IT1271429B - New bile acid derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents

New bile acid derivatives, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IT1271429B
IT1271429B ITMI930420A ITMI930420A IT1271429B IT 1271429 B IT1271429 B IT 1271429B IT MI930420 A ITMI930420 A IT MI930420A IT MI930420 A ITMI930420 A IT MI930420A IT 1271429 B IT1271429 B IT 1271429B
Authority
IT
Italy
Prior art keywords
alpha
preparation
pharmaceutical compositions
compositions containing
acid derivatives
Prior art date
Application number
ITMI930420A
Other languages
Italian (it)
Inventor
Massimo Parenti
Costa Edoardo Bozzo
Original Assignee
Prodotti Chimici Alimentari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prodotti Chimici Alimentari filed Critical Prodotti Chimici Alimentari
Priority to ITMI930420A priority Critical patent/IT1271429B/en
Publication of ITMI930420A0 publication Critical patent/ITMI930420A0/en
Priority to KR1019940004161A priority patent/KR940021065A/en
Publication of ITMI930420A1 publication Critical patent/ITMI930420A1/en
Application granted granted Critical
Publication of IT1271429B publication Critical patent/IT1271429B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The new amides of bile acids having the general formula <IMAGE> where A1 can be alpha-OH or β-OH where A2 may be H or alpha-OH or β-OH where A3 may be H or alpha-OH or β-OH where A4 may be H or alpha-OH or β-OH R represents H, an alkali metal or alkaline earth metal or an organic base or a basic amino acid, its organic salts with pharmaceutically active bases, with amino acids (lysine or arginine) or with inorganic ions (Na, Ca, etc.) and R1 represents straight or branched C1-C5 alkyls. These have chemical, metabolic and pharmacological properties which render them potentially useful in pathological conditions such as gallstones, biliary dyspepsia, lipid exchange diseases with a cytoprotective effect on the cell membranes.
ITMI930420A 1993-03-05 1993-03-05 New bile acid derivatives, process for their preparation and pharmaceutical compositions containing them IT1271429B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ITMI930420A IT1271429B (en) 1993-03-05 1993-03-05 New bile acid derivatives, process for their preparation and pharmaceutical compositions containing them
KR1019940004161A KR940021065A (en) 1993-03-05 1994-03-04 Novel derivatives of bile acids and processes for the preparation of pharmaceutical components comprising the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI930420A IT1271429B (en) 1993-03-05 1993-03-05 New bile acid derivatives, process for their preparation and pharmaceutical compositions containing them

Publications (3)

Publication Number Publication Date
ITMI930420A0 ITMI930420A0 (en) 1993-03-05
ITMI930420A1 ITMI930420A1 (en) 1994-09-05
IT1271429B true IT1271429B (en) 1997-05-28

Family

ID=11365244

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI930420A IT1271429B (en) 1993-03-05 1993-03-05 New bile acid derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (2)

Country Link
KR (1) KR940021065A (en)
IT (1) IT1271429B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023008891A1 (en) 2021-07-26 2023-02-02 (주)샤페론 Novel compound that inhibits tnf-a generation and inflammasome activity and preparation method therefor

Also Published As

Publication number Publication date
ITMI930420A0 (en) 1993-03-05
KR940021065A (en) 1994-10-17
ITMI930420A1 (en) 1994-09-05

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970327