IT1101455B - Bis:tetra:hydro-isoquinolinium quat. salts - useful as neuromuscular blockers for relaxing striated muscle - Google Patents
Bis:tetra:hydro-isoquinolinium quat. salts - useful as neuromuscular blockers for relaxing striated muscleInfo
- Publication number
- IT1101455B IT1101455B IT3022478A IT3022478A IT1101455B IT 1101455 B IT1101455 B IT 1101455B IT 3022478 A IT3022478 A IT 3022478A IT 3022478 A IT3022478 A IT 3022478A IT 1101455 B IT1101455 B IT 1101455B
- Authority
- IT
- Italy
- Prior art keywords
- bis
- salts
- blockers
- striated muscle
- isoquinolinium
- Prior art date
Links
- 239000000842 neuromuscular blocking agent Substances 0.000 title abstract 2
- 210000003699 striated muscle Anatomy 0.000 title abstract 2
- PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 title 1
- 230000002040 relaxant effect Effects 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 230000002999 depolarising effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical class C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 238000002627 tracheal intubation Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Tetrahydroisoquinolinium salts of formula (I) are new. In (I) each of B and C is a gp. of formula (II): where m is 2-4 C is para or meta to B. n is 2-4. Each of R1-7 is H or 1-4C alkoxy. Y is 1-4C alkyl. X- is a pharmaceutically acceptable anion. One at least of R1-4 is alkoxy and >=1 of R5-7 is alkoxy). (I) are neuromuscular blockers which relax striated muscle during surgery or tracheal intubation. They combine the short-term effect of depolarising blockers with the reduced side-effects of non-depolarising blockers. A typical cpd. is the dichloride of bis 3- N-methyl-1-(3,4,5-(MeO)3benzyl -6,7-(MeO)2-1,2,3,4-tetrahy- droisoquinolinium propyl m-phenylene-3,3'-dipropionate.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT3022478A IT1101455B (en) | 1978-11-27 | 1978-11-27 | Bis:tetra:hydro-isoquinolinium quat. salts - useful as neuromuscular blockers for relaxing striated muscle |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT3022478A IT1101455B (en) | 1978-11-27 | 1978-11-27 | Bis:tetra:hydro-isoquinolinium quat. salts - useful as neuromuscular blockers for relaxing striated muscle |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7830224A0 IT7830224A0 (en) | 1978-11-27 |
IT1101455B true IT1101455B (en) | 1985-09-28 |
Family
ID=11229352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT3022478A IT1101455B (en) | 1978-11-27 | 1978-11-27 | Bis:tetra:hydro-isoquinolinium quat. salts - useful as neuromuscular blockers for relaxing striated muscle |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1101455B (en) |
-
1978
- 1978-11-27 IT IT3022478A patent/IT1101455B/en active
Also Published As
Publication number | Publication date |
---|---|
IT7830224A0 (en) | 1978-11-27 |
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