IT1271485B - Retroinverted peptides having immunomodulating activity - Google Patents
Retroinverted peptides having immunomodulating activityInfo
- Publication number
- IT1271485B IT1271485B ITMI932153A ITMI932153A IT1271485B IT 1271485 B IT1271485 B IT 1271485B IT MI932153 A ITMI932153 A IT MI932153A IT MI932153 A ITMI932153 A IT MI932153A IT 1271485 B IT1271485 B IT 1271485B
- Authority
- IT
- Italy
- Prior art keywords
- leu
- peptides
- terminal
- immunomodulating activity
- optionally amidated
- Prior art date
Links
- 230000002519 immonomodulatory effect Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
[1,2]-retro-inverso-peptides of formula I A1-A2-A3-A4 where A1 is gGly, gThr, gLeu, gIle, gVal, gSar or gAla; A2 is mLeu, mIle, mVal, mArg, mLys or mOrn, A3 is Pro, Leu, Ile and Val, optionally amidated at the terminal C, A4 is Arg, Leu and Gln optionally amidated at the terminal C, or is absent, these residues being in the D or L form at the carbon atom forming the side chain, or in the form of one of the possible diastereoisomers and enantiomers, and their salts with pharmaceutically acceptable acids or bases; they are useful as immunoregulators and in cardiovascular and inflammatory treatment, especially in septic shock.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI932153A IT1271485B (en) | 1993-10-12 | 1993-10-12 | Retroinverted peptides having immunomodulating activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI932153A IT1271485B (en) | 1993-10-12 | 1993-10-12 | Retroinverted peptides having immunomodulating activity |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI932153A0 ITMI932153A0 (en) | 1993-10-12 |
ITMI932153A1 ITMI932153A1 (en) | 1995-04-12 |
IT1271485B true IT1271485B (en) | 1997-05-28 |
Family
ID=11367009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI932153A IT1271485B (en) | 1993-10-12 | 1993-10-12 | Retroinverted peptides having immunomodulating activity |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1271485B (en) |
-
1993
- 1993-10-12 IT ITMI932153A patent/IT1271485B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITMI932153A0 (en) | 1993-10-12 |
ITMI932153A1 (en) | 1995-04-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19960926 |