IT1295309B1 - Preparation of new and known aminocarbonyl geneseroline derivatives - for use as acetylcholinesterase inhibitors - Google Patents
Preparation of new and known aminocarbonyl geneseroline derivatives - for use as acetylcholinesterase inhibitorsInfo
- Publication number
- IT1295309B1 IT1295309B1 ITMI972299A IT1295309B1 IT 1295309 B1 IT1295309 B1 IT 1295309B1 IT MI972299 A ITMI972299 A IT MI972299A IT 1295309 B1 IT1295309 B1 IT 1295309B1
- Authority
- IT
- Italy
- Prior art keywords
- geneseroline
- preparation
- aminocarbonyl
- derivatives
- new
- Prior art date
Links
Landscapes
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Preparation of aminocarbonyl derivatives of geneseroline (I) comprises oxidation of eserine, followed by hydrolysis to geneseroline, without isolating the intermediate geneserine, followed by acylation of geneseroline with an isocyanate and optional conversion to a salt. - Preparation of aminocarbonyl derivatives of geneseroline of formula (I) comprises: (a) oxidation of eserine with hydrogen peroxide in the presence of a base; (b) hydrolysis of the intermediate geneserine without isolation to give geneseroline; (c) acylation geneseroline with an isocyanate of formula R-N=C=O in the presence of a basic catalyst; and (d) optionally conversion into a salt. R = 2-20C alkyl, 3-7C cycloalkyl, phenyl or benzyl optionally substituted by 1-4C alkyl, halo or 1-4C alkoxy.
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT002299 IT1295309B1 (en) | 1997-10-10 | 1997-10-10 | Preparation of new and known aminocarbonyl geneseroline derivatives - for use as acetylcholinesterase inhibitors |
SK503-2000A SK5032000A3 (en) | 1997-10-10 | 1998-10-07 | A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity, pharmaceutical composition containing the same, use thereof and intermediates |
NZ503773A NZ503773A (en) | 1997-10-10 | 1998-10-07 | A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity |
HU0003747A HUP0003747A3 (en) | 1997-10-10 | 1998-10-07 | A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity |
CA002274658A CA2274658A1 (en) | 1997-10-10 | 1998-10-07 | A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity |
EP98954370A EP1023297A1 (en) | 1997-10-10 | 1998-10-07 | A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity |
CN98810683A CN1278264A (en) | 1997-10-10 | 1998-10-07 | Process for prepn. of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity |
KR1020007003805A KR20010015714A (en) | 1997-10-10 | 1998-10-07 | A Process for the Preparation of Aminocarbonyl Derivatives of Geneseroline Having Selective Brain Anticholinesterase Activity |
PCT/EP1998/006377 WO1999019329A1 (en) | 1997-10-10 | 1998-10-07 | A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity |
IL13539998A IL135399A0 (en) | 1997-10-10 | 1998-10-07 | A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity |
PL98339761A PL339761A1 (en) | 1997-10-10 | 1998-10-07 | Method of obtaining aminocabonylic genezerolin of selective activity against cerebral cholinesterase |
EA200000300A EA003192B1 (en) | 1997-10-10 | 1998-10-07 | A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity |
TR2000/00951T TR200000951T2 (en) | 1997-10-10 | 1998-10-07 | A process for the preparation of aminocarbonyl derivatives of geneserol with selective brain anticholinesterase activity. |
BR9815237-8A BR9815237A (en) | 1997-10-10 | 1998-10-07 | Process for preparing aminocarbonyl derivatives of geneseroline that have selective anticholinesterase activity in the brain |
US09/319,693 US6297237B1 (en) | 1997-10-10 | 1998-10-07 | Process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity |
AU11516/99A AU750964B2 (en) | 1997-10-10 | 1998-10-07 | A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity |
ARP980105062A AR018511A1 (en) | 1997-10-10 | 1998-10-09 | PROCESS TO PREPARE AMINOCARBONILE DERIVATIVES OF GENESEROLINE, PHARMACEUTICAL COMPOSITION CONTAINING THEM, INTERMEDIARY COMPOUNDS CONTAINING GENINERARBONYL DERIVATIVES OF GENESEROLINE AND THE USE OF SUCH COMPOUNDS |
ZA989237A ZA989237B (en) | 1997-10-10 | 1998-10-09 | A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity |
TW087117571A TW490467B (en) | 1997-10-10 | 1998-10-23 | A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT002299 IT1295309B1 (en) | 1997-10-10 | 1997-10-10 | Preparation of new and known aminocarbonyl geneseroline derivatives - for use as acetylcholinesterase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
ITMI972299A1 ITMI972299A1 (en) | 1999-04-10 |
IT1295309B1 true IT1295309B1 (en) | 1999-05-04 |
Family
ID=11378023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT002299 IT1295309B1 (en) | 1997-10-10 | 1997-10-10 | Preparation of new and known aminocarbonyl geneseroline derivatives - for use as acetylcholinesterase inhibitors |
Country Status (2)
Country | Link |
---|---|
IT (1) | IT1295309B1 (en) |
ZA (1) | ZA989237B (en) |
-
1997
- 1997-10-10 IT IT002299 patent/IT1295309B1/en active IP Right Grant
-
1998
- 1998-10-09 ZA ZA989237A patent/ZA989237B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA989237B (en) | 1999-04-19 |
ITMI972299A1 (en) | 1999-04-10 |
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