IT1296976B1 - New quinoline arylmethylcarboxamide are NK-2 and NK-3 receptor antagonists - useful for treating asthma, arthritis, dermatitis, organ transplant, anxiety, depression, angina, pain, Alzheimer's disease - Google Patents

New quinoline arylmethylcarboxamide are NK-2 and NK-3 receptor antagonists - useful for treating asthma, arthritis, dermatitis, organ transplant, anxiety, depression, angina, pain, Alzheimer's disease

Info

Publication number
IT1296976B1
IT1296976B1 ITMI972775A IT1296976B1 IT 1296976 B1 IT1296976 B1 IT 1296976B1 IT MI972775 A ITMI972775 A IT MI972775A IT 1296976 B1 IT1296976 B1 IT 1296976B1
Authority
IT
Italy
Prior art keywords
alkyl
mono
arylmethylcarboxamide
angina
dermatitis
Prior art date
Application number
Other languages
Italian (it)
Inventor
Giuseppe Arnaldo Mari Giardina
Davide Graziani
Mario Grugni
Luca Francesco Raveglia
Original Assignee
Smithkline Beecham Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ITMI972775 priority Critical patent/IT1296976B1/en
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Priority to PL98336942A priority patent/PL336942A1/en
Priority to TR1999/02883T priority patent/TR199902883T2/en
Priority to JP54996798A priority patent/JP2002500645A/en
Priority to CA002291111A priority patent/CA2291111A1/en
Priority to IDW991432A priority patent/ID22876A/en
Priority to BR9809652-4A priority patent/BR9809652A/en
Priority to CN98807356A priority patent/CN1264378A/en
Priority to EP98932069A priority patent/EP0983262B1/en
Priority to EA199901062A priority patent/EA199901062A1/en
Priority to IL13303698A priority patent/IL133036A0/en
Priority to SK1592-99A priority patent/SK159299A3/en
Priority to APAP/P/1999/001695A priority patent/AP9901695A0/en
Priority to AT98932069T priority patent/ATE244711T1/en
Priority to AU82098/98A priority patent/AU8209898A/en
Priority to DE69816290T priority patent/DE69816290T2/en
Priority to ES98932069T priority patent/ES2201509T3/en
Priority to PCT/EP1998/003014 priority patent/WO1998052942A1/en
Priority to HU0002300A priority patent/HUP0002300A3/en
Priority to DZ980108A priority patent/DZ2498A1/en
Priority to PE1998000398A priority patent/PE75199A1/en
Priority to MA25086A priority patent/MA26501A1/en
Priority to ARP980102363A priority patent/AR012732A1/en
Priority to CO98029024A priority patent/CO4950515A1/en
Publication of ITMI972775A1 publication Critical patent/ITMI972775A1/en
Application granted granted Critical
Publication of IT1296976B1 publication Critical patent/IT1296976B1/en
Priority to NO995711A priority patent/NO995711L/en
Priority to OA9900253A priority patent/OA11515A/en
Priority to BG104009A priority patent/BG104009A/en
Priority to US09/731,190 priority patent/US20010012846A1/en
Priority to US10/052,925 priority patent/US20030004183A1/en
Priority to US10/721,644 priority patent/US20040116469A1/en
Priority to US11/085,028 priority patent/US20050159428A1/en
Priority to US11/418,274 priority patent/US20060205735A1/en
Priority to US11/691,899 priority patent/US20070197546A1/en

Links

Abstract

Quinoline-4-N-arylmethylcarboxamides of formula (I) and their salts and solvates are new: Ar = aryl or heteroaryl (both optionally substituted), or 5-7C cycloalkyl or cycloalkadienyl; R = 1-6C alkyl, hydroxyalkyl, aminoalkyl, halogenoalkyl, alkoxyalkyl, 3-7C cycloalkyl, 3-7C cycloalkyl alkyl, phenyl, phenyl 1-6C alkyl, mono- or di- (1-6C alkyl)aminoalkyl, 1-6C acylaminoalkyl, carboxy, 2-7C alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, 2-7C alkoxycarbonyl 1-6C alkyl, or mono- or di- (1-6C alkyl)aminocarbonyl; or R= 2-3C alkylene bonded to Ar; m = 1-4; R1 = H, 1-6C alkyl, alkoxy, hydroxyalkyl, 2-6C alkenyl, aryl, hydroxy, halogen, nitro, cyano, carboxy, carboxamido, sulphonamido, 2-7C alkoxycarbonyl, CF3, acyloxy, phthalimido, amino, or mono- or di- (1-6C alkyl)amino; R2 = (CH2)nNY1Y2; n = 1-9; Y1, Y2 = H, 1-6C alkyl, hydroxyalkyl, mono- or di- (1-6C alkyl)amino, 2-6C alkenyl, aryl, or aryl 1-6C alkyl; or NY1Y2 = mono- or fused azacyclic ring; R3 = 1-6C alkyl, 3-7C cycloalkyl, 4-7C cycloalkylalkyl, or heteroaryl; and R4 = H or 1-6C alkyl.
ITMI972775 1997-05-23 1997-12-16 New quinoline arylmethylcarboxamide are NK-2 and NK-3 receptor antagonists - useful for treating asthma, arthritis, dermatitis, organ transplant, anxiety, depression, angina, pain, Alzheimer's disease IT1296976B1 (en)

Priority Applications (33)

Application Number Priority Date Filing Date Title
ITMI972775 IT1296976B1 (en) 1997-12-16 1997-12-16 New quinoline arylmethylcarboxamide are NK-2 and NK-3 receptor antagonists - useful for treating asthma, arthritis, dermatitis, organ transplant, anxiety, depression, angina, pain, Alzheimer's disease
HU0002300A HUP0002300A3 (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives, process for producing them, pharmaceutical compositions containing them and their use
JP54996798A JP2002500645A (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists
TR1999/02883T TR199902883T2 (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists.
IDW991432A ID22876A (en) 1997-05-23 1998-05-18 QUINOLIN-4-CARBOXAMIDE DEGREE AS RECIPIENT OF NK-2 AND NK-3 ANTAGONISTS
PCT/EP1998/003014 WO1998052942A1 (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists
CN98807356A CN1264378A (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists
EP98932069A EP0983262B1 (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists
EA199901062A EA199901062A1 (en) 1997-05-23 1998-05-18 QUINOLIN-4-CARBOXAMIDE DERIVATIVES AS ANTAGONISTS OF NK-2 AND NK-3 RECEPTORS
IL13303698A IL133036A0 (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists
SK1592-99A SK159299A3 (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists
APAP/P/1999/001695A AP9901695A0 (en) 1997-05-23 1998-05-18 Quinoline-4-carbaoxamide derivatives as NK-2 and NK-3 receptor antagonists.
AT98932069T ATE244711T1 (en) 1997-05-23 1998-05-18 QUINOLINE-4-CARBOXAMIDE DERIVATIVES AS NK-2 AND NK-3 RECEPTOR ANTAGONISTS
AU82098/98A AU8209898A (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists
DE69816290T DE69816290T2 (en) 1997-05-23 1998-05-18 CHINOLIN-4-CARBOXAMIDE DERIVATIVES AS NK-2 AND NK-3 RECEPTOR ANTAGONISTS
ES98932069T ES2201509T3 (en) 1997-05-23 1998-05-18 DERIVATIVES OF QUINOLINA-4-CARBOXAMIDE AS AN ANTAGONIST OF THE NK-2 AND NK-3 RECEPTORS.
PL98336942A PL336942A1 (en) 1997-05-23 1998-05-18 Derivatives of quinoline-4-carboxamide as antagonists of nk-2 and nk-3 receptor
CA002291111A CA2291111A1 (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists
BR9809652-4A BR9809652A (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists
DZ980108A DZ2498A1 (en) 1997-05-23 1998-05-19 New quinoline derivatives process for their preparation and pharmaceutical compositions containing them.
PE1998000398A PE75199A1 (en) 1997-05-23 1998-05-20 QUINOLINE DERIVATIVE USEFUL AS A NEUROQUININE ANTAGONIST
ARP980102363A AR012732A1 (en) 1997-05-23 1998-05-21 DERIVATIVES OF PHENYLQUINOLINS, PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE FOR THE MANUFACTURE OF MEDICINES
MA25086A MA26501A1 (en) 1997-05-23 1998-05-21 NEW QUINOLEIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CO98029024A CO4950515A1 (en) 1997-05-23 1998-05-22 NEW DERIVATIVES OF QUINOLINE FOR MEDICINAL USE
NO995711A NO995711L (en) 1997-05-23 1999-11-22 Quinoline-4-carboxamide derivatives such as NK-2 and NK-3 receptor antagonists
OA9900253A OA11515A (en) 1997-05-23 1999-11-23 Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists.
BG104009A BG104009A (en) 1997-05-23 1999-12-14 Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists
US09/731,190 US20010012846A1 (en) 1997-05-23 2000-12-06 Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists
US10/052,925 US20030004183A1 (en) 1997-05-23 2002-01-16 Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists
US10/721,644 US20040116469A1 (en) 1997-05-23 2003-11-25 Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists
US11/085,028 US20050159428A1 (en) 1997-05-23 2005-03-14 Quinoline-4-carboxamide derivatives asNK-2 and NK-3 receptor antagonists
US11/418,274 US20060205735A1 (en) 1997-05-23 2006-05-04 Quinoline-4-carboxamide as NK-2 and NK-3 receptor antagonists
US11/691,899 US20070197546A1 (en) 1997-05-23 2007-03-27 Quinoline-4-carboxamide as nk-2 and nk-3 receptor antagonists

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI972775 IT1296976B1 (en) 1997-12-16 1997-12-16 New quinoline arylmethylcarboxamide are NK-2 and NK-3 receptor antagonists - useful for treating asthma, arthritis, dermatitis, organ transplant, anxiety, depression, angina, pain, Alzheimer's disease

Publications (2)

Publication Number Publication Date
ITMI972775A1 ITMI972775A1 (en) 1999-06-16
IT1296976B1 true IT1296976B1 (en) 1999-08-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI972775 IT1296976B1 (en) 1997-05-23 1997-12-16 New quinoline arylmethylcarboxamide are NK-2 and NK-3 receptor antagonists - useful for treating asthma, arthritis, dermatitis, organ transplant, anxiety, depression, angina, pain, Alzheimer's disease

Country Status (1)

Country Link
IT (1) IT1296976B1 (en)

Also Published As

Publication number Publication date
ITMI972775A1 (en) 1999-06-16

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