IT1190884B - Vaccine against diarrhoeal diseases - Google Patents

Vaccine against diarrhoeal diseases

Info

Publication number
IT1190884B
IT1190884B IT22000/82A IT2200082A IT1190884B IT 1190884 B IT1190884 B IT 1190884B IT 22000/82 A IT22000/82 A IT 22000/82A IT 2200082 A IT2200082 A IT 2200082A IT 1190884 B IT1190884 B IT 1190884B
Authority
IT
Italy
Prior art keywords
heat
vaccine
coli
subunit
labile
Prior art date
Application number
IT22000/82A
Other languages
Italian (it)
Other versions
IT8222000A0 (en
Inventor
Frederick A Klipstein
Richard F Engert
John D Clements
Original Assignee
Univ Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1982/000763 external-priority patent/WO1983000018A1/en
Application filed by Univ Rochester filed Critical Univ Rochester
Publication of IT8222000A0 publication Critical patent/IT8222000A0/en
Application granted granted Critical
Publication of IT1190884B publication Critical patent/IT1190884B/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Vaccine for immunisation of mammals against diarrhoeal diseases comprises the reaction prod. of heat-stable enterotoxin of Escherichia coli with heat-labile enterotoxin of E.coli or cholera toxin of Vibrio cholerae (both in the form of holotoxin or just the B subunit) in presence of a conjugating agent (I). The vaccine is non-toxic but is effective in protecting mammals against acute diarrhoeal disease caused by enterotoxigenic strains of E.coli producing heat-labile and/or heat stable toxins. In the vaccine the toxic properties of the individual toxin are reduced while their antigenicity is retained, an the property of the B subunit to adhere to specific mucosal receptors is maintained. The vaccines are administered parenterally or perorally.
IT22000/82A 1981-06-22 1982-06-22 Vaccine against diarrhoeal diseases IT1190884B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27640981A 1981-06-22 1981-06-22
PCT/US1982/000763 WO1983000018A1 (en) 1981-06-22 1982-06-03 Composition of a novel immunogen for protection against diarrheal disease caused by enterotoxigenic escherichia coli

Publications (2)

Publication Number Publication Date
IT8222000A0 IT8222000A0 (en) 1982-06-22
IT1190884B true IT1190884B (en) 1988-02-24

Family

ID=26766545

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22000/82A IT1190884B (en) 1981-06-22 1982-06-22 Vaccine against diarrhoeal diseases

Country Status (3)

Country Link
CA (1) CA1183453A (en)
IT (1) IT1190884B (en)
NZ (1) NZ201027A (en)

Also Published As

Publication number Publication date
NZ201027A (en) 1985-05-31
IT8222000A0 (en) 1982-06-22
CA1183453A (en) 1985-03-05

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