IT1195313B - Non-steroid antiinflammatory acid derivs. - Google Patents

Non-steroid antiinflammatory acid derivs.

Info

Publication number
IT1195313B
IT1195313B IT49735/80A IT4973580A IT1195313B IT 1195313 B IT1195313 B IT 1195313B IT 49735/80 A IT49735/80 A IT 49735/80A IT 4973580 A IT4973580 A IT 4973580A IT 1195313 B IT1195313 B IT 1195313B
Authority
IT
Italy
Prior art keywords
hydroxymethyl
tris
methyl
amino
methane
Prior art date
Application number
IT49735/80A
Other languages
Italian (it)
Other versions
IT8049735A0 (en
IT8049735A1 (en
Inventor
Ilona Kahan
Original Assignee
Ilona Kahan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU79KA1539A external-priority patent/HU185926B/en
Priority claimed from HU801539A external-priority patent/HU183156B/en
Application filed by Ilona Kahan filed Critical Ilona Kahan
Publication of IT8049735A0 publication Critical patent/IT8049735A0/en
Publication of IT8049735A1 publication Critical patent/IT8049735A1/en
Application granted granted Critical
Publication of IT1195313B publication Critical patent/IT1195313B/en

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel derivs. (I) of non-steroid antiinflammatory acids (II) comprise (a) a cpd. (II) with an aromatic nucleus, one or more hydrophobic side-chain(s) and a carboxylic acid gp. and (b) a hydrophilic component consisting of tris-(hydroxymethyl)-amino-methane; (bis-(2-hydroxyethyl) amino tris-(hydroxymethyl)-methane; 1,3-bis-(tris-(hydroxymethyl) methyl) -aminopropane; 3-(tris-(hydroxymethyl)-methyl) -amino-propane- sulphonic acid; 2-(tris-(hydroxymethyl)-methyl) -amino-ethane- sulphonic acid, and/or N-(tris-(hydroxymethyl) -methyl)-glycine. (I) are antiinflammatory, antipyretic and analgesic agents which inhibit prostaglandin synthesis in vitro. They are stable (e.g. can be stored for years as powder), water-soluble and also lipid-soluble. They can be used locally (e.g. as eye-drops or ointments) or by injection (e.g. i.v., i.m. or intra-articular), and are more effective and/or have less side-effects c.f. oral admin. of the parent cpd. (II).
IT49735/80A 1979-09-27 1980-09-25 Non-steroid antiinflammatory acid derivs. IT1195313B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU79KA1539A HU185926B (en) 1979-09-27 1979-09-27 Process for preparing water soluble derivatives of non-steroid antiinflammatory compositions and pharmaceutical compositins containing such derivatives
HU801539A HU183156B (en) 1979-06-21 1980-08-21 Process for producing pyrqzolo-quinoline derivatives

Publications (3)

Publication Number Publication Date
IT8049735A0 IT8049735A0 (en) 1980-09-25
IT8049735A1 IT8049735A1 (en) 1982-03-25
IT1195313B true IT1195313B (en) 1988-10-12

Family

ID=26317387

Family Applications (1)

Application Number Title Priority Date Filing Date
IT49735/80A IT1195313B (en) 1979-09-27 1980-09-25 Non-steroid antiinflammatory acid derivs.

Country Status (6)

Country Link
DK (1) DK408780A (en)
FI (1) FI803043A (en)
IL (1) IL61308A (en)
IT (1) IT1195313B (en)
PL (1) PL129782B1 (en)
YU (1) YU243980A (en)

Also Published As

Publication number Publication date
DK408780A (en) 1981-03-28
FI803043A (en) 1981-03-28
IL61308A (en) 1984-06-29
IT8049735A0 (en) 1980-09-25
IT8049735A1 (en) 1982-03-25
PL129782B1 (en) 1984-06-30
PL226938A1 (en) 1981-10-16
YU243980A (en) 1983-04-30

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