IT1065450B - Novel optically active prostaglandin or its racemate orsalt, useful for providing luteolytic, abortifacient andlabor-inducing activity, controlling reproductive cycle inovulating female mammals and controlling gastric secretion - Google Patents

Novel optically active prostaglandin or its racemate orsalt, useful for providing luteolytic, abortifacient andlabor-inducing activity, controlling reproductive cycle inovulating female mammals and controlling gastric secretion

Info

Publication number
IT1065450B
IT1065450B IT3045876A IT3045876A IT1065450B IT 1065450 B IT1065450 B IT 1065450B IT 3045876 A IT3045876 A IT 3045876A IT 3045876 A IT3045876 A IT 3045876A IT 1065450 B IT1065450 B IT 1065450B
Authority
IT
Italy
Prior art keywords
optically active
controlling
racemate
alkoxy
hydroxy
Prior art date
Application number
IT3045876A
Other languages
Italian (it)
Inventor
Carmelo Gandolfi
Franco Faustini
Walter Moretti
Maddalena Maria Usardi
Roberto Ceserani
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Priority to IT3045876A priority Critical patent/IT1065450B/en
Priority to IL51877A priority patent/IL51877A/en
Priority to AU24656/77A priority patent/AU509127B2/en
Priority to GB19657/77A priority patent/GB1583263A/en
Priority to AT333477A priority patent/AT356302B/en
Priority to DE19772721534 priority patent/DE2721534A1/en
Priority to NL7705701A priority patent/NL7705701A/en
Priority to NZ184187A priority patent/NZ184187A/en
Priority to SU772481552A priority patent/SU932985A3/en
Priority to DK233377A priority patent/DK233377A/en
Priority to JP6314877A priority patent/JPS52148044A/en
Priority to HU77EA174A priority patent/HU181424B/en
Priority to SE7706310A priority patent/SE436026B/en
Priority to CA279,487A priority patent/CA1115700A/en
Priority to BE178071A priority patent/BE855236A/en
Priority to CH665077A priority patent/CH634831A5/en
Priority to CS773624A priority patent/CS192484B2/en
Priority to FR7716727A priority patent/FR2368473A1/en
Priority to US05/901,999 priority patent/US4195183A/en
Priority to AT0383179A priority patent/AT367747B/en
Application granted granted Critical
Publication of IT1065450B publication Critical patent/IT1065450B/en

Links

Abstract

An optically active prostaglandin (I) or its racemate or salt is new. An optically active prostaglandin of formula (I) or its racemate or salt is new. A : -CH 2OH, -COOR a, or -CONR bR c; R aH or 1-12C alkyl; R b, R cH or 1-6C alkyl or phenyl; dotted line : single or double bond, when the dotted line is double bond, R 3is H, and R 1and R 2together form oxo group, and when the dotted line is single bond, R 3is hydroxy and one of R 1and R 2is H and the other is hydroxy or acyloxy or R 1and R 2together form oxo group; R 4, R 5H, hydroxy, 1-6C alkoxy or aralkoxy; R 6H or 1-4C alkyl; B' : -(CH 2) n- or -(CH 2) m1-E-(CH 2) m2-; n, m1, m2 : 0, 1, 2 or 3; E : oxygen or sulfur; R : H, 1-6C alkyl, 1-6C alkoxy, 1-6C trihaloalkyl, halo, NRdRe, phenyl optionally substituted by substituent chosen from 1-6C alkoxy and halo, or phenoxy optionally substituted by substituent chosen from 1-6C alkoxy and halo; and R d, R eH, phenyl, benzoyl, 1-6C alkyl or 1-6C aliphatic acyl. Independent claims are included for the following: (1) process for preparation of optically active prostaglandin (I); and (2) cyclopentane-containing compound of formula (i). A' : -CH 2Z, -COOR a, or -CONR bR c; Y' : hydroxy or hydroxy-protecting group bound to the ring through ethereal oxygen atom, preferably 2-tetrahydropyranyloxy; and R" 4, R" 5H, 1-6C alkoxy, aralkoxy, or protecting group, preferably H, 2-tetrahydropyranyloxy or methoxy. [Image] [Image] ACTIVITY : Gynecological; Antiulcer; Gastrointestinal-Gen. No biological data given. MECHANISM OF ACTION : None given.
IT3045876A 1976-06-01 1976-12-16 Novel optically active prostaglandin or its racemate orsalt, useful for providing luteolytic, abortifacient andlabor-inducing activity, controlling reproductive cycle inovulating female mammals and controlling gastric secretion IT1065450B (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
IT3045876A IT1065450B (en) 1976-12-16 1976-12-16 Novel optically active prostaglandin or its racemate orsalt, useful for providing luteolytic, abortifacient andlabor-inducing activity, controlling reproductive cycle inovulating female mammals and controlling gastric secretion
IL51877A IL51877A (en) 1976-06-01 1977-04-14 -nor-16-benzyl or phenoxy-13,14-dehydro-prostaglandins and process for their preparation
AU24656/77A AU509127B2 (en) 1976-06-01 1977-04-28 W-nor-aromatic-13, 14-dehydro-prostaglandins and pharmaceuticals
GB19657/77A GB1583263A (en) 1976-06-01 1977-05-10 Nor-aryl-13,14-dehydro-prostaglandins and process for their preparation
AT333477A AT356302B (en) 1976-06-01 1977-05-10 METHOD FOR PRODUCING OPTICALLY ACTIVE OR RACEMIC PROSTAGLANDINES AND THEIR SALTS
DE19772721534 DE2721534A1 (en) 1976-06-01 1977-05-13 OMEGA-NOR-AROMATIC-13,14-DEHYDRO-PROSTAGLANDINS, THE PROCESS FOR THEIR PRODUCTION AND THE PHARMACEUTICAL AND VETERINAL PRODUCTS CONTAINING THEM
NZ184187A NZ184187A (en) 1976-06-01 1977-05-24 W-nor-aromatic-13,14-dehydro-prostaglandins pharmaceutical and veterinary compositions intermediates
NL7705701A NL7705701A (en) 1976-06-01 1977-05-24 OMEGA-NOR-AROMATIC-13.14-DEHYDROPROSTAGLAN- TINS AND METHODS OF PREPARATION.
SU772481552A SU932985A3 (en) 1976-06-01 1977-05-25 Process for producing optically active or racemic omeganor-aromatic 13,14-dehydroprostaglandines or their salts
DK233377A DK233377A (en) 1976-06-01 1977-05-26 PROCEDURE FOR THE PREPARATION OF OMEGA-NORAROMATIC-13,14-DEHYDRO-PROSTAGLANDINS
JP6314877A JPS52148044A (en) 1976-06-01 1977-05-30 Omegaanorraromaticc13*144dehydrooprostaglandin* process for manufacture thereof and pharmacological or veterinary compositions containing said prostaglandin
SE7706310A SE436026B (en) 1976-06-01 1977-05-31 PROCEDURE FOR THE PREPARATION OF 13,14-DEHYDROPROSTAGLANDINES
CA279,487A CA1115700A (en) 1976-06-01 1977-05-31 .omega.-nor-aromatic-13,14-dehydro prostaglandins and process for their preparation
BE178071A BE855236A (en) 1976-06-01 1977-05-31 OMEGA-NOR-AROMATIC 13,14-DEHYDRO-PROSTAGLANDIN DERIVATIVES AND PROCESS FOR THEIR PREPARATION
HU77EA174A HU181424B (en) 1976-06-01 1977-05-31 Process for preparing omega-nor-aromatic-13,14-dehydro-prostaglandins
CH665077A CH634831A5 (en) 1976-06-01 1977-05-31 Process for the preparation of optically active or racemic prostaglandins.
CS773624A CS192484B2 (en) 1976-06-01 1977-06-01 Method of preparing optically active or racemic omega-nor-aromatic 13,14-dehydroprostaglandins
FR7716727A FR2368473A1 (en) 1976-06-01 1977-06-01 O-NOR-AROMATIQUE-13,14-DEHYDRO-PROSTAGLANDINS, THEIR METHOD OF PREPARATION AND THEIR USE AS CONTRACEPTIVES
US05/901,999 US4195183A (en) 1976-06-01 1978-05-02 ω-Nor-aromatic-13,14-dehydro-prostaglandins and process for their preparation
AT0383179A AT367747B (en) 1976-06-01 1979-05-25 METHOD FOR PRODUCING OPTICALLY ACTIVE OR RACEMIC PROSTAGLANDINS AND THEIR SALTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT3045876A IT1065450B (en) 1976-12-16 1976-12-16 Novel optically active prostaglandin or its racemate orsalt, useful for providing luteolytic, abortifacient andlabor-inducing activity, controlling reproductive cycle inovulating female mammals and controlling gastric secretion

Publications (1)

Publication Number Publication Date
IT1065450B true IT1065450B (en) 1985-02-25

Family

ID=11229777

Family Applications (1)

Application Number Title Priority Date Filing Date
IT3045876A IT1065450B (en) 1976-06-01 1976-12-16 Novel optically active prostaglandin or its racemate orsalt, useful for providing luteolytic, abortifacient andlabor-inducing activity, controlling reproductive cycle inovulating female mammals and controlling gastric secretion

Country Status (1)

Country Link
IT (1) IT1065450B (en)

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