IT1146135B - Derivati di acidi arilossialchilamminobenzoici dotati di attivita' ipoglicemica e procedimento per la loro preparazione - Google Patents

Info

Publication number

IT1146135B

IT1146135B IT49279/80A IT4927980A IT1146135B IT 1146135 B IT1146135 B IT 1146135B IT 49279/80 A IT49279/80 A IT 49279/80A IT 4927980 A IT4927980 A IT 4927980A IT 1146135 B IT1146135 B IT 1146135B

Authority

IT

Italy

Prior art keywords

opt

lower alkyl

hyperglycaemia

compsn

substd

Prior art date

1979-07-20

Links

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• Global Dossier
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• 206010012601 diabetes mellitus Diseases 0.000 title abstract 3
• 201000001421 hyperglycemia Diseases 0.000 title abstract 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
• -1 1,2,3,4- tetrahydronaphthyl Chemical group 0.000 abstract 3
• 125000000217 alkyl group Chemical group 0.000 abstract 3
• 102000004877 Insulin Human genes 0.000 abstract 2
• 108090001061 Insulin Proteins 0.000 abstract 2
• 125000001589 carboacyl group Chemical group 0.000 abstract 2
• 230000000694 effects Effects 0.000 abstract 2
• 229940125396 insulin Drugs 0.000 abstract 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
• ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 abstract 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
• 241000124008 Mammalia Species 0.000 abstract 1
• 239000002253 acid Substances 0.000 abstract 1
• 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
• 125000003545 alkoxy group Chemical group 0.000 abstract 1
• 125000004848 alkoxyethyl group Chemical group 0.000 abstract 1
• 229960004050 aminobenzoic acid Drugs 0.000 abstract 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
• 239000008280 blood Substances 0.000 abstract 1
• 210000004369 blood Anatomy 0.000 abstract 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
• 125000002091 cationic group Chemical group 0.000 abstract 1
• 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
• 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
• 125000004772 dichloromethyl group Chemical group [H]C(Cl)(Cl)* 0.000 abstract 1
• 125000001153 fluoro group Chemical group F* 0.000 abstract 1
• 239000008103 glucose Substances 0.000 abstract 1
• 125000005843 halogen group Chemical group 0.000 abstract 1
• 125000001624 naphthyl group Chemical group 0.000 abstract 1
• 230000000926 neurological effect Effects 0.000 abstract 1
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
• 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 abstract 1
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
• 230000002792 vascular Effects 0.000 abstract 1