IT1255026B - Oligonucleotidi antisenso e analoghi atti alla inibizione della biosintesi dell'enzima idrossi-metil-glutaril-coenzima a reduttasi - Google Patents
Oligonucleotidi antisenso e analoghi atti alla inibizione della biosintesi dell'enzima idrossi-metil-glutaril-coenzima a reduttasiInfo
- Publication number
- IT1255026B IT1255026B ITMI921112A ITMI921112A IT1255026B IT 1255026 B IT1255026 B IT 1255026B IT MI921112 A ITMI921112 A IT MI921112A IT MI921112 A ITMI921112 A IT MI921112A IT 1255026 B IT1255026 B IT 1255026B
- Authority
- IT
- Italy
- Prior art keywords
- coenzyme
- reductase
- biosynthesis
- inhibiting
- antisense oligonucleotides
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 3
- 108090000790 Enzymes Proteins 0.000 title abstract 3
- CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 title abstract 2
- 108020000948 Antisense Oligonucleotides Proteins 0.000 title abstract 2
- 239000000074 antisense oligonucleotide Substances 0.000 title abstract 2
- 238000012230 antisense oligonucleotides Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 206010021024 Hypolipidaemia Diseases 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 230000001173 tumoral effect Effects 0.000 abstract 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invenzione si riferisce a oligonucleotidi antisenso e loro analoghi in grado di inibire la biosintesi dell'enzima idrossi-metil-glutaril-coenzima A reduttasi, scelti fra gli oligonucleotidi complementari alla porzione 5' non tradotta, alla prima porzione tradotta, alla porzione comune tradotta e non tradotta ed alla regione 3' dell'mRNA di detto enzima.Gli oligonucleotidi e analoghi dell'invenzione possono essere utilizzati per il trattamento delle varie forme d'iperlipemia, dell'aterosclerosi e delle forme tumorali associate ad iperlipemia nonché per diagnosi e per ricerca.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI921112A IT1255026B (it) | 1992-05-08 | 1992-05-08 | Oligonucleotidi antisenso e analoghi atti alla inibizione della biosintesi dell'enzima idrossi-metil-glutaril-coenzima a reduttasi |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI921112A IT1255026B (it) | 1992-05-08 | 1992-05-08 | Oligonucleotidi antisenso e analoghi atti alla inibizione della biosintesi dell'enzima idrossi-metil-glutaril-coenzima a reduttasi |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI921112A0 ITMI921112A0 (it) | 1992-05-08 |
| ITMI921112A1 ITMI921112A1 (it) | 1993-11-08 |
| IT1255026B true IT1255026B (it) | 1995-10-13 |
Family
ID=11363252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI921112A IT1255026B (it) | 1992-05-08 | 1992-05-08 | Oligonucleotidi antisenso e analoghi atti alla inibizione della biosintesi dell'enzima idrossi-metil-glutaril-coenzima a reduttasi |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1255026B (it) |
-
1992
- 1992-05-08 IT ITMI921112A patent/IT1255026B/it active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI921112A0 (it) | 1992-05-08 |
| ITMI921112A1 (it) | 1993-11-08 |
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Legal Events
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|---|---|---|---|
| 0001 | Granted |