IT1126725B - Cardiotropic compsns. contg. acylated carnitine derivs. - for treating e.g. myocardial anoxia, ischaemia and arrhythmia - Google Patents

Cardiotropic compsns. contg. acylated carnitine derivs. - for treating e.g. myocardial anoxia, ischaemia and arrhythmia

Info

Publication number
IT1126725B
IT1126725B IT4918077A IT4918077A IT1126725B IT 1126725 B IT1126725 B IT 1126725B IT 4918077 A IT4918077 A IT 4918077A IT 4918077 A IT4918077 A IT 4918077A IT 1126725 B IT1126725 B IT 1126725B
Authority
IT
Italy
Prior art keywords
cardiotropic
ischaemia
carnitine
treating
compsns
Prior art date
Application number
IT4918077A
Other languages
Italian (it)
Original Assignee
Sigam Tau Ind Farmaceutiche Ri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigam Tau Ind Farmaceutiche Ri filed Critical Sigam Tau Ind Farmaceutiche Ri
Priority to IT4918077A priority Critical patent/IT1126725B/en
Priority to AU34598/78A priority patent/AU518617B2/en
Priority to IE643/78A priority patent/IE46703B1/en
Priority to ZA00781981A priority patent/ZA781981B/en
Priority to GB13769/78A priority patent/GB1596491A/en
Priority to US05/895,044 priority patent/US4194006A/en
Priority to DE19782817358 priority patent/DE2817358A1/en
Priority to FR7811863A priority patent/FR2388556A1/en
Priority to NLAANVRAGE7804567,A priority patent/NL188078C/en
Priority to CH460478A priority patent/CH636268A5/en
Priority to BE187276A priority patent/BE866568A/en
Priority to JP5325878A priority patent/JPS53136523A/en
Priority to KE3223A priority patent/KE3223A/en
Application granted granted Critical
Publication of IT1126725B publication Critical patent/IT1126725B/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compsn. for treating myocardial anoxia, ischaemia, arrhythmic syndromes, fatigue and cardiac decompensation, in humans or animals contains a d,l-carnitine deriv. of formula: (CH2)2N encircled positive -CH2-CH(OR)-CH2-COO encircled negative (I) or its salt. (where R is acetyl, propionyl, butyryl, hydroxybutyryl, hexanoyl, octanoyl, decanoyl, palmitoyl, stearyl or acetoacetyl), together with a pharmaceutical acceptable support. (I) have superior cardiotropic properties to d,l-carnitine (i.e. (I, R is H)) and also give superior protection against the toxicity of adrenalin. (I) are slightly less toxic, LD50 is 630-761 mg/kg mouse i.v. c.f. 610 mg/kg for (I, R is H). The cardiac activity of (I) is independent of coenzyme A.
IT4918077A 1977-04-29 1977-04-29 Cardiotropic compsns. contg. acylated carnitine derivs. - for treating e.g. myocardial anoxia, ischaemia and arrhythmia IT1126725B (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT4918077A IT1126725B (en) 1977-04-29 1977-04-29 Cardiotropic compsns. contg. acylated carnitine derivs. - for treating e.g. myocardial anoxia, ischaemia and arrhythmia
AU34598/78A AU518617B2 (en) 1977-04-29 1978-03-30 Therapeutic application of acetyl-d, 1-carnitine
IE643/78A IE46703B1 (en) 1977-04-29 1978-03-31 Pharmaceutical compositions containing carnitine derivatives
ZA00781981A ZA781981B (en) 1977-04-29 1978-04-06 New therapeutic application of acetyl-d,1-carnitine and other acyl derivatives of d,1-carnitine
GB13769/78A GB1596491A (en) 1977-04-29 1978-04-07 Pharmaceutical compositions containing carnitine derivatives
US05/895,044 US4194006A (en) 1977-04-29 1978-04-10 Therapeutic application of acetyl-d,l-carnitine and other acyl derivatives of d,l-carnitine
DE19782817358 DE2817358A1 (en) 1977-04-29 1978-04-20 NEW THERAPEUTIC APPLICATIONS OF ACYLDER DERIVATIVES OF D, L-CARNITINE
FR7811863A FR2388556A1 (en) 1977-04-29 1978-04-21 THERAPEUTIC APPLICATION OF ACETYL-CARNITINE-D, 1 AND OTHER ACYLIC DERIVATIVES OF CARNITINE-D, 1
NLAANVRAGE7804567,A NL188078C (en) 1977-04-29 1978-04-27 PHARMACEUTICAL PREPARATION FOR THE TREATMENT OF HEART ARRHYTMIES AND MYOCARDIAL DISORDERS.
CH460478A CH636268A5 (en) 1977-04-29 1978-04-27 PHARMACEUTICAL COMPOSITIONS, CONTAINING DERIVATIVES OF D, 1-CARNITINE ACTIVE IN THE TEREPY OF HEART AFFECTIONS.
BE187276A BE866568A (en) 1977-04-29 1978-04-28 THERAPEUTIC COMPOSITIONS CONTAINING D, 1-CARNITINE DERIVATIVES AND THEIR USE
JP5325878A JPS53136523A (en) 1977-04-29 1978-04-28 Application of calnitine derivatives to medicine
KE3223A KE3223A (en) 1977-04-29 1982-07-15 Pharmaceutical compositions containing carnitine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT4918077A IT1126725B (en) 1977-04-29 1977-04-29 Cardiotropic compsns. contg. acylated carnitine derivs. - for treating e.g. myocardial anoxia, ischaemia and arrhythmia

Publications (1)

Publication Number Publication Date
IT1126725B true IT1126725B (en) 1986-05-21

Family

ID=11269866

Family Applications (1)

Application Number Title Priority Date Filing Date
IT4918077A IT1126725B (en) 1977-04-29 1977-04-29 Cardiotropic compsns. contg. acylated carnitine derivs. - for treating e.g. myocardial anoxia, ischaemia and arrhythmia

Country Status (2)

Country Link
IT (1) IT1126725B (en)
ZA (1) ZA781981B (en)

Also Published As

Publication number Publication date
ZA781981B (en) 1979-03-28

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