IT1254565B - Crystalline form of endo-2,3-dihydro-N-(8-methyl-8- azabicyclo-[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1- carboxamide hydrochloride - Google Patents

Crystalline form of endo-2,3-dihydro-N-(8-methyl-8- azabicyclo-[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1- carboxamide hydrochloride

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Publication number
IT1254565B
IT1254565B ITMI920723A ITMI920723A IT1254565B IT 1254565 B IT1254565 B IT 1254565B IT MI920723 A ITMI920723 A IT MI920723A IT MI920723 A ITMI920723 A IT MI920723A IT 1254565 B IT1254565 B IT 1254565B
Authority
IT
Italy
Prior art keywords
azabicyclo
endo
benzimidazole
dihydro
oxo
Prior art date
Application number
ITMI920723A
Other languages
Italian (it)
Inventor
Enzo Cereda
Enrica Dubini
Antoine Ezhaya
Grazia Maffione
Marco Turconi
Original Assignee
Boehringer Ingelheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Italia filed Critical Boehringer Ingelheim Italia
Publication of ITMI920723A0 publication Critical patent/ITMI920723A0/en
Priority to ITMI920723A priority Critical patent/IT1254565B/en
Priority to PH45858A priority patent/PH30413A/en
Priority to SG1996005867A priority patent/SG43225A1/en
Priority to EP93104564A priority patent/EP0567767B1/en
Priority to AT93104564T priority patent/ATE169016T1/en
Priority to CZ1993443A priority patent/CZ286590B6/en
Priority to DK93104564T priority patent/DK0567767T3/en
Priority to ES93104564T priority patent/ES2118846T3/en
Priority to DE69319955T priority patent/DE69319955T2/en
Priority to SK226-93A priority patent/SK280555B6/en
Priority to HRMI92A000723A priority patent/HRP930479B1/en
Priority to AU35413/93A priority patent/AU654082B2/en
Priority to TW082102205A priority patent/TW385310B/en
Priority to NZ247234A priority patent/NZ247234A/en
Priority to IL10514393A priority patent/IL105143A/en
Priority to FI931329A priority patent/FI113472B/en
Priority to PL93298263A priority patent/PL172890B1/en
Priority to JP06649293A priority patent/JP3279707B2/en
Priority to ZA932113A priority patent/ZA932113B/en
Priority to NO931112A priority patent/NO300975B1/en
Priority to RU93004710A priority patent/RU2125054C1/en
Priority to HU9300868A priority patent/HU211075B/en
Priority to CA002092510A priority patent/CA2092510C/en
Priority to MX9301668A priority patent/MX9301668A/en
Priority to SI9300150A priority patent/SI9300150B/en
Priority to UA93002686A priority patent/UA37179C2/en
Publication of ITMI920723A1 publication Critical patent/ITMI920723A1/en
Priority to US08/264,104 priority patent/US5468758A/en
Priority to HU95P/P00677P priority patent/HU211131A9/en
Application granted granted Critical
Publication of IT1254565B publication Critical patent/IT1254565B/en
Priority to BR1100564-5A priority patent/BR1100564A/en
Priority to HK98111436A priority patent/HK1010719A1/en
Priority to UY25939A priority patent/UY25939A1/en
Priority to UY25938A priority patent/UY25938A1/en

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Abstract

Crystalline monohydrate of endo-2,3-dihydro-N-(8-methyl-8- azabicyclo-[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1- carboxamide hydrochloride of formula <IMAGE> processes for its preparation and pharmaceutical formulations containing it. <IMAGE>
ITMI920723A 1992-03-26 1992-03-26 Crystalline form of endo-2,3-dihydro-N-(8-methyl-8- azabicyclo-[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1- carboxamide hydrochloride IT1254565B (en)

Priority Applications (32)

Application Number Priority Date Filing Date Title
ITMI920723A IT1254565B (en) 1992-03-26 1992-03-26 Crystalline form of endo-2,3-dihydro-N-(8-methyl-8- azabicyclo-[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1- carboxamide hydrochloride
PH45858A PH30413A (en) 1992-03-26 1993-03-11 Crystalline forms of endo-2,3-dihydro-n-(8-methyl)-8-azabicyclo-(3,2,1)oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamides
SG1996005867A SG43225A1 (en) 1992-03-26 1993-03-19 Crystalline forms of endo-2, 3-dihydro-n-(8-methyl -8-azabicyclo [3.2.1]oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamide hydrochloride monohydrate (see file for full title)
EP93104564A EP0567767B1 (en) 1992-03-26 1993-03-19 Crystalline forms of endo-2,3-dihydro-N-(8-methyl-8-azabicyclo (3.2.1)oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride monohydrate and of endo-3-ethyl-2,3-dihydro-N-(8-methyl-8-azabicyclo (3.2.1) oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride monohydrate as 5-HT antagonists
AT93104564T ATE169016T1 (en) 1992-03-26 1993-03-19 CRYSTALLINE FORMS OF ENDO-2,3-DIHYDRO-N-(8- METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL)-2-OXO-1H- BENZIMIDAZOLE-1-CARBOXAMIDE HYDROCHLORIDE MONOHYDRATE AND OF ENDO- 3-ETHYL-2,3-DIHYDRO-N-(8-METHYL-8- AZABICYCLO(3.2.1)OCT-3-YL)-2-OXO-1H-BENZIMIDAZO - 1-CARBOXAMIDE HYDROCHLORIDE MONOHYDRATE AS A 5-HT ANTAGONIST
CZ1993443A CZ286590B6 (en) 1992-03-26 1993-03-19 Crystalline monohydrate of endo-2,3-dihydro-N-(8-methyl-8-azabicyclo[3,2,1]oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride, process of its preparation and pharmaceutical preparation containing thereof
DK93104564T DK0567767T3 (en) 1992-03-26 1993-03-19 Crystalline forms of endo-2,3-dihydro-N- (8-methyl-8-azabicyclo [3.2.1] oct-3-yl) -2-oxo-1H-benzimidazole-1-carboxamide hydrocarbon
ES93104564T ES2118846T3 (en) 1992-03-26 1993-03-19 CRYSTALLINE FORMS OF ENDO-2,3-DIHYDRO-N- (8-METHYL-8-AZABICICLO (3.2.1) OCT-3-IL) -2-OXO-1H-BENZMIDAZOLE-1-CARBOXAMIDE AND HYDROCHLORIDE MONOHYDRATE ENDO-3-ETHYL-2,3-DIHYDRO-N- (8-METHYL-8-AZABICICLO (3.2.1) OCT-3-IL) -2-OXO-1H-BENCIMIDAZOL-1-CARBOXAMID HYDROCHLORIDE
DE69319955T DE69319955T2 (en) 1992-03-26 1993-03-19 Crystalline forms of endo-2,3-dihydro-N- (8-methyl-8-azabicyclo (3.2.1) oct-3-yl) -2-oxo-1H-benzimidazole-1-carboxamide hydrochloride monohydrate and of endo- 3-Ethyl-2,3-dihydro-N- (8-methyl-8-azabicyclo (3.2.1) oct-3-yl) -2-oxo-1H-benzimidazole-1-carboxamide hydrochloride monohydrate as a 5-HT antagonist
SK226-93A SK280555B6 (en) 1992-03-26 1993-03-22 Crystalline monohydrates of endo-2,3-dihydro-n-(8-methyl- -8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1h-benzimidazole-1- -carboxamide hydrochloride and of endo-3-ethyl-2,3- -dihydro-n-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1h- -benzimidazole-1-carboxamide hydrochloride, process for their preparation and pharmaceutical compositions containing them
HRMI92A000723A HRP930479B1 (en) 1992-03-26 1993-03-23 Crystalline forms of endo-2,3-dihydro-n-(8-methyl-8-azabicyclo (3.2.1)oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamide hydrochloride monohydrate and of endo-3-ethyl-2,3-dihydro-n-(8-methyl-8-azabicyclo (3.2.1)oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamide hydrochloride monohydrate
AU35413/93A AU654082B2 (en) 1992-03-26 1993-03-24 Crystalline monohydrates of azabicyclo-1H-benzimidozole-1- carboxamides, the preparation and use thereof
TW082102205A TW385310B (en) 1992-03-26 1993-03-24 Crystalline forms of endo-2,3-dihydro-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride monohydrate and of endo-3-ethyl-2,3-dihydro-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide
NZ247234A NZ247234A (en) 1992-03-26 1993-03-24 Crystalline monohydrates of 8-azabicyclo[3.2.1]octyl-1h-benzimidazole-1-carboxamide derivatives and pharmaceutical compositions
IL10514393A IL105143A (en) 1992-03-26 1993-03-24 Stable crystalline monohydrates of endo-2,3-dihydro-n-(8-methyl-8-azabicyclo [3.2.1] oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamides their preparation and pharmaceutical compositions containing them
PL93298263A PL172890B1 (en) 1992-03-26 1993-03-25 Crystalline forms of monohydrates of endo-2,3-dihydro-n-(8-methyl-8-azabicyclo [3.2.1] oct-3-ylo)-2-oxo-1h-benzimidazolo-1-carboxylamide, and endo-3-ethyl-2,3-dihydro-n-(8-methyl-8-azabicyclo [3.2.1] oct-3-ylo)-2-oxo-1h-benzimidazolo-1-carboxylamide hydrochlorides, methods of obtaining sames and pharmaceutical compositions containing them
FI931329A FI113472B (en) 1992-03-26 1993-03-25 The method provides pharmacologically active endo-2,3-dihydro-N- (8-methyl-8-azabicyclo [3.2.1] oct-3-yl) -2-oxo-1H-benzimidazole-1-carboxamide hydrochloride monohydrate and endo-3 crystalline forms of ethyl 2,3-dihydro-N- (8-methyl-8-azabicyclo [3.2.1] oct-3-yl) -2-oxo-1 H -benzimidazole-1-carboxamide hydrochloride monohydrate
JP06649293A JP3279707B2 (en) 1992-03-26 1993-03-25 Endo-2,3-dihydro-N- (8-methyl-8-azabicyclo [3.2.1] oct-3-yl) -2-oxo-1H-benzimidazole-1-carboxylic acid amide and endo-3 -Ethyl-2,3-dihydro-N- (8-methyl-8-azabicyclo [3.2.1] oct-3-yl) -2-oxo-1H-benzimidazole-1-carboxylic acid amide hydrochloride Crystal monohydrate of
ZA932113A ZA932113B (en) 1992-03-26 1993-03-25 Crystalline forms of benzimidazole carboxamide compounds
NO931112A NO300975B1 (en) 1992-03-26 1993-03-25 Crystalline forms of endo-2,3-dihydro-N- (8-methyl / hydrogen-8-azabicyclo [3.2.1] oct-3-yl) -2-oxo-1H-benzimidazole-1-carboxamide hydrochloride monohydrate
RU93004710A RU2125054C1 (en) 1992-03-26 1993-03-25 Crystalline monohydrates of endo-2,3-dihydro-n-(8-methyl-8- -azabicyclo-[3,2,1]-oct-3-yl)-2-oxo-1h-benzimidazole-1- -carboxamide and endo-3-ethyl-2,3-dihydro-n-(8-methyl-8-azabi- -cyclo-[3,2,1]-oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamide hydrochlorides, method of their synthesis and pharmaceutical composition
HU9300868A HU211075B (en) 1992-03-26 1993-03-25 Process for producing crystalline endo-2,3-dihydro-n-(8-methyl-8-aza-bicyclo-[3.2.1]okt-3-yl)-2-oxo-1h-benzimidazol-1-carboxamide-hydrochloride-monohydrate and endo-3-ethyl-2,3-dihydro-n-(8-methyl-8-azabicyclo[3.2.1]okt-3-yl)-2-oxo-1h-benzimidazol -1-carb
CA002092510A CA2092510C (en) 1992-03-26 1993-03-25 Crystalline forms of endo-2,3-dihydro-n-(8-methyl-8-azabicyclo-[3.2.1.]oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamide hydrochloride monohydrate and of endo-3 ethyl-2,3-dihydro-n-(8-methyl-8-azabicyclo[3.2.1.]oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamide hydrochloride monohydrate
MX9301668A MX9301668A (en) 1992-03-26 1993-03-25 CRYSTALLINE MONOHYDRATES OF– ENDO-2,3-DIHYDRO-N-(8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-IL)-2-OXO-1H-BENZIMIDAZOL-1-CARBOXAMIDE AND HYDROCHLORIDE ENDO-3-ETHYL-2,3-DIHYDRO-N-(8-METHYL-8-AZABICICYCLO(3.2.1)OCT-3-IL)-2-OXO-1H-BENZIMIDAZOL-1-CAR.
SI9300150A SI9300150B (en) 1992-03-26 1993-03-26 Endo-2,3-dihydro-n-(8-methyl-8-azabicyclo(3.2.1) okt-3-yl)-2-oxo-1h- benzimidazol-1-carboxamid hydrochlorid monohydrate and endo-3-ethyl- 2,3-dihydro-n-(8-methyl-8-azabicyclo-(3.2.1) okt-3-yl)-2-oxo-1h- benzimidazole-1-carboxamid hydrochlorid monohydrate christal forms
UA93002686A UA37179C2 (en) 1992-03-26 1993-06-08 Crystalline monohydrates of hydrochloride OF endo -2,3-dihydro-N-(8-methyl-8-azabicyclo [3.2.1 ]oct-3-yl) -2-oxo-1H-benzimidazole-1-carboxamide and endo-3-ethyl-2,3-dihydro-N-(8-methyl-8- azabicyclo [3.2.1]oct-3-yl)-2-oxo-1H- benzimidazole-1-carboxamide, method for the preparation thereof and pharmaceutical composition
US08/264,104 US5468758A (en) 1992-03-26 1994-06-22 Crystalline forms of endo-2,3-dihydro-N-(8-methyl)-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamides
HU95P/P00677P HU211131A9 (en) 1992-03-26 1995-06-30 Crystalline forms of benzimidazole carboxamide compounds
BR1100564-5A BR1100564A (en) 1992-03-26 1997-05-13 Crystalline forms of endo-2,3-dihydro-n- (8-methyl-8-azabicyclo [3.2.1] oct-3-yl) -2 - -oxo-1h-benzimidazole-1- monohydrate carboxamide and endo-3-ethyl-2,3-dihydro-n- (8-methyl-8-azabicyclo [3.2.1] oc t-3-yl) -2-oxo- monohydrate 1h-benzimidazole-1-carboxamide as 5-ht antagonists
HK98111436A HK1010719A1 (en) 1992-03-26 1998-10-21 Crystalline forms of endo-2,3-dihydro-n-(8-methyl-8- azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h-benzimidazole-1- carboxamide hydrochloride monohydrate and of endo-3-ethyl-2,3-dihydro-n-(8-methyl-8- azabicyclo (3.2.1.)-2-oxo- 1 h-benzimidazole-1- carboxamide hydrochloride monohydrate as 5-ht antagonists
UY25939A UY25939A1 (en) 1992-03-26 2000-01-17 CRYSTALLINE FORMS OF ENDO-2,3-DIHYDRO-N- (8-METHYL-8-AZABICICLO (3.2.1) OCT-3-IL) -2-OXO-1H-BENZMIDAZOLE-1-CARBOXAMIDE AND HYDROCHLORIDE MONOHYDRATE ENDO-3-ETHYL-2,3-DIHYDRO-N- (8-METHYL-8-AZABICICLO (3.2.1) OCT-3- IL) -2- MONOHYDRATE
UY25938A UY25938A1 (en) 1992-03-26 2000-01-17 PROCEDURE FOR PREPARING ENDO-2,3-DIHYDRO-N- (8-METHYL-8-AZABICICLO (3.2.1) OCT-3-IL) -2-OXO-1H-BENZIMIDAZOL-1- CRYSTALLINE FORMS OF HYDROCHLORIDE MONOHYDRATE. ENDO-3-ETHYL -2,3-DIHYDRO-N- (8-METHYL-8-A) CARBOXAMIDE AND HYDROCHLORIDE MONOHYDRATE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI920723A IT1254565B (en) 1992-03-26 1992-03-26 Crystalline form of endo-2,3-dihydro-N-(8-methyl-8- azabicyclo-[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1- carboxamide hydrochloride

Publications (3)

Publication Number Publication Date
ITMI920723A0 ITMI920723A0 (en) 1992-03-26
ITMI920723A1 ITMI920723A1 (en) 1993-09-26
IT1254565B true IT1254565B (en) 1995-09-25

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ITMI920723A IT1254565B (en) 1992-03-26 1992-03-26 Crystalline form of endo-2,3-dihydro-N-(8-methyl-8- azabicyclo-[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1- carboxamide hydrochloride

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IT (1) IT1254565B (en)
ZA (1) ZA932113B (en)

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ZA932113B (en) 1994-09-25
ITMI920723A1 (en) 1993-09-26
ITMI920723A0 (en) 1992-03-26

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