IT1272878B - Indole compounds - Google Patents
Indole compoundsInfo
- Publication number
- IT1272878B IT1272878B ITMI950030A ITMI950030A IT1272878B IT 1272878 B IT1272878 B IT 1272878B IT MI950030 A ITMI950030 A IT MI950030A IT MI950030 A ITMI950030 A IT MI950030A IT 1272878 B IT1272878 B IT 1272878B
- Authority
- IT
- Italy
- Prior art keywords
- alkyl
- phenyl
- hydrogen
- substituted
- formula
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
- -1 hydroxy, amino Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
The compound of formula I: <IMAGE> or its salt or solvate in which: (i) Ra is hydrogen, alkyl or phenyl and Rb is a residue of formula (a): <IMAGE> in which X is hydroxy or alkoxy or X is the NRsRt group in which Rs and Rt are each separately hydrogen, alkyl, substituted alkyl, phenyl alkyl or heteroalkyl, R1 is alkyl or substituted or unsubstituted phenyl, and R2, R3 and R4 are each separately hydrogen, alkyl or phenyl, or (ii) Ra is a residue of formula (a) and Rb is hydrogen, alkyl or phenyl, R6 and R7 are each separately hydrogen, hydroxy, amino, alkoxy, substituted or unsubstituted phenoxy, substituted or unsubstituted benzyloxy, alkyl amino, dialkyl amino, chloro, alkyl, carboxy, carbalkoxy, carbamoyl, alkyl carbamoyl, or R6 and R7 are both methylene dioxy, carbonyl dioxy or carbonyl diamino, and R8 is hydrogen, alkanoyl or alkyl, are used for the treatment of osteoporosis.
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI950030A IT1272878B (en) | 1995-01-10 | 1995-01-10 | Indole compounds |
APAP/P/1997/001029A AP648A (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis. |
SK932-97A SK93297A3 (en) | 1995-01-10 | 1996-01-08 | Indole derivatives, method for their producing, pharmaceutical comosition containing the same, and their use |
CA002209936A CA2209936A1 (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis |
US08/860,760 US5981525A (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis |
JP8521450A JPH10512251A (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful for treating osteoporosis |
TR97/00625T TR199700625T1 (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis (bone loss). |
HU9901096A HUP9901096A3 (en) | 1995-01-10 | 1996-01-08 | Indole derivatives, preparation and use thereof, pharmaceutical composition containing these compounds |
AU45360/96A AU4536096A (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis |
BR9606743A BR9606743A (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis |
PCT/EP1996/000157 WO1996021644A1 (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis |
CZ972176A CZ217697A3 (en) | 1995-01-10 | 1996-01-08 | Indole derivatives, which can be used for treating osteoporosis, process of their preparation, pharmaceutical composition containing such derivatives and use |
PL96321263A PL321263A1 (en) | 1995-01-10 | 1996-01-08 | Derivatives of indole useful in treating osteoporosis |
EP96901275A EP0802902A1 (en) | 1995-01-10 | 1996-01-08 | Indole derivatives useful in the treatment of osteoporosis |
KR1019970704719A KR19980701330A (en) | 1995-01-10 | 1996-01-08 | Indole Derivatives Useful in the Treatment of Osteoporosis (Indole Derivatives Useful in the Treatment of Osteoporosis) |
ZA96121A ZA96121B (en) | 1995-01-10 | 1996-01-09 | Novel compounds |
BG101769A BG101769A (en) | 1995-01-10 | 1997-07-07 | Indole derivatives useful in the treatment of osteoporosis |
FI972919A FI972919A (en) | 1995-01-10 | 1997-07-09 | Indole derivatives useful in the treatment of osteoporosis |
NO973178A NO973178L (en) | 1995-01-10 | 1997-07-09 | Indole derivatives useful in the treatment of osteoporosis |
OA70046A OA10611A (en) | 1995-01-10 | 1997-07-09 | Indole derivatives useful in the treatment of osteoporosis |
MXPA/A/1997/005243A MXPA97005243A (en) | 1995-01-10 | 1997-07-10 | Derivatives of indol and compositions of the same useful in the treatment of osteoporo |
EA199700098A EA199700098A1 (en) | 1995-01-10 | 1997-08-08 | INDOL DERIVATIVES SUITABLE FOR THE TREATMENT OF OSTEOPOROSIS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI950030A IT1272878B (en) | 1995-01-10 | 1995-01-10 | Indole compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI950030A0 ITMI950030A0 (en) | 1995-01-10 |
ITMI950030A1 ITMI950030A1 (en) | 1996-07-10 |
IT1272878B true IT1272878B (en) | 1997-07-01 |
Family
ID=11370165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI950030A IT1272878B (en) | 1995-01-10 | 1995-01-10 | Indole compounds |
Country Status (2)
Country | Link |
---|---|
IT (1) | IT1272878B (en) |
ZA (1) | ZA96121B (en) |
-
1995
- 1995-01-10 IT ITMI950030A patent/IT1272878B/en active IP Right Grant
-
1996
- 1996-01-09 ZA ZA96121A patent/ZA96121B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ITMI950030A0 (en) | 1995-01-10 |
ZA96121B (en) | 1997-07-09 |
ITMI950030A1 (en) | 1996-07-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |