IT1148008B - N- (CYCLOALKYL) AMINO ACID COMPOUNDS USEFUL AS INHIBITORS OF THE ANGIOTENSIN CONVERSION ENZYME I - Google Patents

N- (CYCLOALKYL) AMINO ACID COMPOUNDS USEFUL AS INHIBITORS OF THE ANGIOTENSIN CONVERSION ENZYME I

Info

Publication number
IT1148008B
IT1148008B IT48270/81A IT4827081A IT1148008B IT 1148008 B IT1148008 B IT 1148008B IT 48270/81 A IT48270/81 A IT 48270/81A IT 4827081 A IT4827081 A IT 4827081A IT 1148008 B IT1148008 B IT 1148008B
Authority
IT
Italy
Prior art keywords
cycloalkyl
inhibitors
amino acid
acid compounds
compounds useful
Prior art date
Application number
IT48270/81A
Other languages
Italian (it)
Other versions
IT8148270A0 (en
Inventor
Ralph L White Jr
Original Assignee
Morton Norwich Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morton Norwich Products Inc filed Critical Morton Norwich Products Inc
Publication of IT8148270A0 publication Critical patent/IT8148270A0/en
Application granted granted Critical
Publication of IT1148008B publication Critical patent/IT1148008B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • C07C327/20Esters of monothiocarboxylic acids
    • C07C327/32Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/18Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT48270/81A 1980-06-09 1981-04-13 N- (CYCLOALKYL) AMINO ACID COMPOUNDS USEFUL AS INHIBITORS OF THE ANGIOTENSIN CONVERSION ENZYME I IT1148008B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15742080A 1980-06-09 1980-06-09

Publications (2)

Publication Number Publication Date
IT8148270A0 IT8148270A0 (en) 1981-04-13
IT1148008B true IT1148008B (en) 1986-11-26

Family

ID=22563635

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48270/81A IT1148008B (en) 1980-06-09 1981-04-13 N- (CYCLOALKYL) AMINO ACID COMPOUNDS USEFUL AS INHIBITORS OF THE ANGIOTENSIN CONVERSION ENZYME I

Country Status (16)

Country Link
JP (1) JPS5726656A (en)
AU (1) AU6808181A (en)
BE (1) BE889152A (en)
DD (1) DD159069A5 (en)
DE (1) DE3122541A1 (en)
DK (1) DK247181A (en)
ES (1) ES502153A0 (en)
FR (1) FR2483916A1 (en)
GB (1) GB2077719A (en)
GR (1) GR82349B (en)
IL (1) IL62293A0 (en)
IT (1) IT1148008B (en)
NL (1) NL8101163A (en)
PT (1) PT73156B (en)
SE (1) SE8102455L (en)
ZA (1) ZA811340B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
JPS57142962A (en) * 1981-02-28 1982-09-03 Santen Pharmaceut Co Ltd Cyclodextrin clathrate compound of sulfur-containing compound
US4507316A (en) * 1981-06-01 1985-03-26 Usv Pharmaceutical Corporation Antihypertensive compounds
IN163391B (en) * 1981-11-13 1988-09-17 Exxon Research Engineering Co
US4661515A (en) * 1982-07-21 1987-04-28 Usv Pharmaceutical Corporation Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity
IL69228A0 (en) * 1982-07-21 1983-11-30 Usv Pharma Corp Compounds having diuretic activity and angiotensin converting inhibitory activity,methods of the preparation thereof and pharmaceutical compositions containing the same
US4442038A (en) * 1982-09-17 1984-04-10 Norwich Eaton Pharmaceuticals, Inc. Converting enzyme inhibitors
FR2562068B1 (en) * 1984-03-29 1987-07-17 Roussel Uclaf NOVEL DERIVATIVES OF O-MERCAPTOPROPANAMIDE AND ITS HOMOLOGUES, THEIR PREPARATION METHOD, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS CONTAINING THEM AND THE NEW INTERMEDIATES OBTAINED
EP0384636A1 (en) * 1989-02-21 1990-08-29 FISONS plc Pharmaceutically active compounds
DE4337600A1 (en) * 1993-11-01 1995-05-04 Diagnostikforschung Inst N-alkyl peptide chelating agents, their metal complexes with radionuclides, processes for their preparation and radiopharmaceutical compositions containing these compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides

Also Published As

Publication number Publication date
NL8101163A (en) 1982-01-04
ZA811340B (en) 1982-03-31
SE8102455L (en) 1981-12-10
FR2483916A1 (en) 1981-12-11
PT73156A (en) 1981-07-01
PT73156B (en) 1982-07-16
GR82349B (en) 1984-12-13
DK247181A (en) 1981-12-10
DE3122541A1 (en) 1982-03-25
BE889152A (en) 1981-12-09
ES8206457A1 (en) 1982-08-16
IT8148270A0 (en) 1981-04-13
GB2077719A (en) 1981-12-23
DD159069A5 (en) 1983-02-16
IL62293A0 (en) 1981-05-20
JPS5726656A (en) 1982-02-12
AU6808181A (en) 1981-12-17
ES502153A0 (en) 1982-08-16

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