IT1281857B1 - Process for the preparation of microspheres through the use of supercritical fluids - Google Patents

Process for the preparation of microspheres through the use of supercritical fluids

Info

Publication number
IT1281857B1
IT1281857B1 IT95PD000065A ITPD950065A IT1281857B1 IT 1281857 B1 IT1281857 B1 IT 1281857B1 IT 95PD000065 A IT95PD000065 A IT 95PD000065A IT PD950065 A ITPD950065 A IT PD950065A IT 1281857 B1 IT1281857 B1 IT 1281857B1
Authority
IT
Italy
Prior art keywords
microspheres
preparation
supercritical
supercritical fluids
drugs
Prior art date
Application number
IT95PD000065A
Other languages
Italian (it)
Inventor
Paolo Pallado
Luca Benedetti
Lanfranco Callegaro
Original Assignee
Fidia Advanced Biopolymers Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl
Publication of ITPD950065A0 publication Critical patent/ITPD950065A0/en
Priority to IT95PD000065A priority Critical patent/IT1281857B1/en
Priority to ES96909138T priority patent/ES2170853T3/en
Priority to EP96909138A priority patent/EP0817620B1/en
Priority to CA002216919A priority patent/CA2216919C/en
Priority to DE69618938T priority patent/DE69618938T2/en
Priority to AU52749/96A priority patent/AU695207B2/en
Priority to AT96909138T priority patent/ATE212545T1/en
Priority to PCT/EP1996/001354 priority patent/WO1996029998A1/en
Publication of ITPD950065A1 publication Critical patent/ITPD950065A1/en
Priority to US08/938,288 priority patent/US6214384B1/en
Priority claimed from US08/938,288 external-priority patent/US6214384B1/en
Application granted granted Critical
Publication of IT1281857B1 publication Critical patent/IT1281857B1/en
Priority to US09/558,801 priority patent/US6541035B1/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

This invention relates to a process for the preparation of polymer microspheres through the use of supercritical fluids (SCF). The process comprises a stage in which the liquid solution with a variable concentration of polymer, preferably the ester of an acid polysaccharide, is swollen by supercritical solvent. The technique, known as precipitation induced by a supercritical antisolvent (SAS), makes it possible to incorporate drugs of particular interest in the biomedical field into microspheres as systems for delivery of the drugs, and contrast agents and carriers for use in the diagnostic field.
IT95PD000065A 1995-03-28 1995-03-28 Process for the preparation of microspheres through the use of supercritical fluids IT1281857B1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT95PD000065A IT1281857B1 (en) 1995-03-28 1995-03-28 Process for the preparation of microspheres through the use of supercritical fluids
EP96909138A EP0817620B1 (en) 1995-03-28 1996-03-26 Nanospheres comprising a biocompatible polysaccharide
ES96909138T ES2170853T3 (en) 1995-03-28 1996-03-26 NANOSPHERES THAT UNDERSTAND A BIOCOMPATIBLE POLISACARIDE.
CA002216919A CA2216919C (en) 1995-03-28 1996-03-26 Nanospheres comprising a biocompatible polysaccharide
DE69618938T DE69618938T2 (en) 1995-03-28 1996-03-26 NANOSPHERES WITH A BIO-COMPATIBLE POLYSACCHARIDE
AU52749/96A AU695207B2 (en) 1995-03-28 1996-03-26 Nanospheres comprising a biocompatible polysaccharide
AT96909138T ATE212545T1 (en) 1995-03-28 1996-03-26 NANOSPHERES WITH A BIOCOMPATIBLE POLYSACCHARIDE
PCT/EP1996/001354 WO1996029998A1 (en) 1995-03-28 1996-03-26 Nanospheres comprising a biocompatible polysaccharide
US08/938,288 US6214384B1 (en) 1995-03-28 1997-09-26 Nanosheres comprising a biocompatible polysaccharide
US09/558,801 US6541035B1 (en) 1995-03-28 2000-04-26 Nanosheres comprising a biocompatible polysaccharide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95PD000065A IT1281857B1 (en) 1995-03-28 1995-03-28 Process for the preparation of microspheres through the use of supercritical fluids
US08/938,288 US6214384B1 (en) 1995-03-28 1997-09-26 Nanosheres comprising a biocompatible polysaccharide

Publications (3)

Publication Number Publication Date
ITPD950065A0 ITPD950065A0 (en) 1995-03-28
ITPD950065A1 ITPD950065A1 (en) 1996-09-28
IT1281857B1 true IT1281857B1 (en) 1998-03-03

Family

ID=26331827

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95PD000065A IT1281857B1 (en) 1995-03-28 1995-03-28 Process for the preparation of microspheres through the use of supercritical fluids

Country Status (1)

Country Link
IT (1) IT1281857B1 (en)

Also Published As

Publication number Publication date
ITPD950065A0 (en) 1995-03-28
ITPD950065A1 (en) 1996-09-28

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19990210