IT1044809B - Anticoccidial cycloaliphatyloxy or mercapto 4 oxygena - ted 3 quinolinecarboxylic acids - Google Patents
Anticoccidial cycloaliphatyloxy or mercapto 4 oxygena - ted 3 quinolinecarboxylic acidsInfo
- Publication number
- IT1044809B IT1044809B IT3785369A IT3785369A IT1044809B IT 1044809 B IT1044809 B IT 1044809B IT 3785369 A IT3785369 A IT 3785369A IT 3785369 A IT3785369 A IT 3785369A IT 1044809 B IT1044809 B IT 1044809B
- Authority
- IT
- Italy
- Prior art keywords
- anticoccidial
- cycloaliphatyloxy
- mercapto
- cyclopropylmethoxy
- hydroxy
- Prior art date
Links
- 230000001165 anti-coccidial effect Effects 0.000 title abstract 3
- LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical class C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 title abstract 2
- 125000003396 thiol group Chemical class [H]S* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 abstract 1
- YHXPXAKYXANRMM-UHFFFAOYSA-N 5,7-bis(cyclopropylmethoxy)-4-oxo-1H-quinoline-3-carboxylic acid Chemical compound C1(CC1)COC1=C2C(=C(C=NC2=CC(=C1)OCC1CC1)C(=O)O)O YHXPXAKYXANRMM-UHFFFAOYSA-N 0.000 abstract 1
- VZPVFRVCRCMIFW-UHFFFAOYSA-N 6-(cyclopropylmethoxy)-7-decoxy-4-oxo-1H-quinoline-3-carboxylic acid Chemical compound C1(CC1)COC=1C=C2C(=C(C=NC2=CC1OCCCCCCCCCC)C(=O)O)O VZPVFRVCRCMIFW-UHFFFAOYSA-N 0.000 abstract 1
- 208000003495 Coccidiosis Diseases 0.000 abstract 1
- 206010023076 Isosporiasis Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000842 anti-protozoal effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 239000003651 drinking water Substances 0.000 abstract 1
- 235000020188 drinking water Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
- -1 feedstuffs Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Anticoccidial cycloaliphatyloxy or mercapto 4 oxygenated 3 quinolinecarboxylic acids.. are new compds. of the formula: (in which R is cycloaliphatic, A is direct bond or bivalent aliphatic, X = O or S, Ph = 1,2-phenylene R1 = H, lower alkyl, alkenyl, free etherified or esterified OH or carboxyalkyl, aminoglcyl, R-A or aralkyl and R2 = H or lower alkyl), including pharmaceutically acceptable acid addition salts and derivs. thereof. The compds. are prepared by known methods and have anticoccidial activity, being used as compositions, feedstuffs, additives or drinking water containing the active compound alone or in combination with other therapeutic agents for the control of coccidiosis and for growth promotion. The compounds also have anti-bacterial and antiprotozoal activity. Preferred compounds are 5,7-bis-cyclopropylmethoxy-4-hydroxy-3-quinoline carboxylic acid and 6-cyclopropylmethoxy-7-n-decyloxy-4-hydroxy-3-quinoline carboxylic acid and their methyl and ethyl esters and 4-acetate.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73696268A | 1968-06-14 | 1968-06-14 | |
| US77042668A | 1968-10-24 | 1968-10-24 | |
| US80633369A | 1969-03-18 | 1969-03-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IT1044809B true IT1044809B (en) | 1980-04-21 |
Family
ID=27419218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT3785369A IT1044809B (en) | 1968-06-14 | 1969-06-12 | Anticoccidial cycloaliphatyloxy or mercapto 4 oxygena - ted 3 quinolinecarboxylic acids |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1044809B (en) |
-
1969
- 1969-06-12 IT IT3785369A patent/IT1044809B/en active
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