IT1065450B - Novel optically active prostaglandin or its racemate orsalt, useful for providing luteolytic, abortifacient andlabor-inducing activity, controlling reproductive cycle inovulating female mammals and controlling gastric secretion - Google Patents
Novel optically active prostaglandin or its racemate orsalt, useful for providing luteolytic, abortifacient andlabor-inducing activity, controlling reproductive cycle inovulating female mammals and controlling gastric secretionInfo
- Publication number
- IT1065450B IT1065450B IT3045876A IT3045876A IT1065450B IT 1065450 B IT1065450 B IT 1065450B IT 3045876 A IT3045876 A IT 3045876A IT 3045876 A IT3045876 A IT 3045876A IT 1065450 B IT1065450 B IT 1065450B
- Authority
- IT
- Italy
- Prior art keywords
- optically active
- controlling
- racemate
- alkoxy
- hydroxy
- Prior art date
Links
Abstract
An optically active prostaglandin (I) or its racemate or salt is new. An optically active prostaglandin of formula (I) or its racemate or salt is new. A : -CH 2OH, -COOR a, or -CONR bR c; R aH or 1-12C alkyl; R b, R cH or 1-6C alkyl or phenyl; dotted line : single or double bond, when the dotted line is double bond, R 3is H, and R 1and R 2together form oxo group, and when the dotted line is single bond, R 3is hydroxy and one of R 1and R 2is H and the other is hydroxy or acyloxy or R 1and R 2together form oxo group; R 4, R 5H, hydroxy, 1-6C alkoxy or aralkoxy; R 6H or 1-4C alkyl; B' : -(CH 2) n- or -(CH 2) m1-E-(CH 2) m2-; n, m1, m2 : 0, 1, 2 or 3; E : oxygen or sulfur; R : H, 1-6C alkyl, 1-6C alkoxy, 1-6C trihaloalkyl, halo, NRdRe, phenyl optionally substituted by substituent chosen from 1-6C alkoxy and halo, or phenoxy optionally substituted by substituent chosen from 1-6C alkoxy and halo; and R d, R eH, phenyl, benzoyl, 1-6C alkyl or 1-6C aliphatic acyl. Independent claims are included for the following: (1) process for preparation of optically active prostaglandin (I); and (2) cyclopentane-containing compound of formula (i). A' : -CH 2Z, -COOR a, or -CONR bR c; Y' : hydroxy or hydroxy-protecting group bound to the ring through ethereal oxygen atom, preferably 2-tetrahydropyranyloxy; and R" 4, R" 5H, 1-6C alkoxy, aralkoxy, or protecting group, preferably H, 2-tetrahydropyranyloxy or methoxy. [Image] [Image] ACTIVITY : Gynecological; Antiulcer; Gastrointestinal-Gen. No biological data given. MECHANISM OF ACTION : None given.
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT3045876A IT1065450B (en) | 1976-12-16 | 1976-12-16 | Novel optically active prostaglandin or its racemate orsalt, useful for providing luteolytic, abortifacient andlabor-inducing activity, controlling reproductive cycle inovulating female mammals and controlling gastric secretion |
IL51877A IL51877A (en) | 1976-06-01 | 1977-04-14 | -nor-16-benzyl or phenoxy-13,14-dehydro-prostaglandins and process for their preparation |
AU24656/77A AU509127B2 (en) | 1976-06-01 | 1977-04-28 | W-nor-aromatic-13, 14-dehydro-prostaglandins and pharmaceuticals |
GB19657/77A GB1583263A (en) | 1976-06-01 | 1977-05-10 | Nor-aryl-13,14-dehydro-prostaglandins and process for their preparation |
AT333477A AT356302B (en) | 1976-06-01 | 1977-05-10 | METHOD FOR PRODUCING OPTICALLY ACTIVE OR RACEMIC PROSTAGLANDINES AND THEIR SALTS |
DE19772721534 DE2721534A1 (en) | 1976-06-01 | 1977-05-13 | OMEGA-NOR-AROMATIC-13,14-DEHYDRO-PROSTAGLANDINS, THE PROCESS FOR THEIR PRODUCTION AND THE PHARMACEUTICAL AND VETERINAL PRODUCTS CONTAINING THEM |
NZ184187A NZ184187A (en) | 1976-06-01 | 1977-05-24 | W-nor-aromatic-13,14-dehydro-prostaglandins pharmaceutical and veterinary compositions intermediates |
NL7705701A NL7705701A (en) | 1976-06-01 | 1977-05-24 | OMEGA-NOR-AROMATIC-13.14-DEHYDROPROSTAGLAN- TINS AND METHODS OF PREPARATION. |
SU772481552A SU932985A3 (en) | 1976-06-01 | 1977-05-25 | Process for producing optically active or racemic omeganor-aromatic 13,14-dehydroprostaglandines or their salts |
DK233377A DK233377A (en) | 1976-06-01 | 1977-05-26 | PROCEDURE FOR THE PREPARATION OF OMEGA-NORAROMATIC-13,14-DEHYDRO-PROSTAGLANDINS |
JP6314877A JPS52148044A (en) | 1976-06-01 | 1977-05-30 | Omegaanorraromaticc13*144dehydrooprostaglandin* process for manufacture thereof and pharmacological or veterinary compositions containing said prostaglandin |
SE7706310A SE436026B (en) | 1976-06-01 | 1977-05-31 | PROCEDURE FOR THE PREPARATION OF 13,14-DEHYDROPROSTAGLANDINES |
CA279,487A CA1115700A (en) | 1976-06-01 | 1977-05-31 | .omega.-nor-aromatic-13,14-dehydro prostaglandins and process for their preparation |
BE178071A BE855236A (en) | 1976-06-01 | 1977-05-31 | OMEGA-NOR-AROMATIC 13,14-DEHYDRO-PROSTAGLANDIN DERIVATIVES AND PROCESS FOR THEIR PREPARATION |
HU77EA174A HU181424B (en) | 1976-06-01 | 1977-05-31 | Process for preparing omega-nor-aromatic-13,14-dehydro-prostaglandins |
CH665077A CH634831A5 (en) | 1976-06-01 | 1977-05-31 | Process for the preparation of optically active or racemic prostaglandins. |
CS773624A CS192484B2 (en) | 1976-06-01 | 1977-06-01 | Method of preparing optically active or racemic omega-nor-aromatic 13,14-dehydroprostaglandins |
FR7716727A FR2368473A1 (en) | 1976-06-01 | 1977-06-01 | O-NOR-AROMATIQUE-13,14-DEHYDRO-PROSTAGLANDINS, THEIR METHOD OF PREPARATION AND THEIR USE AS CONTRACEPTIVES |
US05/901,999 US4195183A (en) | 1976-06-01 | 1978-05-02 | ω-Nor-aromatic-13,14-dehydro-prostaglandins and process for their preparation |
AT0383179A AT367747B (en) | 1976-06-01 | 1979-05-25 | METHOD FOR PRODUCING OPTICALLY ACTIVE OR RACEMIC PROSTAGLANDINS AND THEIR SALTS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT3045876A IT1065450B (en) | 1976-12-16 | 1976-12-16 | Novel optically active prostaglandin or its racemate orsalt, useful for providing luteolytic, abortifacient andlabor-inducing activity, controlling reproductive cycle inovulating female mammals and controlling gastric secretion |
Publications (1)
Publication Number | Publication Date |
---|---|
IT1065450B true IT1065450B (en) | 1985-02-25 |
Family
ID=11229777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT3045876A IT1065450B (en) | 1976-06-01 | 1976-12-16 | Novel optically active prostaglandin or its racemate orsalt, useful for providing luteolytic, abortifacient andlabor-inducing activity, controlling reproductive cycle inovulating female mammals and controlling gastric secretion |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1065450B (en) |
-
1976
- 1976-12-16 IT IT3045876A patent/IT1065450B/en active
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