IT1166592B - Redn. of blood lipid levels in animals - by admin. of 2-alkyl-3-amino-4-carboxy-thiophene deriv. - Google Patents
Redn. of blood lipid levels in animals - by admin. of 2-alkyl-3-amino-4-carboxy-thiophene deriv.Info
- Publication number
- IT1166592B IT1166592B IT1956979A IT1956979A IT1166592B IT 1166592 B IT1166592 B IT 1166592B IT 1956979 A IT1956979 A IT 1956979A IT 1956979 A IT1956979 A IT 1956979A IT 1166592 B IT1166592 B IT 1166592B
- Authority
- IT
- Italy
- Prior art keywords
- alkyl
- redn
- admin
- blood lipid
- deriv
- Prior art date
Links
- 239000008280 blood Substances 0.000 title abstract 2
- 210000004369 blood Anatomy 0.000 title abstract 2
- 241001465754 Metazoa Species 0.000 title 1
- 150000002632 lipids Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 210000000577 adipose tissue Anatomy 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000000883 anti-obesity agent Substances 0.000 abstract 1
- 239000003524 antilipemic agent Substances 0.000 abstract 1
- 229940125710 antiobesity agent Drugs 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The redn. is effected by admin. of a cpd. of formula (I) or its salts. (R is 1-8C alkyl; R2 is H, OH, 1-8C alkoxy or NH2; and R3 and R4 are 1-8C alkyl, aryl, aralkyl or H). (I) are blood lipid lowering and antiobesity agents, and so they are useful for the treatment of atherosclerosis and related cardiovascular diseases. They selectively reduce body fat by inhibiting its biosynthesis. The cpds. are described in U.S. 4317915 (22048 E/11). The cpd. in which R and R2 are Me and R3 and R4 are H is pref. used.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88945978A | 1978-03-23 | 1978-03-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7919569A0 IT7919569A0 (en) | 1979-01-24 |
IT1166592B true IT1166592B (en) | 1987-05-05 |
Family
ID=25395141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT1956979A IT1166592B (en) | 1978-03-23 | 1979-01-24 | Redn. of blood lipid levels in animals - by admin. of 2-alkyl-3-amino-4-carboxy-thiophene deriv. |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1166592B (en) |
-
1979
- 1979-01-24 IT IT1956979A patent/IT1166592B/en active
Also Published As
Publication number | Publication date |
---|---|
IT7919569A0 (en) | 1979-01-24 |
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