IT1263957B - THERAPEUTIC USE OF PYROLIDON CARBOXYLATE OF PYRIDOXY - Google Patents
THERAPEUTIC USE OF PYROLIDON CARBOXYLATE OF PYRIDOXYInfo
- Publication number
- IT1263957B IT1263957B ITMI930341A ITMI930341A IT1263957B IT 1263957 B IT1263957 B IT 1263957B IT MI930341 A ITMI930341 A IT MI930341A IT MI930341 A ITMI930341 A IT MI930341A IT 1263957 B IT1263957 B IT 1263957B
- Authority
- IT
- Italy
- Prior art keywords
- carboxylate
- pyrolidon
- pyridoxy
- therapeutic use
- fatty acids
- Prior art date
Links
- -1 PYRIDOXY Chemical class 0.000 title 1
- 150000007942 carboxylates Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 235000021588 free fatty acids Nutrition 0.000 abstract 2
- MQNRNEABTODWHK-UHFFFAOYSA-N [5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methyl 2-oxopyrrolidine-1-carboxylate Chemical compound OCC1=C(O)C(C)=NC=C1COC(=O)N1C(=O)CCC1 MQNRNEABTODWHK-UHFFFAOYSA-N 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 230000004075 alteration Effects 0.000 abstract 1
- 210000001557 animal structure Anatomy 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000009088 enzymatic function Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
Abstract
La somministrazione di pirrolidon carbossilato di piridossina consente di inibire la formazione di esteri etilici degli acidi grassi liberi ed il loro accumulo negli organi animali, nonché di compensare alterazioni delle funzioni enzimatiche connesse con gli acidi grassi liberi ed i loro esteri.The administration of pyridoxine pyrrolidon carboxylate allows to inhibit the formation of ethyl esters of free fatty acids and their accumulation in animal organs, as well as to compensate for alterations in the enzymatic functions associated with free fatty acids and their esters.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI930341A IT1263957B (en) | 1993-02-23 | 1993-02-23 | THERAPEUTIC USE OF PYROLIDON CARBOXYLATE OF PYRIDOXY |
TW082104060A TW230749B (en) | 1993-02-23 | 1993-05-22 | |
PCT/EP1994/000518 WO1994018965A1 (en) | 1993-02-23 | 1994-02-19 | Therapeutic use of pyridoxine pyrrolidone carboxylate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI930341A IT1263957B (en) | 1993-02-23 | 1993-02-23 | THERAPEUTIC USE OF PYROLIDON CARBOXYLATE OF PYRIDOXY |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI930341A0 ITMI930341A0 (en) | 1993-02-23 |
ITMI930341A1 ITMI930341A1 (en) | 1994-08-23 |
IT1263957B true IT1263957B (en) | 1996-09-05 |
Family
ID=11365120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI930341A IT1263957B (en) | 1993-02-23 | 1993-02-23 | THERAPEUTIC USE OF PYROLIDON CARBOXYLATE OF PYRIDOXY |
Country Status (3)
Country | Link |
---|---|
IT (1) | IT1263957B (en) |
TW (1) | TW230749B (en) |
WO (1) | WO1994018965A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6043259A (en) * | 1998-07-09 | 2000-03-28 | Medicure Inc. | Treatment of cardiovascular and related pathologies |
JP2002539127A (en) | 1999-03-08 | 2002-11-19 | メディキュア インコーポレーテッド | Pyridoxal analogs for vitamin B-6 disorders |
US6489345B1 (en) | 1999-07-13 | 2002-12-03 | Medicure, Inc. | Treatment of diabetes and related pathologies |
JP2003528146A (en) | 2000-03-28 | 2003-09-24 | メディキュア インターナショナル インコーポレイテッド | Treatment of cerebrovascular disease |
IL187159A0 (en) | 2007-07-03 | 2009-02-11 | Gur Megiddo | Use of metadoxine in relief of alcohol intoxication |
AU2007362353A1 (en) * | 2007-12-12 | 2009-06-18 | Northern Innovations And Formulations Corp. | Preparations containing pyridoxine and alpha-hydroxyisocaproic acid (HICA) |
EP2323735A1 (en) | 2008-07-29 | 2011-05-25 | Alcobra Ltd. | Substituted pyridoxine-lactam carboxylate salts |
WO2010150261A1 (en) | 2009-06-25 | 2010-12-29 | Alcobra Ltd. | A method for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2485372B1 (en) * | 1980-06-30 | 1985-08-09 | Baldacci Lab Spa | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ACUTE ALCOHOLIC POISONING BASED ON PYRIDOXIN 5-OXO-2-PYRROLIDONE CARBOXYLATE AND PROCESS FOR PREPARING THE SAME |
-
1993
- 1993-02-23 IT ITMI930341A patent/IT1263957B/en active IP Right Grant
- 1993-05-22 TW TW082104060A patent/TW230749B/zh not_active IP Right Cessation
-
1994
- 1994-02-19 WO PCT/EP1994/000518 patent/WO1994018965A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
ITMI930341A0 (en) | 1993-02-23 |
TW230749B (en) | 1994-09-21 |
WO1994018965A1 (en) | 1994-09-01 |
ITMI930341A1 (en) | 1994-08-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970227 |