IT1206322B - Methyl-bis:di:methoxy-phenyl-ethylamine - Google Patents
Methyl-bis:di:methoxy-phenyl-ethylamineInfo
- Publication number
- IT1206322B IT1206322B IT8320838A IT2083883A IT1206322B IT 1206322 B IT1206322 B IT 1206322B IT 8320838 A IT8320838 A IT 8320838A IT 2083883 A IT2083883 A IT 2083883A IT 1206322 B IT1206322 B IT 1206322B
- Authority
- IT
- Italy
- Prior art keywords
- bis
- methyl
- ethylamine
- methoxy
- phenyl
- Prior art date
Links
- FEGKXZFSOCPQJH-UHFFFAOYSA-N n-methoxy-2-phenylethanamine Chemical compound CONCCC1=CC=CC=C1 FEGKXZFSOCPQJH-UHFFFAOYSA-N 0.000 title 1
- YSAXSWPDOFHENC-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-n-[2-(3,4-dimethoxyphenyl)ethyl]ethanamine Chemical compound C1=C(OC)C(OC)=CC=C1CCNCCC1=CC=C(OC)C(OC)=C1 YSAXSWPDOFHENC-UHFFFAOYSA-N 0.000 abstract 2
- -1 3,4-dimethoxy-phenylethyl Chemical group 0.000 abstract 1
- 229940127291 Calcium channel antagonist Drugs 0.000 abstract 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000000480 calcium channel blocker Substances 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 238000006485 reductive methylation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
N-Methyl-N,N-bis (3,4-dimethoxy-phenylethyl) amine of formula (I) and its acid-addn. salts is new. (I) may be prepd. by reductive methylation of bis(3,4-dimethoxyphenylethyl)amine (II) with HCHO in a reducing medium. (I) is a calcium antagonist with comparable activity to nifedipin, e.g. useful for treating myocardial ischemia and cerebrovascular disorders. Effective oral doses are 20-150 mg/day. (FL)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8320838A IT1206322B (en) | 1983-04-28 | 1983-04-28 | Methyl-bis:di:methoxy-phenyl-ethylamine |
CH3684/83A CH654294A5 (en) | 1982-07-09 | 1983-07-05 | CARDIAC AND CEREBRAL LEVEL CALCIUM BLOCKING COMPOUNDS, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS. |
CA000431900A CA1238858A (en) | 1982-07-09 | 1983-07-06 | Pharmaceutical compositions having calcium blocking activity |
GB08318467A GB2126213B (en) | 1982-07-09 | 1983-07-07 | Calcium blocking bis(methoxyphenyl)amine |
ES524353A ES8500885A1 (en) | 1982-07-09 | 1983-07-08 | Compounds having calcium blocking activity |
FR8311387A FR2541113B1 (en) | 1982-07-09 | 1983-07-08 | THERAPEUTIC APPLICATION OF N-METHYL-N-BIS (3,4-DIMETHOXYPHENYLETHYL) AMINE AND ITS ADDITION SALTS WITH PHARMACEUTICALLY ACCEPTABLE ACIDS |
DE3324727A DE3324727A1 (en) | 1982-07-09 | 1983-07-08 | N-METHYL-N-BIS- (3,4-DIMETHOXYPHENYLAETHYL) AMINE, ITS SALTS WITH ACIDS, MEDICINAL PRODUCTS AND ITS USE IN THE TREATMENT OF CARDIOVASCULAR DISEASES AND CERBRAL BLOOD DISEASES |
NLAANVRAGE8302451,A NL185666C (en) | 1982-07-09 | 1983-07-08 | PHARMACEUTICAL PREPARATION OR ARTICLE AND MEDICINAL COMPOUNDS. |
US06/691,157 US4956389A (en) | 1982-07-09 | 1985-01-14 | Compounds having calcium blocking activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8320838A IT1206322B (en) | 1983-04-28 | 1983-04-28 | Methyl-bis:di:methoxy-phenyl-ethylamine |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8320838A0 IT8320838A0 (en) | 1983-04-28 |
IT1206322B true IT1206322B (en) | 1989-04-14 |
Family
ID=11172807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT8320838A IT1206322B (en) | 1982-07-09 | 1983-04-28 | Methyl-bis:di:methoxy-phenyl-ethylamine |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1206322B (en) |
-
1983
- 1983-04-28 IT IT8320838A patent/IT1206322B/en active
Also Published As
Publication number | Publication date |
---|---|
IT8320838A0 (en) | 1983-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950427 |