IT1303684B1 - FORMULATIONS OF APOMORPHINE IN SOLUTION STABLE OVER TIME. - Google Patents

FORMULATIONS OF APOMORPHINE IN SOLUTION STABLE OVER TIME.

Info

Publication number
IT1303684B1
IT1303684B1 IT1998MI002331A ITMI982331A IT1303684B1 IT 1303684 B1 IT1303684 B1 IT 1303684B1 IT 1998MI002331 A IT1998MI002331 A IT 1998MI002331A IT MI982331 A ITMI982331 A IT MI982331A IT 1303684 B1 IT1303684 B1 IT 1303684B1
Authority
IT
Italy
Prior art keywords
apomorphine
formulations
over time
stable over
solution stable
Prior art date
Application number
IT1998MI002331A
Other languages
Italian (it)
Inventor
Eva Bernini
Gaetano Brambilla
Paolo Chiesi
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Priority to IT1998MI002331A priority Critical patent/IT1303684B1/en
Priority to GR990100373A priority patent/GR990100373A/en
Priority to GB9925602A priority patent/GB2343376B/en
Priority to FR9913521A priority patent/FR2785188B1/en
Priority to ES009902380A priority patent/ES2156763B1/en
Priority to BR9905305-5A priority patent/BR9905305A/en
Publication of ITMI982331A1 publication Critical patent/ITMI982331A1/en
Application granted granted Critical
Publication of IT1303684B1 publication Critical patent/IT1303684B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
IT1998MI002331A 1998-10-30 1998-10-30 FORMULATIONS OF APOMORPHINE IN SOLUTION STABLE OVER TIME. IT1303684B1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT1998MI002331A IT1303684B1 (en) 1998-10-30 1998-10-30 FORMULATIONS OF APOMORPHINE IN SOLUTION STABLE OVER TIME.
GR990100373A GR990100373A (en) 1998-10-30 1999-10-27 Stable apomorphine solution formulations
GB9925602A GB2343376B (en) 1998-10-30 1999-10-28 Stable apomorphine solution formulations
FR9913521A FR2785188B1 (en) 1998-10-30 1999-10-28 STABLE FORMULATIONS OF APOMORPHIN SOLUTION
ES009902380A ES2156763B1 (en) 1998-10-30 1999-10-28 STABLE APOMORPHIN SOLUTION FORMULATIONS.
BR9905305-5A BR9905305A (en) 1998-10-30 1999-10-29 Stable formulations in apomorphine solution

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998MI002331A IT1303684B1 (en) 1998-10-30 1998-10-30 FORMULATIONS OF APOMORPHINE IN SOLUTION STABLE OVER TIME.

Publications (2)

Publication Number Publication Date
ITMI982331A1 ITMI982331A1 (en) 2000-04-30
IT1303684B1 true IT1303684B1 (en) 2001-02-23

Family

ID=11380970

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1998MI002331A IT1303684B1 (en) 1998-10-30 1998-10-30 FORMULATIONS OF APOMORPHINE IN SOLUTION STABLE OVER TIME.

Country Status (6)

Country Link
BR (1) BR9905305A (en)
ES (1) ES2156763B1 (en)
FR (1) FR2785188B1 (en)
GB (1) GB2343376B (en)
GR (1) GR990100373A (en)
IT (1) IT1303684B1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02003312A (en) * 1999-09-29 2002-10-04 Procter & Gamble Compositions having improved stability.
TW200526268A (en) * 2003-12-17 2005-08-16 Takeda Pharmaceutical Injectable composition
TW201035054A (en) * 2009-02-27 2010-10-01 Lundbeck & Co As H Methods of administering (4aR, 10aR)-1-n-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol and pharmaceutical compositions thereof
CA2875446A1 (en) 2012-06-05 2013-12-12 Neuroderm Ltd. Compositions comprising apomorphine and organic acids and uses thereof
WO2015157212A1 (en) * 2014-04-10 2015-10-15 Us Worldmeds, Llc Stable apomorphine composition and uses thereof

Also Published As

Publication number Publication date
FR2785188A1 (en) 2000-05-05
BR9905305A (en) 2001-03-20
GB2343376A (en) 2000-05-10
ES2156763B1 (en) 2002-03-01
FR2785188B1 (en) 2004-10-29
ITMI982331A1 (en) 2000-04-30
GB2343376B (en) 2003-12-31
GR990100373A (en) 2000-06-30
GB9925602D0 (en) 1999-12-29
ES2156763A1 (en) 2001-07-01

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