IT1196502B - New partly retro-inverted tuftsin analogues - Google Patents

New partly retro-inverted tuftsin analogues

Info

Publication number
IT1196502B
IT1196502B IT21145/86A IT2114586A IT1196502B IT 1196502 B IT1196502 B IT 1196502B IT 21145/86 A IT21145/86 A IT 21145/86A IT 2114586 A IT2114586 A IT 2114586A IT 1196502 B IT1196502 B IT 1196502B
Authority
IT
Italy
Prior art keywords
new
tuftsin
analogues
chain
inverted
Prior art date
Application number
IT21145/86A
Other languages
Italian (it)
Other versions
IT8621145A0 (en
Inventor
Antonio Silvio Verdini
Fabio Bonelli
Antonello Pessi
Franco Cardinali
Diano Boraschi
Stefano Censini
Original Assignee
Eniricerche Spa
Sclavo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche Spa, Sclavo Spa filed Critical Eniricerche Spa
Publication of IT8621145A0 publication Critical patent/IT8621145A0/en
Priority to IT21145/86A priority Critical patent/IT1196502B/en
Priority to AT87109318T priority patent/ATE84044T1/en
Priority to EP87109318A priority patent/EP0253190B1/en
Priority to ES87109318T priority patent/ES2052517T3/en
Priority to DE8787109318T priority patent/DE3783280T2/en
Priority to CA000541628A priority patent/CA1318457C/en
Priority to US07/074,054 priority patent/US4816560A/en
Priority to JP62176064A priority patent/JPH0832720B2/en
Application granted granted Critical
Publication of IT1196502B publication Critical patent/IT1196502B/en
Priority to GR920403197T priority patent/GR3007494T3/el

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  • Peptides Or Proteins (AREA)

Abstract

(1) Partly retroinverted tuftsin analogues of formula (I) and their salts, esters and amides are new. R = side-chain of threonine, methionine or leucine; R1 = side-chain of lysine or arginine; R2 = H or metabolically labile acyl gp. (2) Intermediates of formula (II) are new. R1' = side-chain of lysine or arginine in which the amino or guanidino gp. is suitably protected; P'' = easily removable carboxyl protecting gp.; P' = easily removable guanidino protecting gp.; R' = side-chain of threonine, methionine or leucine in which any functional gps. are suitably protected. Also corresp. cpds. in which the protecting gps. have been removed are new.
IT21145/86A 1986-07-16 1986-07-16 New partly retro-inverted tuftsin analogues IT1196502B (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT21145/86A IT1196502B (en) 1986-07-16 1986-07-16 New partly retro-inverted tuftsin analogues
DE8787109318T DE3783280T2 (en) 1986-07-16 1987-06-29 PARTIAL RETRO-INVERTED ANALOGS OF TUFTSIN, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE IT.
EP87109318A EP0253190B1 (en) 1986-07-16 1987-06-29 Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
ES87109318T ES2052517T3 (en) 1986-07-16 1987-06-29 ANALOGS OF TUFTSINA PARTIALLY RETROINVERSE, METHOD OF PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
AT87109318T ATE84044T1 (en) 1986-07-16 1987-06-29 PARTIAL RETRO-INVERTED ANALOGUES OF THE TUFTSIN, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEY CONTAIN.
CA000541628A CA1318457C (en) 1986-07-16 1987-07-08 Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
US07/074,054 US4816560A (en) 1986-07-16 1987-07-16 Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
JP62176064A JPH0832720B2 (en) 1986-07-16 1987-07-16 Tuftsin analogs, process for their preparation and pharmaceutical compositions
GR920403197T GR3007494T3 (en) 1986-07-16 1993-03-30

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21145/86A IT1196502B (en) 1986-07-16 1986-07-16 New partly retro-inverted tuftsin analogues

Publications (2)

Publication Number Publication Date
IT8621145A0 IT8621145A0 (en) 1986-07-16
IT1196502B true IT1196502B (en) 1988-11-16

Family

ID=11177404

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21145/86A IT1196502B (en) 1986-07-16 1986-07-16 New partly retro-inverted tuftsin analogues

Country Status (1)

Country Link
IT (1) IT1196502B (en)

Also Published As

Publication number Publication date
IT8621145A0 (en) 1986-07-16

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