IT1204457B - New di:hydro-pyridine cpds. for treating cardiovascular disorders - Google Patents
New di:hydro-pyridine cpds. for treating cardiovascular disordersInfo
- Publication number
- IT1204457B IT1204457B IT19479/86A IT1947986A IT1204457B IT 1204457 B IT1204457 B IT 1204457B IT 19479/86 A IT19479/86 A IT 19479/86A IT 1947986 A IT1947986 A IT 1947986A IT 1204457 B IT1204457 B IT 1204457B
- Authority
- IT
- Italy
- Prior art keywords
- alkyl
- new
- hydro
- cardiovascular disorders
- treating cardiovascular
- Prior art date
Links
- 208000024172 Cardiovascular disease Diseases 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004848 alkoxyethyl group Chemical group 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Dihydropyridine derivs. of formula (I) are new. R1 and R4 = 1-4C alkyl; R2 and R3 = 1-6C alkyl or alkoxyalkyl; R5 = 1-13C alkyl or 5-8C cycloalkyl (opt. substd. by 1-3C alkyl); R6 = halo or 1-3C alkyl. Intermediates (II) of formula (I; R5=H) are also new. Pref. R1 and R4 = Me or Et (esp. Me); R2 and R3 = 1-4C alkyl (esp. Me, Et or iPr) or 1-3C alkoxyethyl; R5 = 2-9C alkyl (esp. Et, Pr, S-Bu, t-Bu, pentyl or octyl) or 5-7C cycloalkyl opt. substd. by 1-3C alkyl (esp. cyclohexyl); R6 = Br, Me or Et.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19479/86A IT1204457B (en) | 1986-02-20 | 1986-02-20 | New di:hydro-pyridine cpds. for treating cardiovascular disorders |
| EP86306456A EP0226271B1 (en) | 1985-08-21 | 1986-08-20 | 1,4-dihydropyridine compounds and their preparation and pharmaceutical formulation |
| DE8686306456T DE3675747D1 (en) | 1985-08-21 | 1986-08-20 | 1,4-DIHYDROPYRIDINE COMPOUNDS AND THEIR PRODUCTION AND PHARMACEUTICAL FORMULATION. |
| AT86306456T ATE58530T1 (en) | 1985-08-21 | 1986-08-20 | 1,4-DIHYDROPYRIDINE COMPOUNDS AND THEIR PRODUCTION AND PHARMACEUTICAL FORMULATION. |
| US07/270,487 US5091395A (en) | 1985-08-21 | 1988-11-04 | Heterocyclic compounds and their pharmaceutical formulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19479/86A IT1204457B (en) | 1986-02-20 | 1986-02-20 | New di:hydro-pyridine cpds. for treating cardiovascular disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8619479A0 IT8619479A0 (en) | 1986-02-20 |
| IT1204457B true IT1204457B (en) | 1989-03-01 |
Family
ID=11158371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT19479/86A IT1204457B (en) | 1985-08-21 | 1986-02-20 | New di:hydro-pyridine cpds. for treating cardiovascular disorders |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1204457B (en) |
-
1986
- 1986-02-20 IT IT19479/86A patent/IT1204457B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| IT8619479A0 (en) | 1986-02-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19940218 |