IN2015DN02296A - - Google Patents
Info
- Publication number
- IN2015DN02296A IN2015DN02296A IN2296DEN2015A IN2015DN02296A IN 2015DN02296 A IN2015DN02296 A IN 2015DN02296A IN 2296DEN2015 A IN2296DEN2015 A IN 2296DEN2015A IN 2015DN02296 A IN2015DN02296 A IN 2015DN02296A
- Authority
- IN
- India
- Prior art keywords
- preparation
- formula
- present
- eslicarbazepine acetate
- provides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
Abstract
The present invention provides a process for the preparation of oxcarbazepine of Formula (1) which is an Active Pharmaceutical Ingredient (API) and a useful intermediate in the preparation of eslicarbazepine acetate of Formula (A). The present invention further provides a process for the preparation of eslicarbazepine acetate.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2296DEN2015 IN2015DN02296A (en) | 2012-09-26 | 2013-09-26 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3003DE2012 | 2012-09-26 | ||
IN2296DEN2015 IN2015DN02296A (en) | 2012-09-26 | 2013-09-26 | |
PCT/IB2013/058892 WO2014049550A1 (en) | 2012-09-26 | 2013-09-26 | Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2015DN02296A true IN2015DN02296A (en) | 2015-08-21 |
Family
ID=49765586
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN2296DEN2015 IN2015DN02296A (en) | 2012-09-26 | 2013-09-26 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20150232426A1 (en) |
EP (1) | EP2900640A1 (en) |
IN (1) | IN2015DN02296A (en) |
WO (1) | WO2014049550A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105130899A (en) * | 2015-08-25 | 2015-12-09 | 安徽省新星药物开发有限责任公司 | Synthetic method for eslicarbazepine acetate |
CN108101844A (en) * | 2018-03-14 | 2018-06-01 | 常州沃腾化工科技有限公司 | The preparation method of 10,11- dihydros -10 oxo -5H- dibenzo [b, f] azepine * -5- formamides |
CN111423307A (en) * | 2020-05-19 | 2020-07-17 | 上海卫希医药科技有限公司 | Reduction method of 2,2,4, 4-tetramethylcyclobutane |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH500196A (en) | 1969-03-10 | 1970-12-15 | Ciba Geigy Ag | Process for the production of new azepine derivatives |
FI75561C (en) | 1979-10-30 | 1988-07-11 | Ciba Geigy Ag | Process for the preparation of 5-carbamoyl-10-oxo-10,11-dihydro-5H-di benz / b, f / azepine and necessary intermediates thereto. |
IT1272897B (en) | 1995-01-13 | 1997-07-01 | I F C Iniziative Finanziaarie | PROCESS FOR THE PRODUCTION OF 10-OXO-10,11-DIIDRO-SH- -DIBENZ (B, F) AZEPIN-5-CARBOXYAMIDE |
PT101732B (en) | 1995-06-30 | 1997-12-31 | Portela & Ca Sa | SUBSTITUTED AZEPINES PROCESS FOR THE PREPARATION OF THE PHARMACEUTICAL COMPOSITIONS CONTAINED THEREOF AND USES OF THE NEW COMPOUNDS IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS EMPLOYED IN DISEASES OF THE NERVOUS SYSTEM |
AT408224B (en) | 1999-03-15 | 2001-09-25 | Dsm Fine Chem Austria Gmbh | METHOD FOR PRODUCING OXCARBAZEPINE |
GB0002740D0 (en) | 2000-02-07 | 2000-03-29 | Novartis Ag | Organic compounds |
GB0111566D0 (en) | 2001-05-11 | 2001-07-04 | Portela & Ca Sa | Method for preparation of (s)-(+)-and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azephine-5-carboxamide |
GB0112812D0 (en) | 2001-05-25 | 2001-07-18 | Portela & Ca Sa | Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom |
CA2407173C (en) | 2001-10-09 | 2009-09-29 | Max India Limited | Process for the preparation of 10-methoxycarbamazepine |
CA2486560A1 (en) | 2002-06-14 | 2003-12-24 | Taro Pharmaceuticals U.S.A., Inc. | Method of preparing a 5h-dibenz[b,f]azepine-5-carboxamide |
GB0223224D0 (en) | 2002-10-07 | 2002-11-13 | Novartis Ag | Organic compounds |
WO2005066133A2 (en) | 2003-10-20 | 2005-07-21 | Amoli Organics Ltd. | NOVEL PROCESS FOR PREPARATION OF 10-OXO-10, 11-DIHYDRO-5H-DIBENZ [b,f]AZEPINE-5-CARBOXAMIDE (OXCARBAZEPINE) VIA INTERMEDIATE, 10-METHOXY-5H-DIBENZ[b,f] AZEPINE-5-CARBONYLCHLORIDE |
ITMI20040452A1 (en) | 2004-03-09 | 2004-06-09 | Clariant Lsm Italia Spa | PROCESS FOR THE PREPARATION OF OXCARBAZEPINA |
US7459553B2 (en) | 2004-03-11 | 2008-12-02 | Glenmark Generics Ltd. | Process for the preparation of carboxamide compounds |
WO2005096709A2 (en) | 2004-03-11 | 2005-10-20 | Sun Pharmaceutical Industries Limited | A process for the preparation of 10,11-dihydro-10-oxo-5h-dibenz[b,f]azepine-5-carboxamide |
EP1600443A1 (en) | 2004-05-26 | 2005-11-30 | Alberto Milanese | Process for the preparation of oxcarbazepine |
CA2471666C (en) | 2004-06-18 | 2009-10-13 | Apotex Pharmachem Inc. | An improved process for the preparation of oxcarbazepine and related intermediates |
GB2416167A (en) | 2004-07-13 | 2006-01-18 | Portela & Ca Sa | Chiral inversion and esterification of (S)- and (R)-10-hydroxy-dibenzazepine carboxamides |
ITMI20042291A1 (en) | 2004-11-26 | 2005-02-26 | Farchema S R L | PROCEDURE FOR THE PREPARATION OF -S-PIU-10,11-DIIDRO-10-HYDROXY-5H-DIBENZ-B, F-AZEPIN-5-CARBOSSIAMMIDE |
GB2422149A (en) | 2005-01-14 | 2006-07-19 | Portela & Ca Sa | Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide |
GB0515690D0 (en) | 2005-07-29 | 2005-09-07 | Portela & Ca Sa | Asymmetric catalytic reduction |
GB2437078A (en) | 2006-04-11 | 2007-10-17 | Portela & Ca Sa | 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives |
WO2007141798A1 (en) | 2006-06-07 | 2007-12-13 | Jubilant Organosys Limited | Process for producing oxcarbazepine via an 11-alkoxy-10-halo-dihydroiminostilbene intermediate |
WO2008012837A1 (en) | 2006-07-24 | 2008-01-31 | Jubilant Organosys Limited | Process for producing 10-oxo-l10, 11-dihydr0-5h-dibenz [b, f] azepine-5-carboxamide starting from 5-cyanoiminostilbene |
WO2009139001A2 (en) | 2008-05-08 | 2009-11-19 | Matrix Laboratories Ltd | An improved process for the preparation of oxcarbazepine |
CN100591672C (en) | 2008-07-04 | 2010-02-24 | 浙江工业大学 | Chemical synthesis method for oxcarbazepine |
WO2010113179A2 (en) | 2009-04-02 | 2010-10-07 | Glenmark Generics Limited | A process for the purification of eslicarbazepine acetate |
WO2011091131A2 (en) | 2010-01-23 | 2011-07-28 | Dr. Reddy's Laboratories Ltd. | Eslicarbazepine acetate and its polymorphs |
EP2383261B1 (en) | 2010-04-23 | 2013-09-04 | Euticals GmbH | Process for the asymmetric hydrogenation of ketones |
-
2013
- 2013-09-26 WO PCT/IB2013/058892 patent/WO2014049550A1/en active Application Filing
- 2013-09-26 US US14/428,418 patent/US20150232426A1/en not_active Abandoned
- 2013-09-26 IN IN2296DEN2015 patent/IN2015DN02296A/en unknown
- 2013-09-26 EP EP13805534.8A patent/EP2900640A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2014049550A1 (en) | 2014-04-03 |
US20150232426A1 (en) | 2015-08-20 |
EP2900640A1 (en) | 2015-08-05 |
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