IT1163037B - Procedimento di sintesi di peptidi e agenti di bloccaggio di amminoacidi - Google Patents
Procedimento di sintesi di peptidi e agenti di bloccaggio di amminoacidiInfo
- Publication number
- IT1163037B IT1163037B IT19160/83A IT1916083A IT1163037B IT 1163037 B IT1163037 B IT 1163037B IT 19160/83 A IT19160/83 A IT 19160/83A IT 1916083 A IT1916083 A IT 1916083A IT 1163037 B IT1163037 B IT 1163037B
- Authority
- IT
- Italy
- Prior art keywords
- peptides
- amino acids
- blocking agents
- synthesis procedure
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/342,296 US4394519A (en) | 1982-01-19 | 1982-01-19 | Amino acid blocking agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8319160A0 IT8319160A0 (it) | 1983-01-18 |
| IT1163037B true IT1163037B (it) | 1987-04-08 |
Family
ID=23341209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT19160/83A IT1163037B (it) | 1982-01-19 | 1983-01-18 | Procedimento di sintesi di peptidi e agenti di bloccaggio di amminoacidi |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4394519A (it) |
| EP (1) | EP0098865B1 (it) |
| JP (1) | JPS58502207A (it) |
| DE (1) | DE3279468D1 (it) |
| GR (1) | GR77185B (it) |
| IE (1) | IE54589B1 (it) |
| IT (1) | IT1163037B (it) |
| WO (1) | WO1983002448A1 (it) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4581167A (en) * | 1982-01-19 | 1986-04-08 | Research Corporation | Peptide synthesis and amino acid blocking agents |
| US5164515A (en) * | 1986-03-26 | 1992-11-17 | Wendstone Chemicals Plc | Chemical compounds |
| CA2018542A1 (en) * | 1989-06-09 | 1990-12-09 | Louis A. Carpino | Reagents for rapid peptide synthesis |
| US5221754A (en) * | 1989-06-09 | 1993-06-22 | Research Corporation Technologies, Inc. | Reagents for rapid peptide synthesis |
| US5278174A (en) * | 1990-06-04 | 1994-01-11 | Scios Nova, Inc. | Sigma binding site agents |
| JP3134936B2 (ja) * | 1992-10-16 | 2001-02-13 | 沖電気工業株式会社 | 衝撃センサ |
| US6307090B1 (en) | 1999-01-22 | 2001-10-23 | The United States Of America As Represented By The Department Of Health And Human Services | Acylated oligopeptide derivatives having cell signal inhibiting activity |
| US7226991B1 (en) * | 1999-03-23 | 2007-06-05 | United States Of America, Represented By The Secretary, Department Of Health And Human Services | Phenylalanine derivatives |
| EP1163262B1 (en) * | 1999-03-23 | 2011-05-11 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Phenylalanine derivatives |
| JP2003512334A (ja) | 1999-10-22 | 2003-04-02 | アメリカ合衆国 | Ｇｒｂ−２ｓｈ−２ドメインの阻害剤による細胞運動性及び脈管形成の阻害 |
| US7871981B2 (en) * | 1999-10-22 | 2011-01-18 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of cell motility, angiogenesis, and metastasis |
| US6977241B2 (en) * | 2000-08-22 | 2005-12-20 | The United States Of America As Represented By The Department Of Health & Human Services | SH2 domain binding inhibitors |
| US7425537B2 (en) * | 2000-08-22 | 2008-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SH2 domain binding inhibitors |
| AU2003298726A1 (en) * | 2002-11-25 | 2004-08-10 | Attenuon Llc | Peptides which target tumor and endothelial cells, compositions and uses thereof |
| US20040138104A1 (en) * | 2003-01-14 | 2004-07-15 | The Government Of The United States Of America Represented By The Secretary, | Peptides |
| US20050119163A1 (en) * | 2003-09-18 | 2005-06-02 | The Government Of The United States Of America, As Represented By The Secretary, | SH2 domain binding inhibitors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2723972A (en) * | 1954-04-28 | 1955-11-15 | Du Pont | Homocysteinyl heterodipeptides |
| US3062805A (en) * | 1957-03-08 | 1962-11-06 | Sterling Drug Inc | Peptide synthesis and intermediates therefor |
| US2870057A (en) * | 1957-11-26 | 1959-01-20 | Gulf Research Development Co | 4- or 5-indanyl n-methyl carbamate |
| US3510504A (en) * | 1965-01-21 | 1970-05-05 | Lilly Co Eli | Adamantyloxycarbonyl derivatives of alpha-amino acids |
| US3467690A (en) * | 1965-05-12 | 1969-09-16 | Lilly Co Eli | 3,5-dimethoxybenzyl carbonate esters |
| US3875207A (en) * | 1967-01-25 | 1975-04-01 | Ciba Geigy Corp | Process for the temporary protection of amino groups in peptide syntheses |
| US3532736A (en) * | 1967-11-29 | 1970-10-06 | Lilly Co Eli | Novel amino acid protecting group |
| NL7103339A (it) * | 1970-03-19 | 1971-09-21 | Hoechst Ag | |
| US3906031A (en) * | 1971-03-15 | 1975-09-16 | Research Corp | Novel 9-fluorenylmethoxycarbonyl compounds |
| US3891692A (en) * | 1972-05-03 | 1975-06-24 | Merck & Co Inc | N-(cyclopropylalkoxycarbonyl)amino acids |
| US4108854A (en) * | 1975-06-24 | 1978-08-22 | Smithkline Corporation | Process for preparing substituted glycines |
-
1982
- 1982-01-19 US US06/342,296 patent/US4394519A/en not_active Expired - Fee Related
- 1982-12-23 DE DE8383900467T patent/DE3279468D1/de not_active Expired
- 1982-12-23 WO PCT/US1982/001785 patent/WO1983002448A1/en active IP Right Grant
- 1982-12-23 EP EP83900467A patent/EP0098865B1/en not_active Expired
- 1982-12-23 JP JP83500351A patent/JPS58502207A/ja active Pending
-
1983
- 1983-01-14 GR GR70260A patent/GR77185B/el unknown
- 1983-01-18 IT IT19160/83A patent/IT1163037B/it active
- 1983-01-18 IE IE85/83A patent/IE54589B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT8319160A0 (it) | 1983-01-18 |
| IE54589B1 (en) | 1989-12-06 |
| JPS58502207A (ja) | 1983-12-22 |
| EP0098865A1 (en) | 1984-01-25 |
| GR77185B (it) | 1984-09-11 |
| IE830085L (en) | 1983-07-19 |
| EP0098865B1 (en) | 1989-03-01 |
| US4394519A (en) | 1983-07-19 |
| DE3279468D1 (en) | 1989-04-06 |
| EP0098865A4 (en) | 1986-11-20 |
| WO1983002448A1 (en) | 1983-07-21 |
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