IT1053508B - Labelled polysaccharide compns - for diagnosis of gastro-intestinal disorders - Google Patents

Labelled polysaccharide compns - for diagnosis of gastro-intestinal disorders

Info

Publication number
IT1053508B
IT1053508B IT5144671A IT5144671A IT1053508B IT 1053508 B IT1053508 B IT 1053508B IT 5144671 A IT5144671 A IT 5144671A IT 5144671 A IT5144671 A IT 5144671A IT 1053508 B IT1053508 B IT 1053508B
Authority
IT
Italy
Prior art keywords
polysaccharide
gastro
labelling agent
radionuclide
esp
Prior art date
Application number
IT5144671A
Other languages
Italian (it)
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19712133005 external-priority patent/DE2133005A1/en
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of IT1053508B publication Critical patent/IT1053508B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Compsns contain a polysaccharide capable of being adsorbed differentially on gastro-intestinal mucosa, of mol. wt. >106 and having 1-2 sulphate gps. per mono saccharide unit and an acceptable labelling agent capable of detection. Suitable polysaccharides and Na salts of potato starch amylopectin of mol. wt 6.3 x 107 or 12.5 x 107 contg. 1.6 and 1.8 sulphate gps./glycose residue resp. (e.g. sodium amylosulphate) and the labelling agent is a dye esp. methylene blue or a radionuclide esp. technetium 99.m,I-125 or I-131. Compsns are in form for oral or rectal administration and the labelling agent is detected usually by gastroscope when it is a dye or by isotope scanner or scintillation camera when a radionuclide; gastric ulcers are shown up by the adsorption of polysaccharide the edge of the ulcer.
IT5144671A 1970-07-06 1971-07-06 Labelled polysaccharide compns - for diagnosis of gastro-intestinal disorders IT1053508B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5270770A 1970-07-06 1970-07-06
DE19712133005 DE2133005A1 (en) 1970-07-06 1971-07-02 Diagnostic means to identify abnormal gastrointestinal mucosa

Publications (1)

Publication Number Publication Date
IT1053508B true IT1053508B (en) 1981-10-10

Family

ID=27183532

Family Applications (1)

Application Number Title Priority Date Filing Date
IT5144671A IT1053508B (en) 1970-07-06 1971-07-06 Labelled polysaccharide compns - for diagnosis of gastro-intestinal disorders

Country Status (2)

Country Link
US (1) US3852413A (en)
IT (1) IT1053508B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401646A (en) * 1981-05-08 1983-08-30 University Patents Inc. Method and apparatus for purifying materials radiolabeled with technetium-99m
US4431626A (en) * 1981-05-27 1984-02-14 The Regents Of The University Of California Tc-99m Labeled carrier for imaging
US4851209A (en) * 1982-11-12 1989-07-25 The Regents Of The University Of California Diagnostic procedures using radio labeled sucralfate and derivatives or precursors thereof
US4581221A (en) * 1983-08-29 1986-04-08 Medi Nuclear Corporation, Inc. Ulcer detection
US4670245A (en) * 1984-04-27 1987-06-02 Vasquez Tony E Diagnostic procedures using radiolabeled colloidal bismuth subcitrate and related compounds
US5141739A (en) * 1986-07-03 1992-08-25 Advanced Magnetics, Inc. Delivery of x-ray contrast agents using receptor mediated endocytosis
US5057301A (en) * 1988-04-06 1991-10-15 Neorx Corporation Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents
US5233997A (en) * 1991-04-04 1993-08-10 Baylor College Of Medicine Non-invasive measure of intestinal transit time and uses thereof
WO1996004922A1 (en) * 1994-08-10 1996-02-22 Davis, Joanne, T. Method of using hyaluronic acid for the detection, location and diagnosis of tumors
US5679375A (en) * 1995-06-07 1997-10-21 C.V. Therapeuctics Method of treating ulcers with sulfated polysaccharides
WO1997026018A1 (en) * 1996-01-16 1997-07-24 Zila Pharmaceuticals, Inc. Methods and compositions for in-vivo detection of oral cancers and precancerous conditions
MX9703918A (en) 1997-05-28 1998-11-30 J Marshall M D Barry Procedure to prepare a reactive pharmaceutical product to detect gastrointestinal disorder caused by bacteria in superior gastrointestinal tract.
EP0934986A1 (en) * 1997-12-17 1999-08-11 Roche Diagnostics GmbH Dye-polysaccharide or -cyclosaccharide conjugates and their use as diagnostic agent
US7062312B2 (en) * 2001-01-17 2006-06-13 Pediamed Pharmaceuticals, Inc. Combination and method including a visual marker for determining compliance with a medication regimen
US7008777B2 (en) * 2001-10-15 2006-03-07 Barry J. Marshall System for the detection of urease and method for using same
US6929926B2 (en) 2001-10-15 2005-08-16 Barry J. Marshall Composition for the detection of gastrointestinal disorders
US20030017158A1 (en) * 2002-03-08 2003-01-23 Bernal Samuel D. Method for detecting and killing epithelial cancer cells
US20060264423A1 (en) * 2005-05-20 2006-11-23 Bioenvision, Inc. Methylene Blue Therapy of Viral Disease
WO2007038201A1 (en) * 2005-09-23 2007-04-05 Bioenvision, Inc. Methylene blue therapy of parasitic infections
JP4734074B2 (en) * 2005-09-30 2011-07-27 オリンパスメディカルシステムズ株式会社 Endoscope device
WO2007056439A1 (en) * 2005-11-08 2007-05-18 Collegium Pharmaceutical, Inc. Salts of methylene blue and its derivatives
US20070123520A1 (en) * 2005-11-16 2007-05-31 Bioenvision, Inc. Methylene blue therapy of avian influenza
JP2008069107A (en) * 2006-09-14 2008-03-27 Pentax Corp Agent for fluorescent dyeing of tissue for endoscope
KR100904746B1 (en) * 2007-10-11 2009-06-29 재단법인서울대학교산학협력재단 Method of Injecting Liquid Agents at Acupuncture Points to Arrive Internal Organs and Method of Visualizing Arrival of Liquid Agents
US20100196272A1 (en) 2009-01-30 2010-08-05 Neoprobe Corporation Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran
US20180049423A1 (en) * 2016-08-19 2018-02-22 Scimetrics Limited Corp. Bait Composition

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3637657A (en) * 1968-04-01 1972-01-25 Meito Sangyo Kk Aluminum complex of sulfated polysaccharide and process for the preparation thereof

Also Published As

Publication number Publication date
US3852413A (en) 1974-12-03

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