IT1131550B - PROSTACYCLINIC DERIVATIVES - Google Patents

PROSTACYCLINIC DERIVATIVES

Info

Publication number
IT1131550B
IT1131550B IT23142/80A IT2314280A IT1131550B IT 1131550 B IT1131550 B IT 1131550B IT 23142/80 A IT23142/80 A IT 23142/80A IT 2314280 A IT2314280 A IT 2314280A IT 1131550 B IT1131550 B IT 1131550B
Authority
IT
Italy
Prior art keywords
prostacyclinic
derivatives
prostacyclinic derivatives
Prior art date
Application number
IT23142/80A
Other languages
Italian (it)
Other versions
IT8023142A0 (en
Inventor
John Charles Sih
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/054,811 external-priority patent/US4225508A/en
Priority claimed from US06/054,720 external-priority patent/US4225507A/en
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of IT8023142A0 publication Critical patent/IT8023142A0/en
Application granted granted Critical
Publication of IT1131550B publication Critical patent/IT1131550B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT23142/80A 1979-07-05 1980-06-30 PROSTACYCLINIC DERIVATIVES IT1131550B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/054,811 US4225508A (en) 1979-07-05 1979-07-05 19-Hydroxy-PGI2 compounds
US06/054,720 US4225507A (en) 1979-07-05 1979-07-05 19-Hydroxy-19-methyl-PGI2 compounds

Publications (2)

Publication Number Publication Date
IT8023142A0 IT8023142A0 (en) 1980-06-30
IT1131550B true IT1131550B (en) 1986-06-25

Family

ID=26733395

Family Applications (1)

Application Number Title Priority Date Filing Date
IT23142/80A IT1131550B (en) 1979-07-05 1980-06-30 PROSTACYCLINIC DERIVATIVES

Country Status (6)

Country Link
CH (1) CH645369A5 (en)
DE (1) DE3024723A1 (en)
FR (1) FR2460944B1 (en)
GB (1) GB2055811B (en)
IT (1) IT1131550B (en)
NL (1) NL8003829A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2048254B (en) * 1979-04-02 1983-05-25 Upjohn Co 19,20 -didehydro-19-hydroxy and 19-oxo-prostaglandin derivatives
DE3035713A1 (en) * 1980-09-22 1982-04-29 F. Hoffmann-La Roche & Co. AG, 4002 Basel 6,9-Epoxy 15-hydroxy prost-13-enoic and prostanoic acid derivs. - are antisecretories, bronchodilators, blood platelet aggregation inhibitors, antiulcer and antihypertensive cpds.

Also Published As

Publication number Publication date
CH645369A5 (en) 1984-09-28
FR2460944B1 (en) 1987-05-07
NL8003829A (en) 1981-01-07
DE3024723A1 (en) 1981-01-15
GB2055811A (en) 1981-03-11
FR2460944A1 (en) 1981-01-30
IT8023142A0 (en) 1980-06-30
GB2055811B (en) 1983-06-02

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