IN2015MU02708AIN2708MU2015AIN2015MU02708AIN 2015MU02708 AIN2015MU02708 AIN 2015MU02708AIN 2708MU2015 AIN2708MU2015 AIN 2708MU2015AIN 2015MU02708 AIN2015MU02708 AIN 2015MU02708A
Authority
IN
India
Prior art keywords
sulphoxide compounds
ricobendazole
albendazole
sulphone
dmc
Prior art date
Application number
Inventor
Ravindra Budha Wagh
Jayashree Milind Nagarkar
Original Assignee
Jayashree Milind Nagarkar
Ravindra Budha Wagh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur
(AREA)
Abstract
An improved Green route has been developed for the synthesis of sulphide to sulphoxide compounds. Using H2O2 as an oxidant in presence of dimethyl carbonate (DMC) as the solvent albendazole is converted to ricobendazole which is important benzimidazole anthelmintic. High yields of corresponding products were obtained by carrying out the reaction at 20-40°C. This synthetic method is environmentally clean and safe, operationally simple with controlling sulphone for the preparation of other sulphoxide compounds.
Method for preparing derivatives of 3-amino-4- (3,4,5,5-tetrasubstituted) -2-oxo-piperidin-1-yl) -4-butyric acid by reaction between a 3,4-diaminobutanoic acid and a 5-hydroxypentanoic acid.