IN2015DN08660A - - Google Patents

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Publication number
IN2015DN08660A
IN2015DN08660A IN8660DEN2015A IN2015DN08660A IN 2015DN08660 A IN2015DN08660 A IN 2015DN08660A IN 8660DEN2015 A IN8660DEN2015 A IN 8660DEN2015A IN 2015DN08660 A IN2015DN08660 A IN 2015DN08660A
Authority
IN
India
Prior art keywords
reductants
antioxidants
stabilizing
beta
synthesis
Prior art date
Application number
Inventor
Muhammad Otabashi
Gauthier Philippart
Samuel Voccia
Ludovic Wouters
Jean-Luc Morelle
Original Assignee
Trasis S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trasis S A filed Critical Trasis S A
Publication of IN2015DN08660A publication Critical patent/IN2015DN08660A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C07B63/04—Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/12—Formation of amino and carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to a method for stabilizing radiosynthetic intermediates used in synthesis of 18F radiolabeled aromatic amino acid derivatives toward decomposition caused by beta and gamma radiations by the use of radical scavengers and/or reductants and/or antioxidants.
IN8660DEN2015 2013-03-22 2014-03-21 IN2015DN08660A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361804371P 2013-03-22 2013-03-22
EP13174707.3A EP2821383B1 (en) 2013-07-02 2013-07-02 Stabilization of radiosynthetic intermediates
PCT/EP2014/055752 WO2014147244A1 (en) 2013-03-22 2014-03-21 Stabilization of radiosynthetic intermediates

Publications (1)

Publication Number Publication Date
IN2015DN08660A true IN2015DN08660A (en) 2015-10-16

Family

ID=48700444

Family Applications (1)

Application Number Title Priority Date Filing Date
IN8660DEN2015 IN2015DN08660A (en) 2013-03-22 2014-03-21

Country Status (9)

Country Link
US (1) US9796641B2 (en)
EP (1) EP2821383B1 (en)
JP (1) JP6435317B2 (en)
KR (1) KR102205673B1 (en)
CN (1) CN105050984B (en)
AU (1) AU2014234260B2 (en)
BE (1) BE1021078B1 (en)
IN (1) IN2015DN08660A (en)
WO (1) WO2014147244A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107311877B (en) * 2017-07-21 2019-03-05 王璐 A kind of positron medicine [18F] FDOPA novel processing step and its intermediate
EP3967674A1 (en) 2020-09-11 2022-03-16 Precirix N.V. Reactions of radioactive compounds facilitated by a solid phase

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3165775B2 (en) * 1994-08-31 2001-05-14 日本鋼管株式会社 Method for producing fluorine radioisotope-labeled L-dopa
DE19949237B4 (en) * 1999-10-13 2004-07-29 Abx Advanced Biochemical Compounds Biomedizinische Forschungsreagenzien Gmbh Precursor compound for radio diagnostics and process for their manufacture
AU2002228725A1 (en) 2000-11-30 2002-06-11 Advanced Research And Technology Institute, Inc. Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
CN1245378C (en) * 2002-01-31 2006-03-15 中国科学院上海原子核研究所 Process for preparing 6-[F]fluoro-L-dopa
CA2783275A1 (en) * 2003-07-24 2005-02-03 Bracco Imaging S.P.A. Stable radiopharmaceutical compositions and methods for their preparation
GB0329716D0 (en) * 2003-12-23 2004-01-28 Amersham Plc Radical trap
DE102007059313A1 (en) * 2007-12-07 2009-06-18 Forschungszentrum Jülich GmbH A process for the preparation of precursors for L-3,4-dihydroxy-6- [18F] fluoro-phenylalanine and 2- [18F] fluoro-L-tyrosine and their α-methylated derivatives, precursors, and to processes for producing L-3 , 4-Dihydroxy-6- [18F] fluoro-phenylalanine and 2- [18F] fluoro-L-tyrosine and their α-methylated derivatives from the precursor
GB0814893D0 (en) * 2008-08-14 2008-09-17 Ge Healthcare Ltd Improved fluoridation of iodonium salts

Also Published As

Publication number Publication date
EP2821383A1 (en) 2015-01-07
US9796641B2 (en) 2017-10-24
JP2016517842A (en) 2016-06-20
AU2014234260B2 (en) 2018-07-26
JP6435317B2 (en) 2018-12-05
CN105050984A (en) 2015-11-11
US20160075615A1 (en) 2016-03-17
KR20150132829A (en) 2015-11-26
CN105050984B (en) 2019-05-21
WO2014147244A1 (en) 2014-09-25
KR102205673B1 (en) 2021-01-22
BE1021078B1 (en) 2015-04-21
AU2014234260A1 (en) 2015-08-20
EP2821383B1 (en) 2017-08-30

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