IN2015DN01010A - - Google Patents
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- Publication number
- IN2015DN01010A IN2015DN01010A IN1010DEN2015A IN2015DN01010A IN 2015DN01010 A IN2015DN01010 A IN 2015DN01010A IN 1010DEN2015 A IN1010DEN2015 A IN 1010DEN2015A IN 2015DN01010 A IN2015DN01010 A IN 2015DN01010A
- Authority
- IN
- India
- Prior art keywords
- separating
- targets
- extraction chromatography
- leaching
- isotops
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 2
- 238000002386 leaching Methods 0.000 abstract 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B60/00—Obtaining metals of atomic number 87 or higher, i.e. radioactive metals
- C22B60/02—Obtaining thorium, uranium, or other actinides
- C22B60/0295—Obtaining thorium, uranium, or other actinides obtaining other actinides except plutonium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
- B01D15/206—Packing or coating
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B7/00—Working up raw materials other than ores, e.g. scrap, to produce non-ferrous metals and compounds thereof; Methods of a general interest or applied to the winning of more than two metals
- C22B7/005—Separation by a physical processing technique only, e.g. by mechanical breaking
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B7/00—Working up raw materials other than ores, e.g. scrap, to produce non-ferrous metals and compounds thereof; Methods of a general interest or applied to the winning of more than two metals
- C22B7/006—Wet processes
- C22B7/007—Wet processes by acid leaching
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B7/00—Working up raw materials other than ores, e.g. scrap, to produce non-ferrous metals and compounds thereof; Methods of a general interest or applied to the winning of more than two metals
- C22B7/009—General processes for recovering metals or metallic compounds from spent catalysts
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
- G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
- G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0089—Actinium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P10/00—Technologies related to metal processing
- Y02P10/20—Recycling
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Geology (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Environmental & Geological Engineering (AREA)
- Health & Medical Sciences (AREA)
- High Energy & Nuclear Physics (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Extraction Or Liquid Replacement (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
The present invention describes a method for purification of 225Ac from irradiated 226Ra-targets provided on a support, comprising a leaching treatment of the 226Ra-targets for leaching essentially the entirety of 225Ac and 226Ra with nitric or hydrochloric acid, followed by a first extraction chromatography for separating 225Ac from 226Ra and other Ra-isotops and a second extraction chromatography for separating 225Ac from 210Po and 210Pb. The finally purified 225Ac can be used to prepare compositions useful for pharmaceutical purposes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006008023A DE102006008023B4 (en) | 2006-02-21 | 2006-02-21 | Method of cleaning 225Ac from irradiated 226Ra targets |
| PCT/EP2007/001424 WO2007096119A2 (en) | 2006-02-21 | 2007-02-19 | Method for purification of 225ac from irradiated 226ra-targets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN01010A true IN2015DN01010A (en) | 2015-07-10 |
Family
ID=38319730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1010DEN2015 IN2015DN01010A (en) | 2006-02-21 | 2007-02-19 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20090191122A1 (en) |
| EP (1) | EP1987522B1 (en) |
| JP (1) | JP5145545B2 (en) |
| CN (1) | CN101390171B (en) |
| AT (1) | ATE474319T1 (en) |
| CA (1) | CA2640768C (en) |
| DE (2) | DE102006008023B4 (en) |
| ES (1) | ES2350150T3 (en) |
| IN (1) | IN2015DN01010A (en) |
| RU (1) | RU2432632C2 (en) |
| WO (1) | WO2007096119A2 (en) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004022200B4 (en) | 2004-05-05 | 2006-07-20 | Actinium Pharmaceuticals, Inc. | Radium target and process for its preparation |
| DE102006008023B4 (en) | 2006-02-21 | 2008-05-29 | Actinium Pharmaceuticals, Inc. | Method of cleaning 225Ac from irradiated 226Ra targets |
| EP2796575B8 (en) | 2006-09-08 | 2020-04-01 | Actinium Pharmaceuticals, Inc. | Method for the purification of radium from different sources |
| US9202602B2 (en) * | 2010-02-10 | 2015-12-01 | Uchicago Argonne, Llc | Production of isotopes using high power proton beams |
| GB201007354D0 (en) * | 2010-04-30 | 2010-06-16 | Algeta Asa | Method |
| GB201314718D0 (en) | 2013-08-16 | 2013-10-02 | Algeta As | Quantification method |
| WO2015138910A1 (en) * | 2014-03-13 | 2015-09-17 | Bracco Diagnostics Inc. | Real time nuclear isotope detection |
| CZ305667B6 (en) * | 2014-08-21 | 2016-01-27 | České Vysoké Učení Technické V Praze, Fakulta Jaderná A Fyzikálně Inženýrská, Katedra Jaderné Chemie | Method of chromatographic separation of radionuclide mixture, chromatographic paper, process for its preparation and kit for radionuclide mixture separation |
| JP6464475B2 (en) * | 2015-03-02 | 2019-02-06 | 清水建設株式会社 | Method for analyzing radioactive strontium |
| RU2741629C2 (en) | 2016-09-20 | 2021-01-28 | Бракко Дайэгностикс Инк. | Systems and methods of production, infusion input and control of radioactive isotope delivery |
| EP3773996A4 (en) | 2018-03-26 | 2022-03-30 | Triumf | SYSTEMS, APPARATUS AND METHODS FOR SEPARATE ACTINIUM, RADIUM AND THORIUM |
| CN112106148B (en) | 2018-03-28 | 2024-10-29 | 布拉科诊断公司 | Early detection of radioisotope generator life |
| CN112074917B (en) | 2018-03-28 | 2024-10-29 | 布拉科诊断公司 | Systems and techniques for calibrating radioisotope delivery systems using gamma detectors |
| EP3682959A1 (en) * | 2019-01-16 | 2020-07-22 | Sck Cen | Purification of actinium |
| US20220199276A1 (en) * | 2019-04-08 | 2022-06-23 | The Regents Of The University Of California | Systems and methods for producing actinium-225 |
| KR102533289B1 (en) | 2019-06-19 | 2023-05-17 | 니혼 메디피직스 가부시키가이샤 | 226Ra target manufacturing method, 225Ac manufacturing method, and electrodeposition solution for manufacturing 226Ra target |
| JP7696832B2 (en) * | 2019-06-25 | 2025-06-23 | ザ ヨーロピアン ユニオン、リプレゼンテッド バイ ザ ヨーロピアン コミッション | Method for producing 225-actinium from 226-radium |
| JP7312621B2 (en) | 2019-06-26 | 2023-07-21 | 株式会社日立製作所 | Radionuclide production method and radionuclide production system |
| RU2736600C1 (en) * | 2019-07-02 | 2020-11-19 | Федеральное государственное автономное образовательное учреждение высшего образования "Уральский федеральный университет имени первого Президента России Б.Н. Ельцина" | Method of producing actinium-228 radionuclide generator |
| AU2020298961B2 (en) | 2019-07-02 | 2026-02-19 | Nihon Medi-Physics Co., Ltd. | METHOD FOR PURIFYING 226Ra-CONTAINING SOLUTION, METHOD FOR PRODUCING 226Ra TARGET, AND METHOD FOR PRODUCING 225Ac |
| KR102211812B1 (en) * | 2019-07-23 | 2021-02-04 | 한국원자력의학원 | The method of producing actinium by liquified radium |
| KR102233112B1 (en) * | 2019-07-25 | 2021-03-29 | 한국원자력의학원 | The apparatus of producing nuclide using fluid target |
| KR102264831B1 (en) * | 2019-07-29 | 2021-06-15 | 한국원자력의학원 | Powder type target with improved beam irradiation efficiency, apparatus for producing nuclides comprising the same, and production method |
| EP3800648A1 (en) * | 2019-10-04 | 2021-04-07 | Sck Cen | Methods and systems for the production of isotopes |
| EP3828899B1 (en) * | 2019-11-29 | 2022-01-05 | Ion Beam Applications | A method for producing ac-225 from ra-226 |
| CN115104159A (en) | 2020-02-21 | 2022-09-23 | 布拉科诊断公司 | Early breakthrough detection for radioisotope generators |
| CN111724926B (en) * | 2020-06-09 | 2022-08-09 | 西安迈斯拓扑科技有限公司 | Production of medical isotope 225 Ac process and apparatus |
| KR20230039646A (en) | 2020-07-17 | 2023-03-21 | 니혼 메디피직스 가부시키가이샤 | Method for preparing 225Ac solution |
| US10867716B1 (en) * | 2020-09-11 | 2020-12-15 | King Abdulaziz University | Systems and methods for producing Actinium-225 |
| WO2022149535A1 (en) * | 2021-01-08 | 2022-07-14 | 日本メジフィジックス株式会社 | Ra-226 RECOVERY METHOD, Ra-226 SOLUTION PRODUCTION METHOD, AND Ac-225 SOLUTION PRODUCTION METHOD |
| JP7154465B1 (en) * | 2021-01-08 | 2022-10-17 | 日本メジフィジックス株式会社 | Method for producing Ac-225 solution and method for producing medicament using Ac-225 solution |
| KR20230173150A (en) | 2021-04-20 | 2023-12-26 | 테라파워, 엘엘씨 | Titania-based generator for generating AC-225 |
| US11541134B1 (en) | 2021-08-02 | 2023-01-03 | Rayzebio, Inc. | Stabilized compositions of radionuclides and uses thereof |
| US12398445B2 (en) * | 2022-01-20 | 2025-08-26 | Purdue Research Foundation | Background Rn-rejected actinide in air spectroscopy |
| CN115869658B (en) * | 2022-12-29 | 2025-01-28 | 中国核动力研究设计院 | Separation system for preparing Ra-223, separation method, application and preparation method thereof |
| CN116741428A (en) * | 2023-07-03 | 2023-09-12 | 西安迈斯拓扑科技有限公司 | Method for simultaneous preparation of 225Ac and 212Pb based on accelerator irradiation of 226Ra |
| WO2026015045A1 (en) * | 2024-07-12 | 2026-01-15 | Акционерное Общество "Государственный Научный Центр - Научно-Исследовательский Институт Атомных Реакторов" | Method for mutual separation of radium, actinium and thorium |
| WO2026063503A1 (en) * | 2024-09-20 | 2026-03-26 | 日本メジフィジックス株式会社 | Method for producing ac-225 solution and method for producing ac-225 labeled complex using solution |
| CN120183769B (en) * | 2025-03-18 | 2026-03-24 | 西安迈斯拓扑科技有限公司 | A method for the separation and purification of lead-212 and actinium-225 prepared by photonuclear reaction. |
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| US2442617A (en) * | 1942-10-31 | 1948-06-01 | Canadian Radium & Uranium Corp | Carrier for radioactive material and improved method of making the same |
| US2632763A (en) * | 1948-05-25 | 1953-03-24 | French T Hagemann | Separation process for actinium |
| US2554649A (en) * | 1948-12-13 | 1951-05-29 | Edward R Tompkins | Separation of radium from barium |
| US3351049A (en) * | 1965-04-12 | 1967-11-07 | Hazleton Nuclear Science Corp | Therapeutic metal seed containing within a radioactive isotope disposed on a carrier and method of manufacture |
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| EP1763372B1 (en) * | 2004-06-25 | 2016-11-30 | The European Union, represented by the European Commission | Radionuclides for medical use |
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| US7378372B2 (en) * | 2005-10-11 | 2008-05-27 | Layne Christensen Company | Filter and sorbent for removal of contaminants from a fluid |
| DE102006008023B4 (en) | 2006-02-21 | 2008-05-29 | Actinium Pharmaceuticals, Inc. | Method of cleaning 225Ac from irradiated 226Ra targets |
| EP2796575B8 (en) | 2006-09-08 | 2020-04-01 | Actinium Pharmaceuticals, Inc. | Method for the purification of radium from different sources |
-
2006
- 2006-02-21 DE DE102006008023A patent/DE102006008023B4/en not_active Expired - Lifetime
-
2007
- 2007-02-19 RU RU2008129795/07A patent/RU2432632C2/en active
- 2007-02-19 IN IN1010DEN2015 patent/IN2015DN01010A/en unknown
- 2007-02-19 DE DE602007007733T patent/DE602007007733D1/en active Active
- 2007-02-19 CN CN2007800060725A patent/CN101390171B/en active Active
- 2007-02-19 CA CA2640768A patent/CA2640768C/en active Active
- 2007-02-19 EP EP07711580A patent/EP1987522B1/en active Active
- 2007-02-19 JP JP2008554697A patent/JP5145545B2/en active Active
- 2007-02-19 WO PCT/EP2007/001424 patent/WO2007096119A2/en not_active Ceased
- 2007-02-19 ES ES07711580T patent/ES2350150T3/en active Active
- 2007-02-19 US US12/280,079 patent/US20090191122A1/en not_active Abandoned
- 2007-02-19 AT AT07711580T patent/ATE474319T1/en not_active IP Right Cessation
-
2013
- 2013-05-13 US US13/893,056 patent/US20130266475A1/en not_active Abandoned
-
2014
- 2014-03-31 US US14/231,354 patent/US9534277B1/en active Active
-
2016
- 2016-11-22 US US15/359,053 patent/US9790573B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DE102006008023B4 (en) | 2008-05-29 |
| CN101390171A (en) | 2009-03-18 |
| JP5145545B2 (en) | 2013-02-20 |
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| US20130266475A1 (en) | 2013-10-10 |
| EP1987522B1 (en) | 2010-07-14 |
| EP1987522A2 (en) | 2008-11-05 |
| CN101390171B (en) | 2013-02-13 |
| JP2009527731A (en) | 2009-07-30 |
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