IN2015DN04090A - - Google Patents
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- Publication number
- IN2015DN04090A IN2015DN04090A IN4090DEN2015A IN2015DN04090A IN 2015DN04090 A IN2015DN04090 A IN 2015DN04090A IN 4090DEN2015 A IN4090DEN2015 A IN 4090DEN2015A IN 2015DN04090 A IN2015DN04090 A IN 2015DN04090A
- Authority
- IN
- India
- Prior art keywords
- phosphorochloridate
- ciu
- nucleosides
- nucleoside
- salts
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 1
- ITVPBBDAZKBMRP-UHFFFAOYSA-N chloro-dioxido-oxo-$l^{5}-phosphane;hydron Chemical compound OP(O)(Cl)=O ITVPBBDAZKBMRP-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 125000003835 nucleoside group Chemical group 0.000 abstract 1
- 150000008298 phosphoramidates Chemical class 0.000 abstract 1
- 125000004437 phosphorous atom Chemical group 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/06—Halogens; Compounds thereof
- B01J27/128—Halogens; Compounds thereof with iron group metals or platinum group metals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S5/00—Semiconductor lasers
- H01S5/30—Structure or shape of the active region; Materials used for the active region
- H01S5/34—Structure or shape of the active region; Materials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers
- H01S5/343—Structure or shape of the active region; Materials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers in AIIIBV compounds, e.g. AlGaAs-laser, InP-based laser
- H01S5/34326—Structure or shape of the active region; Materials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers in AIIIBV compounds, e.g. AlGaAs-laser, InP-based laser with a well layer based on InGa(Al)P, e.g. red laser
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nanotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Materials Engineering (AREA)
- AIDS & HIV (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
Abstract
A process for preparing phosphoramidates of nucleosides where a desired enantiomer having regard to the asymmetric chiral centre of the phosphorus atom P is provided in an enriched amount. The process comprises admixing a nucleoside with a phosphorochloridate in the presence of a catalyst comprising a metal salt selected from the group consisting of salts of Ciu Fe La and Yb.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1220666.0A GB201220666D0 (en) | 2012-11-16 | 2012-11-16 | Process for preparing chemical compounds |
| GB201307314A GB201307314D0 (en) | 2013-04-23 | 2013-04-23 | Process for preparing chemical compounds |
| PCT/GB2013/053018 WO2014076490A1 (en) | 2012-11-16 | 2013-11-15 | Process for preparing nucleoside prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN04090A true IN2015DN04090A (en) | 2015-10-09 |
Family
ID=49622844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN4090DEN2015 IN2015DN04090A (en) | 2012-11-16 | 2013-11-15 |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US10005810B2 (en) |
| EP (3) | EP3235824B1 (en) |
| JP (5) | JP2016506371A (en) |
| KR (1) | KR20150103669A (en) |
| CN (2) | CN104903339A (en) |
| AU (1) | AU2013346515B2 (en) |
| CA (1) | CA2891266C (en) |
| CL (1) | CL2015001307A1 (en) |
| CY (2) | CY1119161T1 (en) |
| DK (2) | DK3150616T3 (en) |
| EA (1) | EA028871B1 (en) |
| ES (3) | ES2725491T3 (en) |
| HR (2) | HRP20170791T1 (en) |
| HU (2) | HUE044605T2 (en) |
| IL (1) | IL238792A (en) |
| IN (1) | IN2015DN04090A (en) |
| LT (2) | LT3235824T (en) |
| MX (1) | MX374779B (en) |
| MY (1) | MY176133A (en) |
| NZ (1) | NZ708177A (en) |
| PH (1) | PH12015501090B1 (en) |
| PL (2) | PL3235824T3 (en) |
| PT (2) | PT3150616T (en) |
| RS (2) | RS56038B1 (en) |
| SG (3) | SG10201510322UA (en) |
| SI (2) | SI3150616T1 (en) |
| SM (2) | SMT201700349T1 (en) |
| WO (1) | WO2014076490A1 (en) |
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|---|---|---|---|---|
| GB0317009D0 (en) | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| ES2725491T3 (en) | 2012-11-16 | 2019-09-24 | Univ College Cardiff Consultants Ltd | Mixture of RP / SP gemcitabine- [phenyl- (benzyloxy-L-alaninyl)] - phosphate |
| US10034893B2 (en) | 2013-02-01 | 2018-07-31 | Enanta Pharmaceuticals, Inc. | 5, 6-D2 uridine nucleoside/tide derivatives |
| KR20160099090A (en) * | 2013-11-27 | 2016-08-19 | 아이데닉스 파마슈티칼스 엘엘씨 | Nucleotides for the treatment of liver cancer |
| CN105153257B (en) * | 2014-06-12 | 2019-03-05 | 正大天晴药业集团股份有限公司 | The preparation method of sofosbuvir |
| RS60968B1 (en) * | 2014-06-25 | 2020-11-30 | NuCana plc | Gemcitabine prodrugs |
| PT3119794T (en) | 2014-06-25 | 2018-01-15 | Nucana Biomed Ltd | Formulation comprising a gemcitabine-prodrug |
| CN105254694B (en) * | 2014-07-14 | 2018-11-27 | 正大天晴药业集团股份有限公司 | Deuterated nucleoside derivates |
| ES2830784T3 (en) | 2014-07-22 | 2021-06-04 | NuCana plc | Process for the preparation of gemcitabine- [phenyl (benzoxy-L-alanyl)] phosphate |
| JP2017522343A (en) * | 2014-07-31 | 2017-08-10 | サンド・アクチエンゲゼルシヤフト | Synthesis of phosphoramidates |
| US9675632B2 (en) | 2014-08-26 | 2017-06-13 | Enanta Pharmaceuticals, Inc. | Nucleoside and nucleotide derivatives |
| CN105461773B (en) * | 2014-09-30 | 2020-12-01 | 江苏豪森药业集团有限公司 | The preparation method of sofosbuvir and its intermediate |
| CN105461774B (en) * | 2014-09-30 | 2020-11-24 | 江苏豪森药业集团有限公司 | The preparation method of sofosbuvir |
| GB201417644D0 (en) * | 2014-10-06 | 2014-11-19 | Nucana Biomed Ltd | Method of separating phosphate diastereoisomers |
| WO2016073756A1 (en) | 2014-11-06 | 2016-05-12 | Enanta Pharmaceuticals, Inc. | Deuterated nucleoside/tide derivatives |
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| CN106397515B (en) * | 2015-07-28 | 2021-05-11 | 广东东阳光药业有限公司 | A kind of improved sofosbuvir preparation method |
| CN106543252A (en) * | 2015-09-16 | 2017-03-29 | 博瑞生物医药（苏州）股份有限公司 | The Preparation Method And Their Intermediate of nucleoside phosphoramidate class prodrug |
| CN106543220A (en) * | 2015-09-16 | 2017-03-29 | 博瑞生物医药（苏州）股份有限公司 | Phosphoramidate compounds and preparation method thereof and crystal |
| CN112156102B (en) | 2015-09-16 | 2023-10-03 | 济南高合医疗科技有限公司 | A crystal form of a single isomer of NUC-1031 and its preparation method |
| CA2994502C (en) | 2015-10-05 | 2023-08-01 | NuCana plc | Combination therapy comprising nuc-1031 and carboplatin for cancer treatment |
| WO2017090264A1 (en) * | 2015-11-27 | 2017-06-01 | 大原薬品工業株式会社 | 5'-position dibenzyl phosphoric acid ester of 5-azacytidine or 2'-deoxy body thereof |
| KR20180101370A (en) * | 2015-12-11 | 2018-09-12 | 뉴카나 피엘씨 | Selective Synthesis of Diastereomers of Phosphate Derivatives and Gemcitabine Prodrug NUC-1031 |
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| GB201609602D0 (en) * | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Chemical compounds |
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| WO2018019188A1 (en) * | 2016-07-23 | 2018-02-01 | 博瑞生物医药（苏州）股份有限公司 | Polymorph of nucleoside phosphoramidate prodrug and preparation method therefor |
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| JP2024525164A (en) | 2021-06-17 | 2024-07-10 | アテア ファーマシューティカルズ， インコーポレイテッド | Advantageous combination anti-HCV therapy |
| CN113549076B (en) * | 2021-07-23 | 2022-12-06 | 中国药科大学 | Polysubstituted purine compound and preparation method and application thereof |
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| ES2725491T3 (en) * | 2012-11-16 | 2019-09-24 | Univ College Cardiff Consultants Ltd | Mixture of RP / SP gemcitabine- [phenyl- (benzyloxy-L-alaninyl)] - phosphate |
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| EP3043803B1 (en) | 2013-09-11 | 2022-04-27 | Emory University | Nucleotide and nucleoside compositions and their uses |
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| KR20160099090A (en) | 2013-11-27 | 2016-08-19 | 아이데닉스 파마슈티칼스 엘엘씨 | Nucleotides for the treatment of liver cancer |
| SG11201604301VA (en) * | 2013-11-27 | 2016-07-28 | Us Health | Piperidine and piperazine derivatives and their use in treating viral infections and cancer |
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| KR20180101370A (en) | 2015-12-11 | 2018-09-12 | 뉴카나 피엘씨 | Selective Synthesis of Diastereomers of Phosphate Derivatives and Gemcitabine Prodrug NUC-1031 |
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| JP2020171815A (en) * | 2020-07-29 | 2020-10-22 | 株式会社ユニバーサルエンターテインメント | program |
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