IT1205014B - New nootropic N-substd. isoxazole-5-carboxamide(s) - Google Patents
New nootropic N-substd. isoxazole-5-carboxamide(s)Info
- Publication number
- IT1205014B IT1205014B IT20589/87A IT2058987A IT1205014B IT 1205014 B IT1205014 B IT 1205014B IT 20589/87 A IT20589/87 A IT 20589/87A IT 2058987 A IT2058987 A IT 2058987A IT 1205014 B IT1205014 B IT 1205014B
- Authority
- IT
- Italy
- Prior art keywords
- substd
- isoxazole
- alkyl
- carboxamide
- alkoxy
- Prior art date
Links
- DSIBSRXKQRYPJP-UHFFFAOYSA-N 1,2-oxazole-5-carboxamide Chemical compound NC(=O)C1=CC=NO1 DSIBSRXKQRYPJP-UHFFFAOYSA-N 0.000 title 1
- 230000001777 nootropic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Isoxazole cpds. of the formula (I) and their salts are new, where n is 1 or 2; R is H, halogen, 0H or 1-6C alkyl or alkoxy; R1 is 0H, opt. unsatd. 1-18C alkoxy or NR2R3; R2 and R3 are each independently H, 1-6C alkyl or -(CH2)mR4 where m is 1-3 and R4 is carboxy, (1-6C alkoxy)-carbonyl or NR5R6 in which R5 and R6 are each independently H or 1-6C alkyl; or one of R2 and R3 is -CHR4R7 where R7 is 1-4C alkyl opt. substd. by phenyl, 0H or SH, and the other is H; or -NR2R3 is a 5- to 7-membered heterocycle opt. further contg. one or two heteroatoms selected from 0,N and S.
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT20589/87A IT1205014B (en) | 1987-05-20 | 1987-05-20 | New nootropic N-substd. isoxazole-5-carboxamide(s) |
DE8888904406T DE3864124D1 (en) | 1987-05-20 | 1988-05-19 | ISOXAZOLES WITH NOOTROPICAL EFFECT. |
AT88904406T ATE65997T1 (en) | 1987-05-20 | 1988-05-19 | ISOXAZOLE WITH NOOTROPIC ACTION. |
PCT/EP1988/000445 WO1988009330A1 (en) | 1987-05-20 | 1988-05-19 | Isoxazoles with nootropic activity |
JP63504091A JPH02500365A (en) | 1987-05-20 | 1988-05-19 | Compounds with cognitive aids |
AU17869/88A AU599809B2 (en) | 1987-05-20 | 1988-05-19 | Isoxazoles with nootropic activity |
US07/302,747 US4985428A (en) | 1987-05-20 | 1988-05-19 | Isoxazoles with nootropic activity |
EP88904406A EP0317588B1 (en) | 1987-05-20 | 1988-05-19 | Isoxazoles with nootropic activity |
DK004389A DK4389A (en) | 1987-05-20 | 1989-01-06 | ISOXAZOLES WITH NOOTROP EFFECT |
FI890173A FI89266C (en) | 1987-05-20 | 1989-01-13 | FREQUENCY FRAME RELEASE WITH NOXROPICAL NETWORK |
NO890245A NO172120C (en) | 1987-05-20 | 1989-01-19 | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE ISOXAZOLS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT20589/87A IT1205014B (en) | 1987-05-20 | 1987-05-20 | New nootropic N-substd. isoxazole-5-carboxamide(s) |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8720589A0 IT8720589A0 (en) | 1987-05-20 |
IT1205014B true IT1205014B (en) | 1989-03-10 |
Family
ID=11169235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT20589/87A IT1205014B (en) | 1987-05-20 | 1987-05-20 | New nootropic N-substd. isoxazole-5-carboxamide(s) |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1205014B (en) |
-
1987
- 1987-05-20 IT IT20589/87A patent/IT1205014B/en active
Also Published As
Publication number | Publication date |
---|---|
IT8720589A0 (en) | 1987-05-20 |
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