IT1307328B1 - New indole derivs. for treating and preventing osteoporosis - also have antitumour, antiulcer and antiviral activity, useful in treating e.g. auto-immune diseases, lipidaemia and atherosclerosis - Google Patents
New indole derivs. for treating and preventing osteoporosis - also have antitumour, antiulcer and antiviral activity, useful in treating e.g. auto-immune diseases, lipidaemia and atherosclerosisInfo
- Publication number
- IT1307328B1 IT1307328B1 ITMI951687A IT1307328B1 IT 1307328 B1 IT1307328 B1 IT 1307328B1 IT MI951687 A ITMI951687 A IT MI951687A IT 1307328 B1 IT1307328 B1 IT 1307328B1
- Authority
- IT
- Italy
- Prior art keywords
- treating
- substd
- opt
- alkyl
- lipidaemia
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title abstract 4
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title abstract 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 208000001132 Osteoporosis Diseases 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 230000000767 anti-ulcer Effects 0.000 title 1
- 230000000840 anti-viral effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- -1 carbalkoxy Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Indole derivs. of formula (I), their salts and solvates are new. either: (i) Ra = R5 and Rb = a gp. of formula -C(R4)=C(R3)-C(R2)=C(OR1)[C(O)X] (a); or (ii) Ra = gp. (a) and Rb = R5; R5 = H, alkyl or opt. substd. aryl; X = OH or opt. substd. alkoxy or NRsRt; R1 = alkyl or opt. substd. aryl gp., R2-R4 = H, alkyl or opt. substd. aryl, Rs, Rt = H or alkyl, alkenyl, aryl, aralkyl, heterocyclyl or heterocyclylalkyl (all opt. substd.); or Rs+Rt = a heterocycle; R6, R7 = H, OH, NH2, alkoxy, opt. substd. aryloxy or benzoyloxy, alkylamino, dialkylamino, halo, CF3, OCF3, NO2, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl; or R6+R7 = methylenedioxy, carbonyldioxy or carbonyldiamino; and R8 = H, OH, alkanoyl, alkyl, aminoalkyl, hydroxyalkyl, carboxyalkyl, carbalkoxyalkyl, carbamoyl or aminosulphonyl.
Priority Applications (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI951687 IT1307328B1 (en) | 1995-08-01 | 1995-08-01 | New indole derivs. for treating and preventing osteoporosis - also have antitumour, antiulcer and antiviral activity, useful in treating e.g. auto-immune diseases, lipidaemia and atherosclerosis |
| APAP/P/1997/001029A AP648A (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis. |
| SK932-97A SK93297A3 (en) | 1995-01-10 | 1996-01-08 | Indole derivatives, method for their producing, pharmaceutical comosition containing the same, and their use |
| CZ972176A CZ217697A3 (en) | 1995-01-10 | 1996-01-08 | Indole derivatives, which can be used for treating osteoporosis, process of their preparation, pharmaceutical composition containing such derivatives and use |
| EP96901275A EP0802902A1 (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis |
| PL96321263A PL321263A1 (en) | 1995-01-10 | 1996-01-08 | Derivatives of indole useful in treating osteoporosis |
| BR9606743A BR9606743A (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis |
| KR1019970704719A KR19980701330A (en) | 1995-01-10 | 1996-01-08 | Indole Derivatives Useful in the Treatment of Osteoporosis (Indole Derivatives Useful in the Treatment of Osteoporosis) |
| AU45360/96A AU4536096A (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis |
| TR97/00625T TR199700625T1 (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis (bone loss). |
| HU9901096A HUP9901096A3 (en) | 1995-01-10 | 1996-01-08 | Indole derivatives, preparation and use thereof, pharmaceutical composition containing these compounds |
| PCT/EP1996/000157 WO1996021644A1 (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis |
| CA002209936A CA2209936A1 (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis |
| JP8521450A JPH10512251A (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful for treating osteoporosis |
| US08/860,760 US5981525A (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis |
| BG101769A BG101769A (en) | 1995-01-10 | 1997-07-07 | Indole derivatives useful in the treatment of osteoporosis |
| OA70046A OA10611A (en) | 1995-01-10 | 1997-07-09 | Indole derivatives useful in the treatment of osteoporosis |
| FI972919A FI972919A (en) | 1995-01-10 | 1997-07-09 | Indole derivatives useful in the treatment of osteoporosis |
| NO973178A NO973178L (en) | 1995-01-10 | 1997-07-09 | Indole derivatives useful in the treatment of osteoporosis |
| MXPA/A/1997/005243A MXPA97005243A (en) | 1995-01-10 | 1997-07-10 | Derivatives of indol and compositions of the same useful in the treatment of osteoporo |
| EA199700098A EA199700098A1 (en) | 1995-01-10 | 1997-08-08 | INDOL DERIVATIVES SUITABLE FOR THE TREATMENT OF OSTEOPOROSIS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI951687 IT1307328B1 (en) | 1995-08-01 | 1995-08-01 | New indole derivs. for treating and preventing osteoporosis - also have antitumour, antiulcer and antiviral activity, useful in treating e.g. auto-immune diseases, lipidaemia and atherosclerosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI951687A0 ITMI951687A0 (en) | 1995-08-01 |
| ITMI951687A1 ITMI951687A1 (en) | 1997-02-01 |
| IT1307328B1 true IT1307328B1 (en) | 2001-10-30 |
Family
ID=11372106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI951687 IT1307328B1 (en) | 1995-01-10 | 1995-08-01 | New indole derivs. for treating and preventing osteoporosis - also have antitumour, antiulcer and antiviral activity, useful in treating e.g. auto-immune diseases, lipidaemia and atherosclerosis |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1307328B1 (en) |
-
1995
- 1995-08-01 IT ITMI951687 patent/IT1307328B1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI951687A1 (en) | 1997-02-01 |
| ITMI951687A0 (en) | 1995-08-01 |
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