IT1256250B - SYNTHETIC PEPTIDES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE FOR THE ADMINISTRATION OF DRUGS THROUGH THE HEMATO-ENCEPHALIC BARRIER AND THE RETINA. - Google Patents
SYNTHETIC PEPTIDES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE FOR THE ADMINISTRATION OF DRUGS THROUGH THE HEMATO-ENCEPHALIC BARRIER AND THE RETINA.Info
- Publication number
- IT1256250B IT1256250B ITMI922969A ITMI922969A IT1256250B IT 1256250 B IT1256250 B IT 1256250B IT MI922969 A ITMI922969 A IT MI922969A IT MI922969 A ITMI922969 A IT MI922969A IT 1256250 B IT1256250 B IT 1256250B
- Authority
- IT
- Italy
- Prior art keywords
- retina
- drugs
- administration
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- 210000001525 retina Anatomy 0.000 title abstract 3
- 210000001218 blood-brain barrier Anatomy 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102100025227 Calcium/calmodulin-dependent protein kinase type II subunit gamma Human genes 0.000 abstract 1
- 101100287682 Homo sapiens CAMK2G gene Proteins 0.000 abstract 1
- 230000008499 blood brain barrier function Effects 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000035699 permeability Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Vengono descritti nuovi peptidi sintetici aventi la seguente sequenza agenti su una proteina microvascolare CAMK-II determinanti l'aumento di permeabilità della barriera emato-encefalica e utilizzabili nel trasporto di farmaci nel cervello e nella retina. (DESCRIZIONE) viene descritto inoltre il processo per la loro preparazione, le composizioni farmaceutiche che li contengono e il loro impiego per la somministrazione di farmaci a livello del sistema nervoso centrale e della retina.New synthetic peptides are described having the following sequence acting on a CAMK-II microvascular protein determining the increase in permeability of the blood-brain barrier and usable in the transport of drugs in the brain and retina. (DESCRIPTION) the process for their preparation, the pharmaceutical compositions containing them and their use for the administration of drugs at the level of the central nervous system and of the retina are also described.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI922969A IT1256250B (en) | 1992-12-24 | 1992-12-24 | SYNTHETIC PEPTIDES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE FOR THE ADMINISTRATION OF DRUGS THROUGH THE HEMATO-ENCEPHALIC BARRIER AND THE RETINA. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI922969A IT1256250B (en) | 1992-12-24 | 1992-12-24 | SYNTHETIC PEPTIDES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE FOR THE ADMINISTRATION OF DRUGS THROUGH THE HEMATO-ENCEPHALIC BARRIER AND THE RETINA. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI922969A0 ITMI922969A0 (en) | 1992-12-24 |
| ITMI922969A1 ITMI922969A1 (en) | 1994-06-24 |
| IT1256250B true IT1256250B (en) | 1995-11-29 |
Family
ID=11364543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI922969A IT1256250B (en) | 1992-12-24 | 1992-12-24 | SYNTHETIC PEPTIDES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE FOR THE ADMINISTRATION OF DRUGS THROUGH THE HEMATO-ENCEPHALIC BARRIER AND THE RETINA. |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1256250B (en) |
-
1992
- 1992-12-24 IT ITMI922969A patent/IT1256250B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI922969A1 (en) | 1994-06-24 |
| ITMI922969A0 (en) | 1992-12-24 |
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| 0001 | Granted |