IT1221499B - New sugar derivs. of biologically active peptide(s) - Google Patents

New sugar derivs. of biologically active peptide(s)

Info

Publication number
IT1221499B
IT1221499B IT48490/87A IT4849087A IT1221499B IT 1221499 B IT1221499 B IT 1221499B IT 48490/87 A IT48490/87 A IT 48490/87A IT 4849087 A IT4849087 A IT 4849087A IT 1221499 B IT1221499 B IT 1221499B
Authority
IT
Italy
Prior art keywords
peptide
sugar
biologically active
active peptide
derivs
Prior art date
Application number
IT48490/87A
Other languages
Italian (it)
Other versions
IT8748490A0 (en
Inventor
Rainer Albert
Wilfried Bauer
Francois Cardinaux
Monika Mergler
Janos Pless
Walter Prikoszovich
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IT8748490A0 publication Critical patent/IT8748490A0/en
Application granted granted Critical
Publication of IT1221499B publication Critical patent/IT1221499B/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

New sugar deriv. (I) of a biologically active peptide, with prolonged duration of action when compared with the non-modified peptide, contains at least on one of the amino aicd units a sugar residue attached to an amino gp. by coupling other than a direct N-glycosidic bond, and additionally, when it is a condensation prod. of a carboxyl gp.-contg. sugar and a peptide with less than 8 amino acid units, by a coupling other than a direct amide bond. Also claimed are certain intermediates and the solid phase synthesis of octerotide or a peptide having 2 alcohol gps. or one alcohol gp. and one thiol gp.. A claimed deriv. is (N-desoxyfructosyl-Cys1)-oxytocin.
IT48490/87A 1986-10-13 1987-10-13 New sugar derivs. of biologically active peptide(s) IT1221499B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3634826 1986-10-13
DE3634825 1986-10-13
DE3712626 1987-04-14
CH315387 1987-08-17

Publications (2)

Publication Number Publication Date
IT8748490A0 IT8748490A0 (en) 1987-10-13
IT1221499B true IT1221499B (en) 1990-07-06

Family

ID=27428574

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48490/87A IT1221499B (en) 1986-10-13 1987-10-13 New sugar derivs. of biologically active peptide(s)

Country Status (1)

Country Link
IT (1) IT1221499B (en)

Also Published As

Publication number Publication date
IT8748490A0 (en) 1987-10-13

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