, allergies etc.Info
- Publication number
- IT1307330B1 IT1307330B1 ITMI961688A IT1307330B1 IT 1307330 B1 IT1307330 B1 IT 1307330B1 IT MI961688 A ITMI961688 A IT MI961688A IT 1307330 B1 IT1307330 B1 IT 1307330B1
- Authority
- IT
- Italy
- Prior art keywords
- neurokinin
- treating
- useful
- carboxamide derivatives
- receptor antagonists
- Prior art date
Links
- LEWDKQKVAFOMPI-UHFFFAOYSA-N quinoline-4-carboxamide Chemical class C1=CC=C2C(C(=O)N)=CC=NC2=C1 LEWDKQKVAFOMPI-UHFFFAOYSA-N 0.000 title abstract 2
- 101000831616 Homo sapiens Protachykinin-1 Proteins 0.000 title 1
- 206010020751 Hypersensitivity Diseases 0.000 title 1
- 102000002003 Neurokinin-3 Receptors Human genes 0.000 title 1
- 108010040716 Neurokinin-3 Receptors Proteins 0.000 title 1
- 102100024304 Protachykinin-1 Human genes 0.000 title 1
- 230000007815 allergy Effects 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 208000023504 respiratory system disease Diseases 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Abstract
Quinoline-4-carboxamide derivatives of formula (I), their salts and solvates, are new. In (I), Ar = e.g. optionally substituted aryl, 5-7C cycloalkdienyl; R = 1-6C alkyl; 3-7C cycloalkyl; 3-7C cycloalkylalkyl; optionally substituted phenyl etc.; R1 = e.g. H, 1-6C alkyl, 1-6C alkenyl, aryl, 1-6C alkoxy, OH, halo, NO2, CN, carboxy etc.; n = 1-4; R2 = e.g. H, 1-6C alkyl, OH, halo, CN, NH2, mono- or di-alkylamino, alkylsulphonylamino etc.; R3 = e.g. 1-6C alkyl, 3-7C cycloalkyl, 4-7C cycloalkylalkyl etc.; and R4 = H or 1-6C alkyl.
Priority Applications (31)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI001688 IT1307330B1 (en) | 1996-08-02 | 1996-08-02 | New quinoline-4-carboxamide derivatives - are neurokinin-2 and -3 receptor antagonists which are useful for treating e.g. respiratory diseases, inflammatory diseases, allergies etc. |
ARP960105282A AR004735A1 (en) | 1995-11-24 | 1996-11-21 | CHINOLEIN 4-AMIDO SUBSTITUTED, A PROCEDURE FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND THE USE OF THE SAME FOR THE PREPARATION OF A MEDICINAL PRODUCT. |
MA24399A MA24011A1 (en) | 1995-11-24 | 1996-11-22 | PROCESS FOR THE PREPARATION OF NEW COMPOUNDS |
AU10318/97A AU1031897A (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (nk-3)- and neurokinin 2 (nk-2) receptor antagonists. |
TR1998/00883T TR199800883T2 (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-Carboxamide derivatives, their preparation, and their use as neurokinin 3 (NK-3)- and neurokinin 2 (NK-2) receptor antagonists. |
KR1019980703874A KR19990071598A (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivative, its preparation method and its use as neurokinin 3 (NK-3) and neurokinin 2 (NK-2) receptor antagonist |
PCT/EP1996/005207 WO1997019926A1 (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (nk-3)- and neurokinin 2 (nk-2) receptor antagonists. |
PL96326928A PL326928A1 (en) | 1995-11-24 | 1996-11-22 | Quinolin-4-carboxyamidic derivatives, their production and their application as antagonists ofneurokinin-3 (nk-3) and neurokinin-2 (nk-2) |
EP96941025A EP1019377A1 (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (nk-3)- and neurokinin 2 (nk-2) receptor antagonists. |
HU9901016A HUP9901016A3 (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3(nk-3)-and neurokinin 2(nk-2) receptor antagonists |
IL12441896A IL124418A0 (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives their preparation and their use as neurokinin 3 (NK-3)- and neurokinin 2 (NK-2) receptor antagonists |
SK668-98A SK66898A3 (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives, their preparation and their use |
UY24375A UY24375A1 (en) | 1995-11-24 | 1996-11-22 | PROCEDURE FOR THE PREPARATION OF QUINOLIN-4-CARBOXAMIDE DERIVATIVES |
CA002238328A CA2238328A1 (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (nk-3)- and neurokinin 2 (nk-2) receptor antagonists. |
JP09520158A JP2000513325A (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (NK-3) and neurokinin 2 (NK-2) receptor antagonists |
CN96199747A CN1207729A (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivs., their preparation and their use as neurokinin 3 (NK-3)- and neurokinin 2 (NK-2) receptor antagonists |
NZ323388A NZ323388A (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (NK-3) and neurokinin 2 (NK-2) receptor antagonists |
EA199800538A EA001771B1 (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin-3 (-k-3) and neurokinin-2 (-k-2) receptor antagonists |
APAP/P/1998/001238A AP9801238A0 (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (NK-3)- and neurokinin 2 (NK-2) receptor antagonists. |
BR9611757A BR9611757A (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives their preparation and use as neurokinin 3 (nk-3) -and neuroquinin 2 (nk-2) receptor antagonites |
CZ981580A CZ158098A3 (en) | 1995-11-24 | 1996-11-22 | Quiinoline-4-carboxamide derivatives, process of their preparation pharmaceutical preparation and their use as antagonists of neurokinin 3(nk-3) and 2(nk-2) receptors |
TW085114501A TW409123B (en) | 1995-11-24 | 1996-11-23 | Quinoline derivatives and pharmaceutical composition containing the same |
DZ960173A DZ2128A1 (en) | 1995-11-24 | 1996-11-23 | New compounds, process for their preparation and pharmaceutical compositions containing them. |
IDP963513A ID16747A (en) | 1996-08-02 | 1996-11-29 | QUINOLINA'S DEMONS |
PE00084096A PE23098A1 (en) | 1996-08-02 | 1996-12-03 | NEW QUINOLINE-4-CARBOXAMIDE DERIVATIVES |
UY24555A UY24555A1 (en) | 1995-11-24 | 1997-05-16 | NEW COMPOUNDS |
NO19982333A NO311213B1 (en) | 1995-11-24 | 1998-05-22 | Quinoline carboxamide derivatives, their preparation and their use as Neurokinin 3 (NK-3) and Neurokinin 2 (NK-2) receptor antagonists, as well as pharmaceutical preparations containing them |
OA9800062A OA11011A (en) | 1995-11-24 | 1998-05-22 | Quinoline-4-carboxamide derivatives their preparation and their use as neurokin 3 (nk-3)-and neurokin 2 (nk-2)receptor antagonists |
MX9804108A MX9804108A (en) | 1995-11-24 | 1998-05-22 | Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (nk-3)- and neurokinin 2 (nk-2) receptor antagonists. |
BG102557A BG102557A (en) | 1995-11-24 | 1998-06-18 | Derivatives of quinoline-4-carboxamides, method for their preparation and application as neurokinin 3(nk-3) and neurokinin 2(nk-2) receptor antagonists |
US09/994,402 US20020068827A1 (en) | 1995-11-24 | 2001-11-26 | Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 ( NK-3 ) - and neurokinin 2 ( NK-3 ) receptor antagonists |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI001688 IT1307330B1 (en) | 1996-08-02 | 1996-08-02 | New quinoline-4-carboxamide derivatives - are neurokinin-2 and -3 receptor antagonists which are useful for treating e.g. respiratory diseases, inflammatory diseases, allergies etc. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI961688A0 ITMI961688A0 (en) | 1996-08-02 |
ITMI961688A1 ITMI961688A1 (en) | 1998-02-02 |
IT1307330B1 true IT1307330B1 (en) | 2001-10-30 |
Family
ID=11374758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT96MI001688 IT1307330B1 (en) | 1995-11-24 | 1996-08-02 | New quinoline-4-carboxamide derivatives - are neurokinin-2 and -3 receptor antagonists which are useful for treating e.g. respiratory diseases, inflammatory diseases, allergies etc. |
Country Status (3)
Country | Link |
---|---|
ID (1) | ID16747A (en) |
IT (1) | IT1307330B1 (en) |
PE (1) | PE23098A1 (en) |
-
1996
- 1996-08-02 IT IT96MI001688 patent/IT1307330B1/en active
- 1996-11-29 ID IDP963513A patent/ID16747A/en unknown
- 1996-12-03 PE PE00084096A patent/PE23098A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ITMI961688A0 (en) | 1996-08-02 |
ITMI961688A1 (en) | 1998-02-02 |
ID16747A (en) | 1997-11-06 |
PE23098A1 (en) | 1998-05-08 |
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