IT1258310B - PHARMACEUTICAL COMPOSITIONS INCLUDING MONOSIAL-GANGLIOSIDIC DERIVATIVES FOR THE TREATMENT OF DAMAGE TO THE SPINAL CORD. - Google Patents
PHARMACEUTICAL COMPOSITIONS INCLUDING MONOSIAL-GANGLIOSIDIC DERIVATIVES FOR THE TREATMENT OF DAMAGE TO THE SPINAL CORD.Info
- Publication number
- IT1258310B IT1258310B ITMI920878A ITMI920878A IT1258310B IT 1258310 B IT1258310 B IT 1258310B IT MI920878 A ITMI920878 A IT MI920878A IT MI920878 A ITMI920878 A IT MI920878A IT 1258310 B IT1258310 B IT 1258310B
- Authority
- IT
- Italy
- Prior art keywords
- derivatives
- treatment
- pharmaceutical compositions
- spinal cord
- gangliosidic
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 210000000278 spinal cord Anatomy 0.000 title abstract 2
- 101100322805 Arabidopsis thaliana AHL15 gene Proteins 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- QPJBWNIQKHGLAU-IQZHVAEDSA-N ganglioside GM1 Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@H](NC(=O)CCCCCCCCCCCCCCCCC)[C@H](O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 QPJBWNIQKHGLAU-IQZHVAEDSA-N 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Composizioni farmaceutiche comprendenti derivati monosialogangliosidici atte al trattamento del danno al midollo spinale provocato da eventi ipossi-ischemici o traumatici, in cui detti derivati sono scelti nel gruppo costituito dall'estere interno del monosialoganglioside GM1 (AGF2) e dall'estere metilico (AGF 4) dello stesso monosialoganglioside.Pharmaceutical compositions comprising monosialoganglioside derivatives suitable for the treatment of spinal cord damage caused by hypoxischemic or traumatic events, wherein said derivatives are selected from the group consisting of the internal ester of monosialoganglioside GM1 (AGF2) and methyl ester (AGF 4) of the same monosialoganglioside.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI920878A IT1258310B (en) | 1992-04-10 | 1992-04-10 | PHARMACEUTICAL COMPOSITIONS INCLUDING MONOSIAL-GANGLIOSIDIC DERIVATIVES FOR THE TREATMENT OF DAMAGE TO THE SPINAL CORD. |
| EP93911460A EP0633782A1 (en) | 1992-04-10 | 1993-04-13 | Pharmaceutical compositions containing monosialoganglioside derivatives suitable for the treatment of spinal cord injury |
| PCT/EP1993/000894 WO1993020824A1 (en) | 1992-04-10 | 1993-04-13 | Pharmaceutical compositions containing monosialoganglioside derivatives suitable for the treatment of spinal cord injury |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI920878A IT1258310B (en) | 1992-04-10 | 1992-04-10 | PHARMACEUTICAL COMPOSITIONS INCLUDING MONOSIAL-GANGLIOSIDIC DERIVATIVES FOR THE TREATMENT OF DAMAGE TO THE SPINAL CORD. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI920878A0 ITMI920878A0 (en) | 1992-04-10 |
| ITMI920878A1 ITMI920878A1 (en) | 1993-10-10 |
| IT1258310B true IT1258310B (en) | 1996-02-22 |
Family
ID=11362885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI920878A IT1258310B (en) | 1992-04-10 | 1992-04-10 | PHARMACEUTICAL COMPOSITIONS INCLUDING MONOSIAL-GANGLIOSIDIC DERIVATIVES FOR THE TREATMENT OF DAMAGE TO THE SPINAL CORD. |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0633782A1 (en) |
| IT (1) | IT1258310B (en) |
| WO (1) | WO1993020824A1 (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4476119A (en) * | 1981-08-04 | 1984-10-09 | Fidia S.P.A. | Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions |
| IT1254706B (en) * | 1991-12-23 | 1995-10-09 | Fidia Spa | THERAPEUTIC USE OF GANGLIOSIDE GM1 IN THE TREATMENT OF DAMAGE TO THE SPINAL CORD |
-
1992
- 1992-04-10 IT ITMI920878A patent/IT1258310B/en active IP Right Grant
-
1993
- 1993-04-13 EP EP93911460A patent/EP0633782A1/en not_active Withdrawn
- 1993-04-13 WO PCT/EP1993/000894 patent/WO1993020824A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI920878A1 (en) | 1993-10-10 |
| EP0633782A1 (en) | 1995-01-18 |
| WO1993020824A1 (en) | 1993-10-28 |
| ITMI920878A0 (en) | 1992-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970429 |