IS7938A - Polymer synthetic neublastin mutant - Google Patents

Polymer synthetic neublastin mutant

Info

Publication number
IS7938A
IS7938A IS7938A IS7938A IS7938A IS 7938 A IS7938 A IS 7938A IS 7938 A IS7938 A IS 7938A IS 7938 A IS7938 A IS 7938A IS 7938 A IS7938 A IS 7938A
Authority
IS
Iceland
Prior art keywords
neublastin
mutant
polymer synthetic
polymer
prolonged
Prior art date
Application number
IS7938A
Other languages
Icelandic (is)
Inventor
Wen-Yee Sah Dinah
R. Pepinsky Blake
Ann Boriack-Sjodin Paula
S. Miller Stephan
Rossomando Anthony
Silvian Laura
Original Assignee
Biogen Idec Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/356,264 external-priority patent/US7442370B2/en
Application filed by Biogen Idec Ma Inc filed Critical Biogen Idec Ma Inc
Publication of IS7938A publication Critical patent/IS7938A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)

Abstract

A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin.
IS7938A 2003-01-31 2005-07-12 Polymer synthetic neublastin mutant IS7938A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/356,264 US7442370B2 (en) 2001-02-01 2003-01-31 Polymer conjugates of mutated neublastin
PCT/US2004/002763 WO2004069176A2 (en) 2001-02-01 2004-02-02 Polymer conjugates of mutated neublastin

Publications (1)

Publication Number Publication Date
IS7938A true IS7938A (en) 2005-07-12

Family

ID=35006489

Family Applications (1)

Application Number Title Priority Date Filing Date
IS7938A IS7938A (en) 2003-01-31 2005-07-12 Polymer synthetic neublastin mutant

Country Status (27)

Country Link
EP (3) EP2301960A3 (en)
JP (3) JP4742025B2 (en)
KR (2) KR101216331B1 (en)
CN (2) CN101166753A (en)
AT (1) ATE478891T1 (en)
AU (1) AU2004209966B9 (en)
BR (1) BRPI0407170A (en)
CA (1) CA2514510C (en)
CY (2) CY1111196T1 (en)
DE (1) DE602004028801D1 (en)
DK (2) DK1594436T3 (en)
EA (1) EA008743B1 (en)
ES (2) ES2450115T3 (en)
GE (3) GEP20135982B (en)
HK (1) HK1085663A1 (en)
IL (2) IL169945A (en)
IS (1) IS7938A (en)
ME (1) MEP43808A (en)
MX (1) MXPA05008168A (en)
NO (1) NO20054025L (en)
NZ (2) NZ541921A (en)
PL (1) PL383683A1 (en)
PT (2) PT1594436E (en)
RS (1) RS52910B (en)
SI (2) SI2246362T1 (en)
UA (2) UA91178C2 (en)
ZA (1) ZA200505707B (en)

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RS52910B (en) * 2003-01-31 2014-02-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
DE602005022082D1 (en) * 2004-08-19 2010-08-12 Biogen Idec Inc REINFORCEMENT OF PROTEINS FROM THE TRANSFORMING GROWTH FACTOR BETA FAMILY
US20140092376A1 (en) * 2012-10-01 2014-04-03 Momentive Performance Materials, Inc. Container and method for in-line analysis of protein compositions
CN110709416A (en) * 2017-01-25 2020-01-17 特沙公司 TGF-beta decoy receptors
US20230074641A1 (en) * 2020-01-27 2023-03-09 Silcotek Corp. Biopharmaceutical manufacturing process and product

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BRPI0407170A (en) 2006-02-21
PL383683A1 (en) 2008-04-14
NO20054025D0 (en) 2005-08-30
EA008743B1 (en) 2007-08-31
GEP20084464B (en) 2008-08-25
EP2301960A2 (en) 2011-03-30
SI2246362T1 (en) 2014-04-30
KR101293805B1 (en) 2013-08-06
KR20120099161A (en) 2012-09-06
RS52910B (en) 2014-02-28
GEP20115137B (en) 2011-01-10
EP1594436A4 (en) 2008-05-28
GEP20135982B (en) 2013-12-10
JP2007525152A (en) 2007-09-06
HK1085663A1 (en) 2006-09-01
CY1111196T1 (en) 2015-06-11
EP2301960A3 (en) 2011-08-03
AU2004209966B2 (en) 2008-04-17
EP1594436B1 (en) 2010-08-25
CA2514510A1 (en) 2004-08-19
EA200501212A2 (en) 2006-08-25
DK1594436T3 (en) 2010-12-13
PT1594436E (en) 2010-11-29
CN102367277A (en) 2012-03-07
CN102367277B (en) 2014-04-09
JP4742025B2 (en) 2011-08-10
ES2450115T3 (en) 2014-03-24
ZA200505707B (en) 2007-01-31
EP1594436A2 (en) 2005-11-16
JP2010184924A (en) 2010-08-26
JP2011078434A (en) 2011-04-21
AU2004209966B9 (en) 2008-06-26
DK2246362T3 (en) 2014-03-10
AU2004209966A1 (en) 2004-08-19
CY1115085T1 (en) 2016-12-14
CN101166753A (en) 2008-04-23
ES2351215T3 (en) 2011-02-01
AU2004209966A2 (en) 2004-08-19
UA105892C2 (en) 2014-07-10
IL169945A (en) 2015-03-31
KR101216331B1 (en) 2012-12-28
SI1594436T1 (en) 2011-01-31
NZ541921A (en) 2010-01-29
EP2246362B1 (en) 2013-12-18
EP2246362A3 (en) 2011-02-23
DE602004028801D1 (en) 2010-10-07
MXPA05008168A (en) 2005-10-05
NZ581460A (en) 2010-02-26
CA2514510C (en) 2013-10-01
RS20050585A (en) 2007-11-15
KR20050099514A (en) 2005-10-13
ATE478891T1 (en) 2010-09-15
IL227752A0 (en) 2013-09-30
NO20054025L (en) 2005-10-31
EP2246362A2 (en) 2010-11-03
PT2246362E (en) 2014-03-10
UA91178C2 (en) 2010-07-12
MEP43808A (en) 2011-02-10
EA200501212A3 (en) 2006-10-27

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