IT1264673B1 - Optically active derivatives of proline, their preparation and their use as catalysts for aldol and similar biostereo-selective and enantiomer-selective condensations - Google Patents
Optically active derivatives of proline, their preparation and their use as catalysts for aldol and similar biostereo-selective and enantiomer-selective condensationsInfo
- Publication number
- IT1264673B1 IT1264673B1 IT93MI001459A ITMI931459A IT1264673B1 IT 1264673 B1 IT1264673 B1 IT 1264673B1 IT 93MI001459 A IT93MI001459 A IT 93MI001459A IT MI931459 A ITMI931459 A IT MI931459A IT 1264673 B1 IT1264673 B1 IT 1264673B1
- Authority
- IT
- Italy
- Prior art keywords
- selective
- proline
- condensations
- aldol
- enantiomer
- Prior art date
Links
- HSJKGGMUJITCBW-UHFFFAOYSA-N 3-hydroxybutanal Chemical compound CC(O)CC=O HSJKGGMUJITCBW-UHFFFAOYSA-N 0.000 title abstract 4
- 239000003054 catalyst Substances 0.000 title abstract 2
- 238000009833 condensation Methods 0.000 title abstract 2
- 230000005494 condensation Effects 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 125000001500 prolyl group Chemical class [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 title 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000686 lactone group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003148 prolines Chemical class 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Landscapes
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Optically active derivatives of proline of general formula I <IMAGE> are described, there derivatives having a configuration at the asymmetric carbonium atom indicated by an asterisk which is the same as that of the asymmetrical carbonium atom of the originating proline, and in which: R is selected from H, OH; R1 is selected from H, straight or branched C1-C10 alkyl, C1-C10 aryl alkyl, (CH2)1 COOH where 1 is a whole number of between 1 and 5, COOR2 where R2 is selected from benzyl, t-butyl, R4 is H and R5 is COOH, or R4 and R5 together form the lactone group: <IMAGE> n = 0 or a whole number selected from between 1 and 3, a process for their preparation, and their use as catalysts for aldol or similar diastereo-selective or enantiomer- selective condensations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT93MI001459A IT1264673B1 (en) | 1993-07-06 | 1993-07-06 | Optically active derivatives of proline, their preparation and their use as catalysts for aldol and similar biostereo-selective and enantiomer-selective condensations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT93MI001459A IT1264673B1 (en) | 1993-07-06 | 1993-07-06 | Optically active derivatives of proline, their preparation and their use as catalysts for aldol and similar biostereo-selective and enantiomer-selective condensations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI931459A0 ITMI931459A0 (en) | 1993-07-06 |
| ITMI931459A1 ITMI931459A1 (en) | 1995-01-06 |
| IT1264673B1 true IT1264673B1 (en) | 1996-10-04 |
Family
ID=11366541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT93MI001459A IT1264673B1 (en) | 1993-07-06 | 1993-07-06 | Optically active derivatives of proline, their preparation and their use as catalysts for aldol and similar biostereo-selective and enantiomer-selective condensations |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1264673B1 (en) |
-
1993
- 1993-07-06 IT IT93MI001459A patent/IT1264673B1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI931459A1 (en) | 1995-01-06 |
| ITMI931459A0 (en) | 1993-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970730 |