IT1296976B1 - New quinoline arylmethylcarboxamide are NK-2 and NK-3 receptor antagonists - useful for treating asthma, arthritis, dermatitis, organ transplant, anxiety, depression, angina, pain, Alzheimer's disease - Google Patents
New quinoline arylmethylcarboxamide are NK-2 and NK-3 receptor antagonists - useful for treating asthma, arthritis, dermatitis, organ transplant, anxiety, depression, angina, pain, Alzheimer's diseaseInfo
- Publication number
- IT1296976B1 IT1296976B1 ITMI972775A IT1296976B1 IT 1296976 B1 IT1296976 B1 IT 1296976B1 IT MI972775 A ITMI972775 A IT MI972775A IT 1296976 B1 IT1296976 B1 IT 1296976B1
- Authority
- IT
- Italy
- Prior art keywords
- alkyl
- mono
- arylmethylcarboxamide
- angina
- dermatitis
- Prior art date
Links
Abstract
Quinoline-4-N-arylmethylcarboxamides of formula (I) and their salts and solvates are new: Ar = aryl or heteroaryl (both optionally substituted), or 5-7C cycloalkyl or cycloalkadienyl; R = 1-6C alkyl, hydroxyalkyl, aminoalkyl, halogenoalkyl, alkoxyalkyl, 3-7C cycloalkyl, 3-7C cycloalkyl alkyl, phenyl, phenyl 1-6C alkyl, mono- or di- (1-6C alkyl)aminoalkyl, 1-6C acylaminoalkyl, carboxy, 2-7C alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, 2-7C alkoxycarbonyl 1-6C alkyl, or mono- or di- (1-6C alkyl)aminocarbonyl; or R= 2-3C alkylene bonded to Ar; m = 1-4; R1 = H, 1-6C alkyl, alkoxy, hydroxyalkyl, 2-6C alkenyl, aryl, hydroxy, halogen, nitro, cyano, carboxy, carboxamido, sulphonamido, 2-7C alkoxycarbonyl, CF3, acyloxy, phthalimido, amino, or mono- or di- (1-6C alkyl)amino; R2 = (CH2)nNY1Y2; n = 1-9; Y1, Y2 = H, 1-6C alkyl, hydroxyalkyl, mono- or di- (1-6C alkyl)amino, 2-6C alkenyl, aryl, or aryl 1-6C alkyl; or NY1Y2 = mono- or fused azacyclic ring; R3 = 1-6C alkyl, 3-7C cycloalkyl, 4-7C cycloalkylalkyl, or heteroaryl; and R4 = H or 1-6C alkyl.
Priority Applications (33)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI972775 IT1296976B1 (en) | 1997-12-16 | 1997-12-16 | New quinoline arylmethylcarboxamide are NK-2 and NK-3 receptor antagonists - useful for treating asthma, arthritis, dermatitis, organ transplant, anxiety, depression, angina, pain, Alzheimer's disease |
HU0002300A HUP0002300A3 (en) | 1997-05-23 | 1998-05-18 | Quinoline-4-carboxamide derivatives, process for producing them, pharmaceutical compositions containing them and their use |
JP54996798A JP2002500645A (en) | 1997-05-23 | 1998-05-18 | Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists |
TR1999/02883T TR199902883T2 (en) | 1997-05-23 | 1998-05-18 | Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists. |
IDW991432A ID22876A (en) | 1997-05-23 | 1998-05-18 | QUINOLIN-4-CARBOXAMIDE DEGREE AS RECIPIENT OF NK-2 AND NK-3 ANTAGONISTS |
PCT/EP1998/003014 WO1998052942A1 (en) | 1997-05-23 | 1998-05-18 | Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists |
CN98807356A CN1264378A (en) | 1997-05-23 | 1998-05-18 | Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists |
EP98932069A EP0983262B1 (en) | 1997-05-23 | 1998-05-18 | Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists |
EA199901062A EA199901062A1 (en) | 1997-05-23 | 1998-05-18 | QUINOLIN-4-CARBOXAMIDE DERIVATIVES AS ANTAGONISTS OF NK-2 AND NK-3 RECEPTORS |
IL13303698A IL133036A0 (en) | 1997-05-23 | 1998-05-18 | Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists |
SK1592-99A SK159299A3 (en) | 1997-05-23 | 1998-05-18 | Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists |
APAP/P/1999/001695A AP9901695A0 (en) | 1997-05-23 | 1998-05-18 | Quinoline-4-carbaoxamide derivatives as NK-2 and NK-3 receptor antagonists. |
AT98932069T ATE244711T1 (en) | 1997-05-23 | 1998-05-18 | QUINOLINE-4-CARBOXAMIDE DERIVATIVES AS NK-2 AND NK-3 RECEPTOR ANTAGONISTS |
AU82098/98A AU8209898A (en) | 1997-05-23 | 1998-05-18 | Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists |
DE69816290T DE69816290T2 (en) | 1997-05-23 | 1998-05-18 | CHINOLIN-4-CARBOXAMIDE DERIVATIVES AS NK-2 AND NK-3 RECEPTOR ANTAGONISTS |
ES98932069T ES2201509T3 (en) | 1997-05-23 | 1998-05-18 | DERIVATIVES OF QUINOLINA-4-CARBOXAMIDE AS AN ANTAGONIST OF THE NK-2 AND NK-3 RECEPTORS. |
PL98336942A PL336942A1 (en) | 1997-05-23 | 1998-05-18 | Derivatives of quinoline-4-carboxamide as antagonists of nk-2 and nk-3 receptor |
CA002291111A CA2291111A1 (en) | 1997-05-23 | 1998-05-18 | Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists |
BR9809652-4A BR9809652A (en) | 1997-05-23 | 1998-05-18 | Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists |
DZ980108A DZ2498A1 (en) | 1997-05-23 | 1998-05-19 | New quinoline derivatives process for their preparation and pharmaceutical compositions containing them. |
PE1998000398A PE75199A1 (en) | 1997-05-23 | 1998-05-20 | QUINOLINE DERIVATIVE USEFUL AS A NEUROQUININE ANTAGONIST |
ARP980102363A AR012732A1 (en) | 1997-05-23 | 1998-05-21 | DERIVATIVES OF PHENYLQUINOLINS, PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE FOR THE MANUFACTURE OF MEDICINES |
MA25086A MA26501A1 (en) | 1997-05-23 | 1998-05-21 | NEW QUINOLEIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
CO98029024A CO4950515A1 (en) | 1997-05-23 | 1998-05-22 | NEW DERIVATIVES OF QUINOLINE FOR MEDICINAL USE |
NO995711A NO995711L (en) | 1997-05-23 | 1999-11-22 | Quinoline-4-carboxamide derivatives such as NK-2 and NK-3 receptor antagonists |
OA9900253A OA11515A (en) | 1997-05-23 | 1999-11-23 | Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists. |
BG104009A BG104009A (en) | 1997-05-23 | 1999-12-14 | Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists |
US09/731,190 US20010012846A1 (en) | 1997-05-23 | 2000-12-06 | Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists |
US10/052,925 US20030004183A1 (en) | 1997-05-23 | 2002-01-16 | Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists |
US10/721,644 US20040116469A1 (en) | 1997-05-23 | 2003-11-25 | Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists |
US11/085,028 US20050159428A1 (en) | 1997-05-23 | 2005-03-14 | Quinoline-4-carboxamide derivatives asNK-2 and NK-3 receptor antagonists |
US11/418,274 US20060205735A1 (en) | 1997-05-23 | 2006-05-04 | Quinoline-4-carboxamide as NK-2 and NK-3 receptor antagonists |
US11/691,899 US20070197546A1 (en) | 1997-05-23 | 2007-03-27 | Quinoline-4-carboxamide as nk-2 and nk-3 receptor antagonists |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI972775 IT1296976B1 (en) | 1997-12-16 | 1997-12-16 | New quinoline arylmethylcarboxamide are NK-2 and NK-3 receptor antagonists - useful for treating asthma, arthritis, dermatitis, organ transplant, anxiety, depression, angina, pain, Alzheimer's disease |
Publications (2)
Publication Number | Publication Date |
---|---|
ITMI972775A1 ITMI972775A1 (en) | 1999-06-16 |
IT1296976B1 true IT1296976B1 (en) | 1999-08-03 |
Family
ID=11378373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI972775 IT1296976B1 (en) | 1997-05-23 | 1997-12-16 | New quinoline arylmethylcarboxamide are NK-2 and NK-3 receptor antagonists - useful for treating asthma, arthritis, dermatitis, organ transplant, anxiety, depression, angina, pain, Alzheimer's disease |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1296976B1 (en) |
-
1997
- 1997-12-16 IT ITMI972775 patent/IT1296976B1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITMI972775A1 (en) | 1999-06-16 |
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