IS4663A - Carbapenem antibiotics, composition, and method of preparing it - Google Patents

Carbapenem antibiotics, composition, and method of preparing it

Info

Publication number
IS4663A
IS4663A IS4663A IS4663A IS4663A IS 4663 A IS4663 A IS 4663A IS 4663 A IS4663 A IS 4663A IS 4663 A IS4663 A IS 4663A IS 4663 A IS4663 A IS 4663A
Authority
IS
Iceland
Prior art keywords
preparing
composition
carbapenem antibiotics
carbapenem
antibiotics
Prior art date
Application number
IS4663A
Other languages
Icelandic (is)
Other versions
IS2353B (en
Inventor
Zimmerman Jeffrey
M. Williams John
A. Bergquist Paul
M. Dimichele Lisa
C. Dubost David
J. Kaufman Michael
R. Sidler Daniel
A. Hunke William
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26309530&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS4663(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9612668.5A external-priority patent/GB9612668D0/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of IS4663A publication Critical patent/IS4663A/en
Publication of IS2353B publication Critical patent/IS2353B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/887—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hetero atom or a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A pharmaceutical composition is disclosed which contains a compound of formula (I) or a pharmaceutically acceptable salt, prodrug or hydrate thereof, in the stabilized form and/or in combination with a carbon dioxide source.
IS4663A 1996-05-28 1998-01-27 Carbapenem antibiotics, composition, and method of preparing it IS2353B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1851896P 1996-05-28 1996-05-28
GBGB9612668.5A GB9612668D0 (en) 1996-06-18 1996-06-18 Carbapenem antibiotic composition and method of preparation
PCT/US1997/008831 WO1997045430A1 (en) 1996-05-28 1997-05-23 Carbapenem antibiotic, composition and method of preparation

Publications (2)

Publication Number Publication Date
IS4663A true IS4663A (en) 1998-01-27
IS2353B IS2353B (en) 2008-04-15

Family

ID=26309530

Family Applications (1)

Application Number Title Priority Date Filing Date
IS4663A IS2353B (en) 1996-05-28 1998-01-27 Carbapenem antibiotics, composition, and method of preparing it

Country Status (34)

Country Link
EP (1) EP0863901B1 (en)
JP (2) JPH11509871A (en)
KR (2) KR100344479B1 (en)
CN (1) CN1067074C (en)
AT (1) ATE252584T1 (en)
AU (1) AU710102B2 (en)
BG (1) BG63821B1 (en)
CA (1) CA2227994C (en)
CO (1) CO4940412A1 (en)
CY (1) CY2437B1 (en)
CZ (1) CZ296381B6 (en)
DE (1) DE69725696T2 (en)
DK (1) DK0863901T3 (en)
DZ (1) DZ2242A1 (en)
EA (1) EA000534B1 (en)
EE (1) EE04678B1 (en)
ES (1) ES2208907T3 (en)
HK (1) HK1016176A1 (en)
HR (1) HRP970281B1 (en)
HU (1) HU229426B1 (en)
ID (1) ID16974A (en)
IL (1) IL123078A (en)
IS (1) IS2353B (en)
MX (1) MX9800808A (en)
NO (1) NO323815B1 (en)
NZ (1) NZ329649A (en)
PL (1) PL188917B1 (en)
PT (1) PT863901E (en)
RS (1) RS49583B (en)
SI (1) SI0863901T1 (en)
SK (1) SK284359B6 (en)
TR (1) TR199800146T1 (en)
TW (1) TW434014B (en)
WO (1) WO1997045430A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0937079A4 (en) * 1996-10-28 2001-01-24 Merck & Co Inc Stabilized carbapenem antibiotic compositions and method of making
US6180783B1 (en) * 1997-06-16 2001-01-30 Merck & Co., Inc. Stabilized carbapenem intermediates and improved process for carbapenem synthesis
JP3245427B2 (en) * 1997-06-16 2002-01-15 メルク エンド カンパニー インコーポレーテッド Stabilized carbapenem intermediates and uses in synthesis
US6504027B1 (en) 1998-03-02 2003-01-07 Merck & Co., Inc. Decarboxylation process for synthesizing carbapenem antibiotics
JP4854899B2 (en) * 1999-10-29 2012-01-18 メルク・シャープ・エンド・ドーム・コーポレイション Formulation of carbapenem antibiotic composition
AR035728A1 (en) 2001-01-16 2004-07-07 Merck & Co Inc PERFECTED PROCESS FOR CARBAPENEM SYNTHESIS
CN101357918B (en) * 2007-06-22 2011-05-18 山东轩竹医药科技有限公司 Penem derivative containing isothioureido sulfhydryl pyrrolidine
CN101367815B (en) * 2007-06-28 2012-07-04 山东轩竹医药科技有限公司 Six-membered ring methanamide substituted sulfhydryl pyrrolidine carbpenem compound
EP2229944A1 (en) 2007-12-12 2010-09-22 Dainippon Sumitomo Pharma Co., Ltd. Preparation composition
CN101550138B (en) * 2008-04-03 2011-05-18 山东轩竹医药科技有限公司 Mercapto azacycloalkyl acidamide alcohol substituted penem derivates
US20110172201A1 (en) * 2008-06-11 2011-07-14 Ranbaxy Laboratories Limited Process for preparing a carbapenem antibiotic composition
CN102365266B (en) 2009-03-31 2013-11-06 三菱综合材料株式会社 Fluorine-containing n-alkyl sulfonyl imide compound, manufacturing method therefor, and method of manufacturing an ionic compound
BRPI1014338B1 (en) 2009-06-25 2019-12-24 Shell Int Research method for injecting water in a formation containing hydrocarbons, and, method for preparing water with high salinity
US8889384B2 (en) 2010-10-07 2014-11-18 Shell Oil Company Process for the production of alcohols from biomass
WO2012061596A1 (en) 2010-11-05 2012-05-10 Shell Oil Company Treating biomass to produce materials useful for biofuels
WO2012088108A1 (en) 2010-12-20 2012-06-28 Shell Oil Company Process for the production of alcohols from biomass
CA2859391C (en) 2011-12-15 2019-12-17 Shell Internationale Research Maatschappij B.V. Method of treating byproducts from ethanol production
CA2873303C (en) 2012-05-17 2021-10-12 Phillip Guy Hamilton Process for producing volatile organic compounds from biomass material
CN103860485A (en) * 2012-12-18 2014-06-18 深圳市海滨制药有限公司 Ertapenem sodium freeze-dried preparation and preparing method thereof
CN106232826A (en) 2014-04-17 2016-12-14 国际壳牌研究有限公司 The method producing fermented product
EP3180320B1 (en) 2014-08-14 2021-01-13 Shell International Research Maatschappij B.V. Process for preparing furfural from biomass

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES525492A0 (en) * 1982-09-10 1985-02-01 Glaxo Group Ltd A PROCEDURE FOR THE PRODUCTION OF A HERMETICALLY CLOSED CONTAINER CONTAINING AT LEAST ONE BETA-LACTAMA ANTIBIOTIC.
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
CA2091309A1 (en) * 1992-03-26 1993-09-27 Frederic H. Jung Antibiotic compounds

Also Published As

Publication number Publication date
RS49583B (en) 2007-04-10
BG102273A (en) 1998-09-30
JP5255983B2 (en) 2013-08-07
PL188917B1 (en) 2005-05-31
IL123078A0 (en) 1998-09-24
SI0863901T1 (en) 2004-04-30
PL324746A1 (en) 1998-06-08
TR199800146T1 (en) 1998-06-22
IS2353B (en) 2008-04-15
HRP970281B1 (en) 2002-04-30
DE69725696T2 (en) 2004-07-29
JPH11509871A (en) 1999-08-31
ID16974A (en) 1997-11-27
JP2009084284A (en) 2009-04-23
EP0863901A1 (en) 1998-09-16
CZ296381B6 (en) 2006-03-15
WO1997045430A1 (en) 1997-12-04
ES2208907T3 (en) 2004-06-16
HU229426B1 (en) 2013-12-30
BG63821B1 (en) 2003-02-28
EA199800180A1 (en) 1998-08-27
PT863901E (en) 2004-02-27
CA2227994C (en) 2002-06-25
EP0863901B1 (en) 2003-10-22
HRP970281A2 (en) 1998-06-30
EE04678B1 (en) 2006-08-15
MX9800808A (en) 1998-04-30
KR19990036052A (en) 1999-05-25
CZ25398A3 (en) 1998-07-15
DZ2242A1 (en) 2002-12-18
CN1198162A (en) 1998-11-04
DE69725696D1 (en) 2003-11-27
CO4940412A1 (en) 2000-07-24
HK1016176A1 (en) 1999-10-29
EE9800022A (en) 1998-08-17
AU710102B2 (en) 1999-09-16
NZ329649A (en) 1998-11-25
IL123078A (en) 2002-03-10
ATE252584T1 (en) 2003-11-15
NO980380D0 (en) 1998-01-28
SK284359B6 (en) 2005-02-04
DK0863901T3 (en) 2004-02-16
TW434014B (en) 2001-05-16
CN1067074C (en) 2001-06-13
YU4198A (en) 1998-12-23
NO323815B1 (en) 2007-07-09
CY2437B1 (en) 2004-11-12
SK10998A3 (en) 1998-08-05
HUP9901567A3 (en) 2000-03-28
EA000534B1 (en) 1999-10-28
KR100403497B1 (en) 2003-10-30
HUP9901567A2 (en) 1999-09-28
NO980380L (en) 1998-03-16
KR100344479B1 (en) 2002-10-31
AU3077597A (en) 1998-01-05
CA2227994A1 (en) 1997-12-04

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