IT1265777B1 - Chitosanes having imidazole groups, uses and methods of production - Google Patents
Chitosanes having imidazole groups, uses and methods of productionInfo
- Publication number
- IT1265777B1 IT1265777B1 IT92AN000033A ITAN920033A IT1265777B1 IT 1265777 B1 IT1265777 B1 IT 1265777B1 IT 92AN000033 A IT92AN000033 A IT 92AN000033A IT AN920033 A ITAN920033 A IT AN920033A IT 1265777 B1 IT1265777 B1 IT 1265777B1
- Authority
- IT
- Italy
- Prior art keywords
- imidazole
- chitosanes
- properties
- reaction
- capacity
- Prior art date
Links
- 229920001661 Chitosan Polymers 0.000 title abstract 3
- 125000002883 imidazolyl group Chemical group 0.000 title abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 6
- 239000000463 material Substances 0.000 abstract 2
- 229920003023 plastic Polymers 0.000 abstract 2
- 239000004033 plastic Substances 0.000 abstract 2
- BBOOMRFBUGNJOS-UHFFFAOYSA-N 3-(1h-imidazol-2-yl)-2-oxopropanoic acid Chemical compound OC(=O)C(=O)CC1=NC=CN1 BBOOMRFBUGNJOS-UHFFFAOYSA-N 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 229920001222 biopolymer Polymers 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
The imidazole group is inserted into the chitosanes according to this invention through reaction of the latter with imidazole carboxyaldehyde or with urocyanic acid, or with other reagents such as imidazole pyruvic acid. The product of the imidazole carboxyaldehyde reaction, known as imidazolyl chitosane, has the properties of a highly cationic, water-soluble, chelating, antimicrobial and film-generating polysaccharide. These properties, together with its optimum stability during storage, its predisposition to cross-linking on the surfaces of plastics material and its capacity for unequivocal identification through N-NMR make it a useful biopolymer for making plastics materials for medical use biocompatible and for preventing infections during their use. The bactericidal capacity of this class of chitosanes makes it suitable for all in vivo and in vitro applications of other kinds such as medication for wounds and burns, the prevention of tissue adhesiveness, cell cultures and cosmetic formulations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT92AN000033A IT1265777B1 (en) | 1992-09-28 | 1992-09-28 | Chitosanes having imidazole groups, uses and methods of production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT92AN000033A IT1265777B1 (en) | 1992-09-28 | 1992-09-28 | Chitosanes having imidazole groups, uses and methods of production |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITAN920033A0 ITAN920033A0 (en) | 1992-09-28 |
| ITAN920033A1 ITAN920033A1 (en) | 1994-03-29 |
| IT1265777B1 true IT1265777B1 (en) | 1996-12-02 |
Family
ID=11333628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT92AN000033A IT1265777B1 (en) | 1992-09-28 | 1992-09-28 | Chitosanes having imidazole groups, uses and methods of production |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1265777B1 (en) |
-
1992
- 1992-09-28 IT IT92AN000033A patent/IT1265777B1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITAN920033A0 (en) | 1992-09-28 |
| ITAN920033A1 (en) | 1994-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |