IT1212540B - Sodium cromoglycate-xylometazoline (salt) mixt. - Google Patents
Sodium cromoglycate-xylometazoline (salt) mixt.Info
- Publication number
- IT1212540B IT1212540B IT8224920A IT2492082A IT1212540B IT 1212540 B IT1212540 B IT 1212540B IT 8224920 A IT8224920 A IT 8224920A IT 2492082 A IT2492082 A IT 2492082A IT 1212540 B IT1212540 B IT 1212540B
- Authority
- IT
- Italy
- Prior art keywords
- pref
- mixts
- esp
- xylometazoline
- mixt
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- 229960000833 xylometazoline Drugs 0.000 title abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title 1
- 229910052708 sodium Inorganic materials 0.000 title 1
- 239000011734 sodium Substances 0.000 title 1
- HUCJFAOMUPXHDK-UHFFFAOYSA-N Xylometazoline Chemical compound CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCCN1 HUCJFAOMUPXHDK-UHFFFAOYSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000007922 nasal spray Substances 0.000 abstract 2
- 229940097496 nasal spray Drugs 0.000 abstract 2
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 abstract 1
- 206010027654 Allergic conditions Diseases 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 229960000686 benzalkonium chloride Drugs 0.000 abstract 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 abstract 1
- 210000000795 conjunctiva Anatomy 0.000 abstract 1
- 229960000265 cromoglicic acid Drugs 0.000 abstract 1
- VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 abstract 1
- 239000006196 drop Substances 0.000 abstract 1
- 239000003889 eye drop Substances 0.000 abstract 1
- 229940012356 eye drops Drugs 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 239000003352 sequestering agent Substances 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Mixts. of sodium cromoglycate (I) and xylometazoline (II) or its pharmaceutically acceptable salt are new. The mixts. are pref. aq. solns. pref. contg. 0.5-5% W/V of (I) and 0.01-0.05, esp. 0.025% W/V of (II) as the hydrochloride. The mixts. may contain a sequestering agent (esp. 0.005-0.1% W/V of Na2 EDTA) and preservative (esp. 0.005-0.05% W/V of benzalkonium chloride). Pref. pH is 4.5-6.5. Compsn. may be used in treatment of hayfever, e.g. as a nasal spray, and in treatment of e.g. allergic conditions of the conjunctiva. Nasal spray admin. is pref. from a 2% soln. of (I), giving ca. 3 mg for each nostril, 2-6 times daily. Eye drops are pref. admin. at 1-2 drops/eye up to 10 times daily. Concn. of (II) may be radically reduced while retaining duration and effect, thus reducing the risk of side effects associated with vasonstrictors. The mixt. is more efficacious than (I) above and (II) prolongs the action of (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8138755 | 1981-12-23 | ||
| EP82201545A EP0082546B2 (en) | 1981-12-23 | 1982-12-06 | Pharmaceutical mixture and method for making the mixture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8224920A0 IT8224920A0 (en) | 1982-12-22 |
| IT1212540B true IT1212540B (en) | 1989-11-30 |
Family
ID=26084906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT8224920A IT1212540B (en) | 1981-12-23 | 1982-12-22 | Sodium cromoglycate-xylometazoline (salt) mixt. |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1212540B (en) |
-
1982
- 1982-12-22 IT IT8224920A patent/IT1212540B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| IT8224920A0 (en) | 1982-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19961227 |