IT1203703B - Storage stable antiinflammatory eye drops - Google Patents
Storage stable antiinflammatory eye dropsInfo
- Publication number
- IT1203703B IT1203703B IT21223/83A IT2122383A IT1203703B IT 1203703 B IT1203703 B IT 1203703B IT 21223/83 A IT21223/83 A IT 21223/83A IT 2122383 A IT2122383 A IT 2122383A IT 1203703 B IT1203703 B IT 1203703B
- Authority
- IT
- Italy
- Prior art keywords
- eye drops
- antiinflammatory
- stable
- storage stable
- peroxycam
- Prior art date
Links
- 239000003889 eye drop Substances 0.000 title abstract 2
- 229940012356 eye drops Drugs 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 abstract 1
- 229910000397 disodium phosphate Inorganic materials 0.000 abstract 1
- 235000019800 disodium phosphate Nutrition 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001488 sodium phosphate Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Eye drops containing peroxycam (4-hydroxy -2-methyl(-N-2-pyridyl -2-1,2-benzothiadiazine -3-carboxamide -1,1-dioxide) in hypertonic sterile aqueous solution. The compsns. are pref. completely free from metal ions and, in addn. to the piroxycam, they contain Na or Ca EDTA, a buffer, such as disodium phosphate, together with stabilisers. They are stored in sealed containers under nitrogen, where they are stable for over two years, and, when opened and a dropper inserted, they are stable for 30 days.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT21223/83A IT1203703B (en) | 1983-05-23 | 1983-05-23 | Storage stable antiinflammatory eye drops |
BE0/212886A BE899587A (en) | 1983-05-23 | 1984-05-04 | PHARMACEUTICAL COMPOSITION OF THE EYE DROPS WITH ANTI-INFLAMMATORY ACTIVITY, AND PROCESS FOR PREPARING THE SAME. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT21223/83A IT1203703B (en) | 1983-05-23 | 1983-05-23 | Storage stable antiinflammatory eye drops |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8321223A0 IT8321223A0 (en) | 1983-05-23 |
IT1203703B true IT1203703B (en) | 1989-02-15 |
Family
ID=11178629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT21223/83A IT1203703B (en) | 1983-05-23 | 1983-05-23 | Storage stable antiinflammatory eye drops |
Country Status (2)
Country | Link |
---|---|
BE (1) | BE899587A (en) |
IT (1) | IT1203703B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5362758A (en) * | 1992-09-18 | 1994-11-08 | Pfizer Inc. | Ophthalmic piroxicam solution |
ATA156496A (en) * | 1996-09-03 | 1997-10-15 | Nycomed Austria Gmbh | PHARMACEUTICAL COMPOSITION |
-
1983
- 1983-05-23 IT IT21223/83A patent/IT1203703B/en active
-
1984
- 1984-05-04 BE BE0/212886A patent/BE899587A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BE899587A (en) | 1984-08-31 |
IT8321223A0 (en) | 1983-05-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970529 |