IT1286663B1 - PROTEIN CAPABLE OF INHIBITING RIBOSOMIAL ACTIVITY, ITS PREPARATION AND USE AS A CHEMICAL OR RECOMBINANT IMMUNOCONUGATE AND SEQUENCE OF CDNA - Google Patents

PROTEIN CAPABLE OF INHIBITING RIBOSOMIAL ACTIVITY, ITS PREPARATION AND USE AS A CHEMICAL OR RECOMBINANT IMMUNOCONUGATE AND SEQUENCE OF CDNA

Info

Publication number
IT1286663B1
IT1286663B1 IT96FI000155A ITFI960155A IT1286663B1 IT 1286663 B1 IT1286663 B1 IT 1286663B1 IT 96FI000155 A IT96FI000155 A IT 96FI000155A IT FI960155 A ITFI960155 A IT FI960155A IT 1286663 B1 IT1286663 B1 IT 1286663B1
Authority
IT
Italy
Prior art keywords
ribosomial
immunoconugate
cdna
recombinant
inhibiting
Prior art date
Application number
IT96FI000155A
Other languages
Italian (it)
Inventor
Antonio Mele
Santis Rita De
Dino Parente
Maria Ines Colnaghi
Original Assignee
Ministero Uni Ricerca Scient E
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ministero Uni Ricerca Scient E filed Critical Ministero Uni Ricerca Scient E
Priority to IT96FI000155A priority Critical patent/IT1286663B1/en
Priority to PCT/EP1997/003359 priority patent/WO1997049726A1/en
Priority to AU34375/97A priority patent/AU3437597A/en
Publication of ITFI960155A1 publication Critical patent/ITFI960155A1/en
Application granted granted Critical
Publication of IT1286663B1 publication Critical patent/IT1286663B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6819—Plant toxins
    • A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT96FI000155A 1996-06-27 1996-06-27 PROTEIN CAPABLE OF INHIBITING RIBOSOMIAL ACTIVITY, ITS PREPARATION AND USE AS A CHEMICAL OR RECOMBINANT IMMUNOCONUGATE AND SEQUENCE OF CDNA IT1286663B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT96FI000155A IT1286663B1 (en) 1996-06-27 1996-06-27 PROTEIN CAPABLE OF INHIBITING RIBOSOMIAL ACTIVITY, ITS PREPARATION AND USE AS A CHEMICAL OR RECOMBINANT IMMUNOCONUGATE AND SEQUENCE OF CDNA
PCT/EP1997/003359 WO1997049726A1 (en) 1996-06-27 1997-06-26 Recombinant ribosomal inhibitor protein (rip) and use as immunoconjugate
AU34375/97A AU3437597A (en) 1996-06-27 1997-06-26 Recombinant ribosomal inhibitor protein (rip) and use as immunoconjugate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96FI000155A IT1286663B1 (en) 1996-06-27 1996-06-27 PROTEIN CAPABLE OF INHIBITING RIBOSOMIAL ACTIVITY, ITS PREPARATION AND USE AS A CHEMICAL OR RECOMBINANT IMMUNOCONUGATE AND SEQUENCE OF CDNA

Publications (2)

Publication Number Publication Date
ITFI960155A1 ITFI960155A1 (en) 1997-12-27
IT1286663B1 true IT1286663B1 (en) 1998-07-15

Family

ID=11351738

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96FI000155A IT1286663B1 (en) 1996-06-27 1996-06-27 PROTEIN CAPABLE OF INHIBITING RIBOSOMIAL ACTIVITY, ITS PREPARATION AND USE AS A CHEMICAL OR RECOMBINANT IMMUNOCONUGATE AND SEQUENCE OF CDNA

Country Status (3)

Country Link
AU (1) AU3437597A (en)
IT (1) IT1286663B1 (en)
WO (1) WO1997049726A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812327B1 (en) 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
DE19946142A1 (en) * 1999-09-27 2001-03-29 Bundesrepublik Deutschland Let Cell-targeting vector selective for T lymphocytes, useful in gene therapy of e.g. acquired immune deficiency syndrome, encodes a single-chain variable antibody fragment
AU6842701A (en) 2000-06-16 2002-01-14 Human Genome Sciences Inc Antibodies that immunospecifically bind to blys
EP1174506A1 (en) * 2000-06-28 2002-01-23 Stichting Dienst Landbouwkundig Onderzoek C-terminal Erns peptide and analogues thereof
US20030091565A1 (en) 2000-08-18 2003-05-15 Beltzer James P. Binding polypeptides and methods based thereon
JP2004533997A (en) 2001-02-20 2004-11-11 ザイモジェネティクス，インコーポレイティド Antibodies that bind both BCMA and TACI
EP1497415B1 (en) 2002-04-19 2010-12-29 ZymoGenetics, L.L.C. Methods for detection or modulation of the interaction of a cytokine receptor with its ligand
US9168286B2 (en) 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
WO2007123765A2 (en) 2006-03-31 2007-11-01 Human Genome Sciences Inc. Neutrokine-alpha and neutrokine-alpha splice variant

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE62463B1 (en) * 1988-07-07 1995-02-08 Res Dev Foundation Immunoconjugates for cancer diagnosis and therapy
JP2518732B2 (en) * 1990-02-22 1996-07-31 株式会社大塚製薬工場 α-sarcin gene
KR920702229A (en) * 1990-06-29 1992-09-03 마에다 카쯔노스케 Immunotoxin complex
AU654563B2 (en) * 1991-07-24 1994-11-10 Imperial Chemical Industries Plc Proteins
DK1136556T3 (en) * 1991-11-25 2005-10-03 Enzon Inc Process for the preparation of multivalent antigen-binding proteins
US5597569A (en) * 1993-10-25 1997-01-28 Bristol-Myers Squibb Company Bryodin 2 a ribosome-inactivating protein isolated from the plant Bryonia dioica
GB9324807D0 (en) * 1993-12-03 1994-01-19 Cancer Res Campaign Tech Tumour antibody

Also Published As

Publication number Publication date
AU3437597A (en) 1998-01-14
ITFI960155A1 (en) 1997-12-27
WO1997049726A1 (en) 1997-12-31

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Legal Events

Date Code Title Description
0001 Granted