IT1244489B - Controlled release pharmaceutical composition containing a pharmaceutically acceptable salt of buflomedil - Google Patents
Controlled release pharmaceutical composition containing a pharmaceutically acceptable salt of buflomedilInfo
- Publication number
- IT1244489B IT1244489B IT02249390A IT2249390A IT1244489B IT 1244489 B IT1244489 B IT 1244489B IT 02249390 A IT02249390 A IT 02249390A IT 2249390 A IT2249390 A IT 2249390A IT 1244489 B IT1244489 B IT 1244489B
- Authority
- IT
- Italy
- Prior art keywords
- buflomedil
- pharmaceutically acceptable
- acceptable salt
- pharmaceutical composition
- composition containing
- Prior art date
Links
- OWYLAEYXIQKAOL-UHFFFAOYSA-N 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone Chemical compound COC1=CC(OC)=CC(OC)=C1C(=O)CCCN1CCCC1 OWYLAEYXIQKAOL-UHFFFAOYSA-N 0.000 title abstract 2
- 229960001415 buflomedil Drugs 0.000 title abstract 2
- 238000013270 controlled release Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 230000036765 blood level Effects 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 230000006835 compression Effects 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000005550 wet granulation Methods 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to a controlled release pharmaceutical composition containing a pharmaceutically acceptable salt of buflomedil, preferably the hydrochloride. This composition, which is based on the use of a hydrophilic matrix to which normal binding agents and lubricants are mixed is obtained by simple wet granulation followed by compression. In this way tablets having the properties of releasing the active ingredient in a controlled way, thus ensuring constant blood levels for 24 hours, can be obtained.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT02249390A IT1244489B (en) | 1990-12-21 | 1990-12-21 | Controlled release pharmaceutical composition containing a pharmaceutically acceptable salt of buflomedil |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT02249390A IT1244489B (en) | 1990-12-21 | 1990-12-21 | Controlled release pharmaceutical composition containing a pharmaceutically acceptable salt of buflomedil |
Publications (3)
Publication Number | Publication Date |
---|---|
IT9022493A0 IT9022493A0 (en) | 1990-12-21 |
IT9022493A1 IT9022493A1 (en) | 1992-06-21 |
IT1244489B true IT1244489B (en) | 1994-07-15 |
Family
ID=11197011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT02249390A IT1244489B (en) | 1990-12-21 | 1990-12-21 | Controlled release pharmaceutical composition containing a pharmaceutically acceptable salt of buflomedil |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1244489B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102406625A (en) * | 2011-11-28 | 2012-04-11 | 北京四环科宝制药有限公司 | Buflomedil hydrochloride sustained release tablet with high release rate and preparation method thereof |
-
1990
- 1990-12-21 IT IT02249390A patent/IT1244489B/en active IP Right Grant
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102406625A (en) * | 2011-11-28 | 2012-04-11 | 北京四环科宝制药有限公司 | Buflomedil hydrochloride sustained release tablet with high release rate and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
IT9022493A1 (en) | 1992-06-21 |
IT9022493A0 (en) | 1990-12-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971223 |