IT1126725B - Cardiotropic compsns. contg. acylated carnitine derivs. - for treating e.g. myocardial anoxia, ischaemia and arrhythmia - Google Patents
Cardiotropic compsns. contg. acylated carnitine derivs. - for treating e.g. myocardial anoxia, ischaemia and arrhythmiaInfo
- Publication number
- IT1126725B IT1126725B IT4918077A IT4918077A IT1126725B IT 1126725 B IT1126725 B IT 1126725B IT 4918077 A IT4918077 A IT 4918077A IT 4918077 A IT4918077 A IT 4918077A IT 1126725 B IT1126725 B IT 1126725B
- Authority
- IT
- Italy
- Prior art keywords
- cardiotropic
- ischaemia
- carnitine
- treating
- compsns
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compsn. for treating myocardial anoxia, ischaemia, arrhythmic syndromes, fatigue and cardiac decompensation, in humans or animals contains a d,l-carnitine deriv. of formula: (CH2)2N encircled positive -CH2-CH(OR)-CH2-COO encircled negative (I) or its salt. (where R is acetyl, propionyl, butyryl, hydroxybutyryl, hexanoyl, octanoyl, decanoyl, palmitoyl, stearyl or acetoacetyl), together with a pharmaceutical acceptable support. (I) have superior cardiotropic properties to d,l-carnitine (i.e. (I, R is H)) and also give superior protection against the toxicity of adrenalin. (I) are slightly less toxic, LD50 is 630-761 mg/kg mouse i.v. c.f. 610 mg/kg for (I, R is H). The cardiac activity of (I) is independent of coenzyme A.
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT4918077A IT1126725B (en) | 1977-04-29 | 1977-04-29 | Cardiotropic compsns. contg. acylated carnitine derivs. - for treating e.g. myocardial anoxia, ischaemia and arrhythmia |
AU34598/78A AU518617B2 (en) | 1977-04-29 | 1978-03-30 | Therapeutic application of acetyl-d, 1-carnitine |
IE643/78A IE46703B1 (en) | 1977-04-29 | 1978-03-31 | Pharmaceutical compositions containing carnitine derivatives |
ZA00781981A ZA781981B (en) | 1977-04-29 | 1978-04-06 | New therapeutic application of acetyl-d,1-carnitine and other acyl derivatives of d,1-carnitine |
GB13769/78A GB1596491A (en) | 1977-04-29 | 1978-04-07 | Pharmaceutical compositions containing carnitine derivatives |
US05/895,044 US4194006A (en) | 1977-04-29 | 1978-04-10 | Therapeutic application of acetyl-d,l-carnitine and other acyl derivatives of d,l-carnitine |
DE19782817358 DE2817358A1 (en) | 1977-04-29 | 1978-04-20 | NEW THERAPEUTIC APPLICATIONS OF ACYLDER DERIVATIVES OF D, L-CARNITINE |
FR7811863A FR2388556A1 (en) | 1977-04-29 | 1978-04-21 | THERAPEUTIC APPLICATION OF ACETYL-CARNITINE-D, 1 AND OTHER ACYLIC DERIVATIVES OF CARNITINE-D, 1 |
NLAANVRAGE7804567,A NL188078C (en) | 1977-04-29 | 1978-04-27 | PHARMACEUTICAL PREPARATION FOR THE TREATMENT OF HEART ARRHYTMIES AND MYOCARDIAL DISORDERS. |
CH460478A CH636268A5 (en) | 1977-04-29 | 1978-04-27 | PHARMACEUTICAL COMPOSITIONS, CONTAINING DERIVATIVES OF D, 1-CARNITINE ACTIVE IN THE TEREPY OF HEART AFFECTIONS. |
BE187276A BE866568A (en) | 1977-04-29 | 1978-04-28 | THERAPEUTIC COMPOSITIONS CONTAINING D, 1-CARNITINE DERIVATIVES AND THEIR USE |
JP5325878A JPS53136523A (en) | 1977-04-29 | 1978-04-28 | Application of calnitine derivatives to medicine |
KE3223A KE3223A (en) | 1977-04-29 | 1982-07-15 | Pharmaceutical compositions containing carnitine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT4918077A IT1126725B (en) | 1977-04-29 | 1977-04-29 | Cardiotropic compsns. contg. acylated carnitine derivs. - for treating e.g. myocardial anoxia, ischaemia and arrhythmia |
Publications (1)
Publication Number | Publication Date |
---|---|
IT1126725B true IT1126725B (en) | 1986-05-21 |
Family
ID=11269866
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT4918077A IT1126725B (en) | 1977-04-29 | 1977-04-29 | Cardiotropic compsns. contg. acylated carnitine derivs. - for treating e.g. myocardial anoxia, ischaemia and arrhythmia |
Country Status (2)
Country | Link |
---|---|
IT (1) | IT1126725B (en) |
ZA (1) | ZA781981B (en) |
-
1977
- 1977-04-29 IT IT4918077A patent/IT1126725B/en active
-
1978
- 1978-04-06 ZA ZA00781981A patent/ZA781981B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA781981B (en) | 1979-03-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69115148T3 (en) | Atrial irritation device prior to cardiac shock in a dual chamber arrhythmia control system | |
ES384510A1 (en) | Trialkylphosphinegold complexes of 1-beta-d-glucopyranosides | |
FR2411205A1 (en) | PLEUROMUTILINE HETEROSIDIC DERIVATIVES AND THEIR THERAPEUTIC USE | |
BE879978A (en) | SPRAY HEAD | |
FR2411002A1 (en) | COSMETIC PRODUCT | |
IT1126725B (en) | Cardiotropic compsns. contg. acylated carnitine derivs. - for treating e.g. myocardial anoxia, ischaemia and arrhythmia | |
IT1155813B (en) | Cardiotropic compsns. contg. acylated carnitine derivs. - for treating e.g. myocardial anoxia, ischaemia and arrhythmia | |
RU97107153A (en) | DERIVATIVES OF COLHYCIN AND THEIR THERAPEUTIC APPLICATION | |
ATE35372T1 (en) | CHICKEN FLAVOR SPICES AND PROCESS FOR THEIR PRODUCTION. | |
DE69313325D1 (en) | L-Carnitine and Acyl-L-Carnitine esters, with a relaxing effect, selective for the gastrointestinal tract and pharmaceutical compositions containing them | |
ATE157096T1 (en) | SUBSTITUTED TRIAZOLOPYRIDAZINE | |
BR8105437A (en) | PROCESS FOR THE PREPARATION OF AZOLILAQUILA DERIVATIVES, FUNGICIDAL COMPOSITES, PROCESSES FOR COMBATING FUNGI AND FOR THE PREPARATION OF COMPOSITIONS | |
IT1119854B (en) | PHARMACEUTICAL COMPOSITION INCLUDING L-CARNITINE FOR THE TREATMENT OF HEART DYSFUNCTIONS | |
BE817111A (en) | AMIDE DERIVATIVES HAVING HERBICIDAL ACTIVITY AND THEIR PREPARATION PROCESS | |
FR2381781A1 (en) | GUANINE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THESE SUBSTANCES | |
FR2414914A1 (en) | Acylated L-carnitine derivs. - useful for treating myocardial anoxia, ischaemia, arrhythmic syndromes, cardiac insufficiencies, etc. | |
ATE2677T1 (en) | ACYLATED LAIDLOMYCIN DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS. | |
AR245688A1 (en) | Triglyceride quaternary ammonium compounds, their preparation and use | |
GB1036987A (en) | New guanyl hydrazones | |
Field et al. | Biologically oriented organic sulfur chemistry. 9. Carbonyl and thiocarbamoyl disulfides as inhibitory agents for Histoplasma capsulatum | |
SE8600988L (en) | S-PROTECTED MERCAPTOACYL CARNITINES | |
SE8103368L (en) | ALCOXY-ACYL CARNITINES, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
BE872576A (en) | CATHODIC ELECTRODEPOSITION COATING COMPOSITIONS CONTAINING DIELS-ALDER ADDITION PRODUCTS | |
Gendenshteĭn et al. | Pharmacological study of quaternary trimecaine derivatives | |
ES8207128A1 (en) | Carnitinamides of optically active aminoacids |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19960307 |