IT1261958B - 2-(substituted imino)-thiazolidines and process for their preparation - Google Patents
2-(substituted imino)-thiazolidines and process for their preparationInfo
- Publication number
- IT1261958B IT1261958B ITMI921181A ITMI921181A IT1261958B IT 1261958 B IT1261958 B IT 1261958B IT MI921181 A ITMI921181 A IT MI921181A IT MI921181 A ITMI921181 A IT MI921181A IT 1261958 B IT1261958 B IT 1261958B
- Authority
- IT
- Italy
- Prior art keywords
- substituted
- alkyl
- imine
- thiazolidines
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 2-(substituted imino)-thiazolidines Chemical class 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 239000005864 Sulphur Substances 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000002466 imines Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003257 anti-anginal effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000000879 imine group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to original 2-(imine substituted)- thiazolidines, a process for their preparation, pharmaceutical compositions containing them, use of the said 2-(imine substituted)-thiazolidines for the treatment of diseases, for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The original 2-(imine substituted)-thiazolidine derivatives provided by this invention have the general formula I <IMAGE> in which R<1> and R2> each represent halogen, nitro, C1-4 alkoxy or C1-4 alkyl, in which the latter may optionally have one or more halogen substituents, R<3> and R4> are hydrogen or C1-4 alkyl, Z indicates oxygen, sulphur or imine, which latter is substituted by a C1-6 alkyl group or a C1-6 alkenyl group, R<5> is hydrogen, C1-4 alkyl, C1- 4 alkylthio or a group having the formula -NHR in which R represents C1-6 alkyl, aryl, aralkyl or C1-6 alkenyl optionally bearing a halogen or C1-4 alkylamino substituent, or Z and R<5> together are a trivalent nitrogen atom, such that if Z indicates a substituted imine group R<5> is C1-4 alkylthio, and if R<5> is C1-4- alkylthio Z is a substituted imine, and further that if Z is sulphur, R<5> is not hydrogen or C1-4 alkyl, and have useful antianginal and analgesic properties.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI921181A IT1261958B (en) | 1992-05-15 | 1992-05-15 | 2-(substituted imino)-thiazolidines and process for their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI921181A IT1261958B (en) | 1992-05-15 | 1992-05-15 | 2-(substituted imino)-thiazolidines and process for their preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI921181A0 ITMI921181A0 (en) | 1992-05-15 |
| ITMI921181A1 ITMI921181A1 (en) | 1993-11-16 |
| IT1261958B true IT1261958B (en) | 1996-06-11 |
Family
ID=11363305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI921181A IT1261958B (en) | 1992-05-15 | 1992-05-15 | 2-(substituted imino)-thiazolidines and process for their preparation |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1261958B (en) |
-
1992
- 1992-05-15 IT ITMI921181A patent/IT1261958B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI921181A0 (en) | 1992-05-15 |
| ITMI921181A1 (en) | 1993-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950531 |