IT1265209B1 - DIPHENYLIMIDAZOLES USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ARTERIOSCLEROSIS AND CORONARY DISEASES PROCEDURE FOR THEIR - Google Patents
DIPHENYLIMIDAZOLES USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ARTERIOSCLEROSIS AND CORONARY DISEASES PROCEDURE FOR THEIRInfo
- Publication number
- IT1265209B1 IT1265209B1 IT93MI002468A ITMI932468A IT1265209B1 IT 1265209 B1 IT1265209 B1 IT 1265209B1 IT 93MI002468 A IT93MI002468 A IT 93MI002468A IT MI932468 A ITMI932468 A IT MI932468A IT 1265209 B1 IT1265209 B1 IT 1265209B1
- Authority
- IT
- Italy
- Prior art keywords
- diphenylimidazoles
- dyslipidemia
- arteriosclerosis
- procedure
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
I difenilimidazoli aventi formula di struttura generale (I) (FORMULA I) dove Z rappresenta 4,5-difenilimidazol-2-tio, 2-piridossi; 3,5-diterbutil,4-idrossi-fenil-1-tio; imidazol 1,2-b pirazol-1-ile anche sostituito, 2,3-diidro-1H-imidazo 1,2-b pirazol-1-ile, oppure (FORMULA II) tiazolidin-2,4-dione-5-ile,hanno attività ACAT inibitoria.Sono anche descritti i metodi per la loro preparazione.The diphenylimidazoles having formula of general structure (I) (FORMULA I) where Z represents 4,5-diphenylimidazol-2-thio, 2-pyridoxy; 3,5-diterbutyl, 4-hydroxy-phenyl-1-thio; imidazol 1,2-b pyrazol-1-ile also substituted, 2,3-dihydro-1H-imidazo 1,2-b pyrazol-1-ile, or (FORMULA II) thiazolidin-2,4-dione-5-ile , have inhibitory ACAT activity.The methods for their preparation are also described.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93MI002468A IT1265209B1 (en) | 1993-11-22 | 1993-11-22 | DIPHENYLIMIDAZOLES USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ARTERIOSCLEROSIS AND CORONARY DISEASES PROCEDURE FOR THEIR |
EP94931591A EP0680472A1 (en) | 1993-11-22 | 1994-11-09 | 4,5-diphenylimidazole derivatives, their preparation and their use as acyl coenzyme a: cholesterol-0-acyl-transferase (acat) inhibitor |
CA002154475A CA2154475A1 (en) | 1993-11-22 | 1994-11-09 | 4,5-diphenylimidazole derivatives, their preparation and their use as acyl coenzyme a: cholesterol-0-acyl-transferase (acat) inhibitor |
AU80618/94A AU8061894A (en) | 1993-11-22 | 1994-11-09 | 4,5-diphenylimidazole derivatives, their preparation and their use as acyl coenzyme A: cholesterol-0-acyl-transferase (ACAT) inhibitor |
PCT/EP1994/003684 WO1995014673A1 (en) | 1993-11-22 | 1994-11-09 | 4,5-diphenylimidazole derivatives, their preparation and their use as acyl coenzyme a: cholesterol-0-acyl-transferase (acat) inhibitor |
JP7514784A JPH08506122A (en) | 1993-11-22 | 1994-11-09 | Novel diphenylimidazole effective for treatment of dyslipidemia, atherosclerosis and heart disease, method for producing the same, and pharmaceutical composition containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93MI002468A IT1265209B1 (en) | 1993-11-22 | 1993-11-22 | DIPHENYLIMIDAZOLES USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ARTERIOSCLEROSIS AND CORONARY DISEASES PROCEDURE FOR THEIR |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI932468A0 ITMI932468A0 (en) | 1993-11-22 |
ITMI932468A1 ITMI932468A1 (en) | 1995-05-22 |
IT1265209B1 true IT1265209B1 (en) | 1996-10-31 |
Family
ID=11367238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT93MI002468A IT1265209B1 (en) | 1993-11-22 | 1993-11-22 | DIPHENYLIMIDAZOLES USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ARTERIOSCLEROSIS AND CORONARY DISEASES PROCEDURE FOR THEIR |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0680472A1 (en) |
JP (1) | JPH08506122A (en) |
AU (1) | AU8061894A (en) |
CA (1) | CA2154475A1 (en) |
IT (1) | IT1265209B1 (en) |
WO (1) | WO1995014673A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1182400A (en) * | 1998-11-17 | 2000-06-05 | Fuji Photo Film Co., Ltd. | Heteroarylthio compounds and cancer remedies containing the same |
JPWO2004007464A1 (en) * | 2002-07-10 | 2005-11-10 | 住友製薬株式会社 | Imidazole derivatives |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4188397A (en) * | 1978-09-22 | 1980-02-12 | Smithkline Corporation | 2,2-Alkyldiylbis(thio)bis(imidazoles) |
US4716175A (en) * | 1987-02-24 | 1987-12-29 | Warner-Lambert Company | Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase |
IL96619A0 (en) * | 1989-12-11 | 1991-09-16 | Rhone Poulenc Sante | Imidazole derivatives,process for their preparation and pharmaceutical compositions containing them |
WO1991009030A1 (en) * | 1989-12-12 | 1991-06-27 | Rhone-Poulenc Sante | 2-substituted 4,5-diphenyl-imidazoles |
WO1991010662A1 (en) * | 1990-01-12 | 1991-07-25 | Rhone-Poulenc Rorer S.A. | 2-substituted 4,5-diphenyl-imidazoles |
GB9005966D0 (en) * | 1990-03-16 | 1990-05-09 | May & Baker Ltd | New compositions of matter |
PL296945A1 (en) * | 1990-07-03 | 1992-07-13 | Yamanouchi Pharma Co Ltd | |
IT1248528B (en) * | 1991-06-21 | 1995-01-19 | Pierrel Spa | AROMATIC ETHER AND THIOETHER (HETER) DERIVATIVES HAVING ANTI-HYPERLIPIDEMIC ACTIVITY, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
GB9115190D0 (en) * | 1991-07-12 | 1991-08-28 | Rhone Poulenc Rorer Ltd | New compositions of matter |
CA2085844A1 (en) * | 1991-12-27 | 1993-06-28 | Nobuyuki Hamanaka | Fused benzeneoxyacetic acid derivatives |
US5364875A (en) * | 1992-05-11 | 1994-11-15 | The Du Pont Merck Pharmaceutical Company | Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis |
US5310748A (en) * | 1992-05-11 | 1994-05-10 | The Du Pont Merck Pharmaceutical Company | Imidazoles for the treatment of atherosclerosis |
-
1993
- 1993-11-22 IT IT93MI002468A patent/IT1265209B1/en active IP Right Grant
-
1994
- 1994-11-09 WO PCT/EP1994/003684 patent/WO1995014673A1/en not_active Application Discontinuation
- 1994-11-09 CA CA002154475A patent/CA2154475A1/en not_active Abandoned
- 1994-11-09 JP JP7514784A patent/JPH08506122A/en active Pending
- 1994-11-09 AU AU80618/94A patent/AU8061894A/en not_active Abandoned
- 1994-11-09 EP EP94931591A patent/EP0680472A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
ITMI932468A1 (en) | 1995-05-22 |
ITMI932468A0 (en) | 1993-11-22 |
AU8061894A (en) | 1995-06-13 |
EP0680472A1 (en) | 1995-11-08 |
CA2154475A1 (en) | 1995-06-01 |
JPH08506122A (en) | 1996-07-02 |
WO1995014673A1 (en) | 1995-06-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2125233T3 (en) | TREATMENT OF HUMAN RETROVIRAL INFECTIONS WITH 2 ', 3'-DIDESOXYINOSINE. | |
NO882472D0 (en) | PROCEDURE FOR THE PREPARATION OF PEPTID DRILL ACID INHIBITORS FOR TRYP SIMILAR PROTASES. | |
IT1256450B (en) | NITRIC ESTERS WITH PHARMACOLOGICAL ACTIVITY AND PROCEDURE FOR THEIR PREPARATION | |
DE69333297D1 (en) | PRODUCTION OF STACKS OF CHIPS BY SEGMENTING LARGER STACKS | |
NO944335D0 (en) | New mercaptoacetylamido-pyridazo [1,2Å pyridazine, pyrazolo [1,2Å pyridazine, pyridazole [1,2-aÅ [1,2Å diazepine and pyrazolo [1,2-aÅ [1,2Å diazepine derivatives useful as inhibitors of enkephalinase and ACE | |
ITRM940150A0 (en) | PROCEDURE FOR THE TREATMENT OF STRONGLY COLORED WASTEWATER. | |
MX9205046A (en) | 1H-IMIDAZO- (4,5-C) QUINOLIN-4-AMINAS 1-SUBSTITUTED | |
IT8722220A0 (en) | METHOD FOR THE PREPARATION OF TITANIUM SILICALITES. | |
FI843001A0 (en) | PYRROLO (1,2-A) IMIDAZOLE-OCH IMIDATZO (1,2-A) PYRIDINIMMUNOMODULATORER. | |
ES2157992T3 (en) | ALCOXI-ALQUIL-CARBAMATOS DE IMIDAZO (1,2-A) PIRIDINES. | |
NO885459D0 (en) | MODULAR BUILDING CONSTRUCTION AND PREFABRICATED COMPONENTS FOR SAME, AND PROCEDURE FOR CONSTRUCTION OF BUILDING BASED ON SUCH COMPONENTS. | |
IT1256623B (en) | TACHYCHININ ANTAGONISTS, PROCEDURE FOR THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULATIONS | |
IT1265209B1 (en) | DIPHENYLIMIDAZOLES USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ARTERIOSCLEROSIS AND CORONARY DISEASES PROCEDURE FOR THEIR | |
EP0262318A3 (en) | Renin-inhibiting amino acid derivatives | |
NO880851D0 (en) | PROCEDURE FOR THE PREPARATION OF NEW RENIN INHIBITORS. | |
NO991734L (en) | Pyrazolinones for the treatment of potency disorders | |
ITRM930502A0 (en) | PROCEDURE FOR THE PRODUCTION OF R AMINOCARNITINE AND S AMINOCARNITINE. | |
ATE91689T1 (en) | GEMINAL BISPHOSPHONE ACIDS AND THEIR DERIVATIVES AS ANTIARTHRITIC AGENTS. | |
FI883247A (en) | 7- / 1H-PYRROOL-3-YL / SUBSTITUTE 3,5-DIHYDROXIHEPT-6-ENSYROR, 7- / 1H-PYRROL-3-YL / SUSBTITUERADE 3,5-DIHYDROXIHEPTANSYROR, MOTOR VARANT SALTER FOERFARANDE FOER FRAMSTAELLNING AV DESSA, DERAS ANVAENDNING SOM LAEKEMEDEL, PHARMACEUTICAL PREPARAT OCH MELLANPRODUKTER. | |
IT8820027A0 (en) | AQUEOUS EMULSIONS OF POLYISOCYANATES AND PROCEDURE FOR THEIR PREPARATION. | |
ITTO930477A1 (en) | PROCEDURE FOR THE CREATION OF DIAPHRAGMS, BASES AND MONOLITHIC SQUARES AND RELATED EQUIPMENT. | |
IT8721683A0 (en) | PROCEDURE FOR THE RAPID REHYDRATION OF LEGUMES AND THE SIMILAR, AS WELL AS EQUIPMENT FOR THE RAPID AND CONTINUOUS REHYDRATION OF LEGUMES AND THE SIMILAR. | |
IT1142938B (en) | PROCEDURE FOR THE PRODUCTION OF IMIDAZO (4,5-B) -PYRIDIN AND IMIDAZO (4,5-B) -PYRIMIDINE | |
ITRM930260A0 (en) | PROCEDURE FOR THE PRODUCTION OF PERFLUOROETHERCARBOXYLIC ACIDS. | |
IT1237501B (en) | POLYTHIOCARBONATES AND PROCEDURE FOR THEIR PREPARATION. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |