IT1235029B - Low-dosage zidovudine compsn. for AIDS treatment - Google Patents
Low-dosage zidovudine compsn. for AIDS treatmentInfo
- Publication number
- IT1235029B IT1235029B IT8848388A IT4838888A IT1235029B IT 1235029 B IT1235029 B IT 1235029B IT 8848388 A IT8848388 A IT 8848388A IT 4838888 A IT4838888 A IT 4838888A IT 1235029 B IT1235029 B IT 1235029B
- Authority
- IT
- Italy
- Prior art keywords
- zidovudine
- compsn
- azt
- dosage
- low
- Prior art date
Links
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 title abstract 6
- 229960002555 zidovudine Drugs 0.000 title abstract 6
- 208000030507 AIDS Diseases 0.000 title abstract 2
- QCXJEYYXVJIFCE-UHFFFAOYSA-N 4-acetamidobenzoic acid Chemical compound CC(=O)NC1=CC=C(C(O)=O)C=C1 QCXJEYYXVJIFCE-UHFFFAOYSA-N 0.000 abstract 3
- YLDCUKJMEKGGFI-QCSRICIXSA-N 4-acetamidobenzoic acid;9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one;1-(dimethylamino)propan-2-ol Chemical compound CC(O)CN(C)C.CC(O)CN(C)C.CC(O)CN(C)C.CC(=O)NC1=CC=C(C(O)=O)C=C1.CC(=O)NC1=CC=C(C(O)=O)C=C1.CC(=O)NC1=CC=C(C(O)=O)C=C1.O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(NC=NC2=O)=C2N=C1 YLDCUKJMEKGGFI-QCSRICIXSA-N 0.000 abstract 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 abstract 1
- 229930010555 Inosine Natural products 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000977 initiatory effect Effects 0.000 abstract 1
- 229960003786 inosine Drugs 0.000 abstract 1
- 230000036470 plasma concentration Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Oral or parental compsn. for treatment of AIDS, AIDs-related syndromes and asymptomatic HIV-seropositive patients comprises: (a) zidovudine (AZT); and an amt. of (b) inosiplex; or (b') p-acetamidobenzoic acid (PAB); or (b") PAB and inosine effective for maintaining the AZT plasma level above the therapeutic threshold, the amt. of AZT being ineffective for initiating AZT toxicity and side-effects.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8848388A IT1235029B (en) | 1988-09-28 | 1988-09-28 | Low-dosage zidovudine compsn. for AIDS treatment |
DE8989830422T DE68900926D1 (en) | 1988-09-28 | 1989-09-27 | PHARMACEUTICAL PREPARATION CONTAINING ZIDOVUDINE AND INOSIPLEX, OR INGREDIENTS THEREOF, FOR THE TREATMENT OF AIDS-RELATED SYNDROME. |
AT89830422T ATE72981T1 (en) | 1988-09-28 | 1989-09-27 | PHARMACEUTICAL PREPARATION CONTAINING ZIDOVUDIN AND INOSIPLEX OR INGREDIENTS THEREOF FOR THE TREATMENT OF AIDS-RELATED SYNDROMES. |
ES198989830422T ES2038847T3 (en) | 1988-09-28 | 1989-09-27 | PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION CONTAINING ZIDOVUDINE AND INOSIPLEX FOR THE TREATMENT OF AIDS AND RELATED SYNDROMES. |
EP89830422A EP0362162B1 (en) | 1988-09-28 | 1989-09-27 | Pharmaceutical composition comprising zidovudine and inosiplex or components thereof for the treatment of aids and aids-related syndromes |
JP1251704A JPH02142733A (en) | 1988-09-28 | 1989-09-27 | Aids therapeutic agent containing didobzin |
US07/595,758 US5108993A (en) | 1988-09-28 | 1990-10-09 | Pharmaceutical composition comprising zidovudine and inosiplex or components thereof for the treatment of aids-related syndromes |
GR920400777T GR3004419T3 (en) | 1988-09-28 | 1992-04-20 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8848388A IT1235029B (en) | 1988-09-28 | 1988-09-28 | Low-dosage zidovudine compsn. for AIDS treatment |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8848388A0 IT8848388A0 (en) | 1988-09-28 |
IT1235029B true IT1235029B (en) | 1992-06-17 |
Family
ID=11266261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT8848388A IT1235029B (en) | 1988-09-28 | 1988-09-28 | Low-dosage zidovudine compsn. for AIDS treatment |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1235029B (en) |
-
1988
- 1988-09-28 IT IT8848388A patent/IT1235029B/en active
Also Published As
Publication number | Publication date |
---|---|
IT8848388A0 (en) | 1988-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950721 |