IN2015DN01147A - - Google Patents
Info
- Publication number
- IN2015DN01147A IN2015DN01147A IN1147DEN2015A IN2015DN01147A IN 2015DN01147 A IN2015DN01147 A IN 2015DN01147A IN 1147DEN2015 A IN1147DEN2015 A IN 1147DEN2015A IN 2015DN01147 A IN2015DN01147 A IN 2015DN01147A
- Authority
- IN
- India
- Prior art keywords
- composition
- variable domain
- single variable
- treatment
- stabilising
- Prior art date
Links
- 239000000203 mixture Substances 0.000 abstract 3
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010017943 Gastrointestinal conditions Diseases 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 229960000772 camostat Drugs 0.000 abstract 1
- XASIMHXSUQUHLV-UHFFFAOYSA-N camostat Chemical compound C1=CC(CC(=O)OCC(=O)N(C)C)=CC=C1OC(=O)C1=CC=C(N=C(N)N)C=C1 XASIMHXSUQUHLV-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003019 stabilising effect Effects 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/204—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Nutrition Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The present disclosure provides a means of stabilising a single variable domain in particular in protease rich environments such as the stomach and intestine. A composition in particular a pharmaceutical composition comprising a single variable domain and camostat mesylate is provided together with uses of said composition as a medicament and in methods of treatment. Compositions of the disclosure are particularly useful in the topical treatment of gastrointestinal conditions such as Crohn's Disease or ulcerative colitis or for direct activity in the gut mucosal immune system.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261691443P | 2012-08-21 | 2012-08-21 | |
PCT/IB2013/001814 WO2014030049A2 (en) | 2012-08-21 | 2013-08-21 | Compositions comprising a single variable domain and camostat mesylate (cm) |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2015DN01147A true IN2015DN01147A (en) | 2015-06-26 |
Family
ID=49510445
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN1147DEN2015 IN2015DN01147A (en) | 2012-08-21 | 2015-02-12 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20150306058A1 (en) |
EP (1) | EP2887960A2 (en) |
JP (1) | JP2015527357A (en) |
KR (1) | KR20150043342A (en) |
CN (1) | CN104884089A (en) |
AU (1) | AU2013304627A1 (en) |
BR (1) | BR112015003851A2 (en) |
CA (1) | CA2882684A1 (en) |
IN (1) | IN2015DN01147A (en) |
RU (1) | RU2015110027A (en) |
WO (1) | WO2014030049A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3663B1 (en) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | Anti-lag3 antibodies and antigen-binding fragments |
CN113016720B (en) * | 2014-11-24 | 2023-02-21 | 瑞泽恩制药公司 | Non-human animals expressing humanized CD3 complexes |
CN114920847A (en) * | 2015-05-13 | 2022-08-19 | 埃博灵克斯股份有限公司 | T cell recruitment polypeptides based on CD3 responsiveness |
KR102194188B1 (en) | 2015-11-18 | 2020-12-24 | 머크 샤프 앤드 돔 코포레이션 | PD1 and/or LAG3 binder |
JP7000322B2 (en) | 2015-12-16 | 2022-02-04 | メルク・シャープ・アンド・ドーム・コーポレーション | Anti-LAG3 antibody and antigen-binding fragment |
SG11201807402PA (en) * | 2016-03-31 | 2018-09-27 | Vhsquared Ltd | Compositions |
MX2021015761A (en) | 2019-06-21 | 2022-04-18 | Sorriso Pharmaceuticals Inc | Polypeptides. |
CN114514243A (en) | 2019-06-21 | 2022-05-17 | 索瑞索制药公司 | Polypeptides |
WO2021188815A1 (en) * | 2020-03-18 | 2021-09-23 | Memorial Sloan Kettering Cancer Center | Inhalational therapy for covid-19 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
-
2013
- 2013-08-21 BR BR112015003851A patent/BR112015003851A2/en not_active IP Right Cessation
- 2013-08-21 US US14/422,706 patent/US20150306058A1/en not_active Abandoned
- 2013-08-21 EP EP13783662.3A patent/EP2887960A2/en not_active Withdrawn
- 2013-08-21 RU RU2015110027A patent/RU2015110027A/en not_active Application Discontinuation
- 2013-08-21 AU AU2013304627A patent/AU2013304627A1/en not_active Abandoned
- 2013-08-21 KR KR20157004323A patent/KR20150043342A/en not_active Application Discontinuation
- 2013-08-21 WO PCT/IB2013/001814 patent/WO2014030049A2/en active Application Filing
- 2013-08-21 CN CN201380044476.9A patent/CN104884089A/en active Pending
- 2013-08-21 JP JP2015527976A patent/JP2015527357A/en active Pending
- 2013-08-21 CA CA2882684A patent/CA2882684A1/en not_active Abandoned
-
2015
- 2015-02-12 IN IN1147DEN2015 patent/IN2015DN01147A/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2015110027A (en) | 2016-10-10 |
KR20150043342A (en) | 2015-04-22 |
EP2887960A2 (en) | 2015-07-01 |
CN104884089A (en) | 2015-09-02 |
WO2014030049A3 (en) | 2014-04-17 |
US20150306058A1 (en) | 2015-10-29 |
AU2013304627A1 (en) | 2015-02-26 |
BR112015003851A2 (en) | 2017-08-08 |
WO2014030049A2 (en) | 2014-02-27 |
CA2882684A1 (en) | 2014-02-27 |
JP2015527357A (en) | 2015-09-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IN2015DN01147A (en) | ||
BR112014032699A2 (en) | Pediatric metabolic syndrome treatment methods | |
PL2753343T3 (en) | Composition comprising n-acetylcysteine and probiotic bacteria capable of restoring the stomach's own barrier effect which is lost during treatment of gastric hyperacidity with proton pump inhibitors | |
MX2020010535A (en) | Methods of treating cancer. | |
BR112013026690A2 (en) | A composition comprising probiotic bacteria capable of restoring the stomach barrier effect that is lost during the pharmacological treatment of gastric hyperacidity. | |
IN2012DN06720A (en) | ||
EP2528934A4 (en) | Aromatic-cationic peptides and uses of same | |
SI2935303T1 (en) | 4'-fluoro-nucleosides, 4'-fluoro-nucleotides and analogs thereof for the treatment of hcv | |
MX2021000715A (en) | Compositions and methods for treating metabolic disorders. | |
MX2012007806A (en) | Pharmaceutical compositions for oral administration of insulin peptides. | |
MX2013004061A (en) | Cyclosporin analogs. | |
MX2016003490A (en) | Co rti statin analogues for the treatment of inflammatory and/or immune diseases. | |
SG10201502583VA (en) | Immunogenic proteins and compositions for the treatment and prevention of streptococcus agalactiae | |
MX364220B (en) | Methods of treating fibrosis. | |
MY168778A (en) | Oligonucleotide chelate complex-polypeptide compositions and methods | |
MX2015000485A (en) | Treatment of multiple sclerosis with combination of laquinimod and fampridine. | |
IN2014DN07326A (en) | ||
IL251687B (en) | Pharmaceutical composition for use in the treatment or prevention of vitamin and mineral deficiencies in patients which have been subjected to gastric bypass-surgery | |
WO2014030052A3 (en) | Compositions comprising an antibody and camostat mesylate (cm) | |
MA41220A (en) | DIETARY SUPPLEMENT CONSISTING OF A BLEND OF MAGNESIUM OXIDE AND MAGNESIUM CARBONATE | |
EA201590732A1 (en) | DISPENSABLE TABLET | |
BR112014015193A2 (en) | glycoprotein enriched composition as a food and / or feed additive and / or as a therapeutic agent | |
AU2016903444A0 (en) | This invention is a lightweight, closely-fitted yet non-restrictive shirt containing three long pockets; two of which run along the full length of both sides of the shirt and one that runs down the full length of the back of the shirt along the length of the spine. Into these pockets, specially shaped long pads of varying dimensions can be inserted which act as spinal support and as non-invasive correctional treatment to be used in conjunction with such non-invasive treatment methods when the shirt is worn. | |
MX2017011838A (en) | Compositions and methods for treating hepatocellular carcinoma. | |
TR201204288A2 (en) | Tablet formulation containing levodopa, carbidopa, entacapone. |